Results 81 to 90 of about 30,453 (235)

Impact of G‐CSF on Donor TCR Clonal Diversity and T Cell Function During Donor HSC Mobilisation

Cell Proliferation, EarlyView.
In this study, we found that G‐CSF mobilisation caused a reduction in TCR clonal diversity and down‐regulation of T‐cell function in donors. This may be one of the reasons for the low incidence of GVHD mediated by G‐CSF after allo‐HSCT. Source: Created in BioRender. Li https://BioRender.com/otownki.
Xinye Li, Zhixi Chen, Jie Chen, Xingwei Zhang, Jiamian Zheng, Zirui Liu, Meixue Pan, Yue Li, Bo Yu, Shaohua Chen, Jing Lai, Xianfeng Zha, Liye Zhong, Yikai Zhang, Yangqiu Li   +14 more
wiley   +1 more source

The ETS1-LINC00278 negative feedback loop plays a role in COL4A1/COL4A2 regulation in laryngeal squamous cell carcinoma.

Neoplasma (Bratislava), 2022
The present study aimed to investigate LINC00278 expression in laryngeal squamous cell carcinoma (LSCC) and its involvement in the process of proliferation, migration, and invasion, providing a rationale for mining potential diagnostic and therapeutic ...
Chuan Yang, H. Cao, Jianwang Yang, Jiantao Wang, Miao Yu, Baoshan Wang   +5 more
semanticscholar   +1 more source

Sphingosine‐1‐Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The tumor microenvironment in solid tumors is characterized by extracellular acidosis, which promotes cancer aggressiveness. In osteosarcoma, the most common primary bone cancer, a highly acidic tumor microenvironment is associated with metastasis and poor prognosis, partly due to metabolic rewiring, including changes in lipid pathways ...
Nicolò Bozzini, Margherita Cortini, Alberto Righi, Agamemnon E. Grigoriadis, Michael Dack, Elizabeta Ilieva, Federica Torricelli, Veronica Manicardi, Nicola Baldini, Sofia Avnet   +9 more
wiley   +1 more source

Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1 [PDF]

Oncogene, 2003
Cancer formation and progression is a complex process determined by several mechanisms that promote cell growth, invasiveness, neo-angiogenesis, and render neoplastic cells resistant to apoptosis. The tumor suppressor p53 and the proto-oncogenic factor ets-1 are important regulators of such mechanisms.
Ella, Kim, Willy, Günther, Kimio, Yoshizato, Hildegard, Meissner, Srenja, Zapf, Rolf M, Nüsing, Hirotaka, Yamamoto, Erwin G, Van Meir, Wolfgang, Deppert, Alf, Giese   +9 more
openaire   +2 more sources

ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells [PDF]

, 2014
The RAS/ERK pathway is commonly activated in carcinomas and promotes oncogenesis by altering transcriptional programs. However, the array of cis-regulatory elements and trans-acting factors that mediate these transcriptional changes is still unclear. Our
Budka, Justin A., Ferris, Mary W., Hollenhorst, Peter C., Plotnik, Joshua P.   +3 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, Volume 20, Issue 4, Page 877-893, April 2026.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Bushen Zhuanggu Formula promotes bone repair in nontraumatic osteonecrosis of the femoral head via regulating PKC-RAS-ERK-ETS1-RANKL signaling axis

Science of Traditional Chinese Medicine
Background:. Bushen Zhuanggu Formula (BZF), derived from the classic Yougui Pills, has shown favorable clinical efficacy in treating advanced nontraumatic osteonecrosis of the femoral head (NONFH), particularly by promoting bone repair.
Chu Zhang, Zhaochen Ma, Tao Li, Yudong Liu, Yan Jia, Qun Li, Chunfang Liu, Ya Lin, Chunzhu Gong, Na Lin, Weiheng Chen, Yanqiong Zhang   +11 more
doaj   +1 more source

LncRNAs: the bridge linking RNA and colorectal cancer. [PDF]

, 2016
Long noncoding RNAs (lncRNAs) are transcribed by genomic regions (exceeding 200 nucleotides in length) that do not encode proteins. While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, lncRNAs control ...
Chen, Yi, Deng, Xiangbing, Feng, Min, Lau, Bonnie, Lau, Wayne Bond, Le, Xiaobing, Lei, Lingzi, Luo, Zhongyue, Wang, Chenlu, Wei, Yuquan, Xu, Lian, Xuan, Yu, Yang, Huiliang, Yang, Qilian, Yang, Yanfei, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Shengtao   +18 more
core   +4 more sources

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Single-cell reconstruction of differentiation trajectory reveals a critical role of ETS1 in human cardiac lineage commitment

BMC Biology, 2019
Background Cardiac differentiation from human pluripotent stem cells provides a unique opportunity to study human heart development in vitro and offers a potential cell source for cardiac regeneration.
Hang Ruan, Yingnan Liao, Zongna Ren, Lin Mao, Fang Yao, Peng Yu, Youqiong Ye, Zhao Zhang, Shengli Li, Hanshi Xu, Jiewei Liu, Lixia Diao, Bingying Zhou, Leng Han, Li Wang   +14 more
doaj   +1 more source