Results 81 to 90 of about 116,033,210 (184)

Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges.
Marija Nikolovska, Radoslav Stojchevski, Aleksandar Eftimov, Mitko Mladenov, Dimiter Avtanski, Nikola Hadzi‐Petrushev   +5 more
wiley   +1 more source

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

Frontiers in Drug Discovery
As a key host protein involved in cellular infection by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), angiotensin converting enzyme (ACE)2 is an ideal target for antiviral drugs.
Liam M. Ashander, Amanda L. Lumsden, Yuefang Ma, Alwin Chun Rong Tan, Binoy Appukuttan, Santhosh Daniel, Santhosh Daniel, Michael Z. Michael, Michael Z. Michael, Justine R. Smith, Justine R. Smith   +10 more
doaj   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

PIM3 Proto-Oncogene Kinase Is a Common Transcriptional Target of Divergent EWS/ETS Oncoproteins

, 2003
Despite significant structural diversity, present evidence suggests that EWS/ETS fusion proteins promote oncogenesis by transcriptionally modulating a common set of target genes.
Welford, Scott M, Kurland, Irwin, Hernandez, Felicia, Ho, Thu, Denny, Christopher T, Deneen, Benjamin   +5 more
core   +1 more source

Immunohistochemical expression of Ets-related gene-transcriptional factor in adenocarcinoma prostate and its correlation with Gleason score

Indian Journal of Pathology and Microbiology, 2016
Background: Prostate carcinoma is the second leading cause of cancer-related deaths in males worldwide. The burden is expected to grow 1.7 million new cases and 499,000 new deaths by 2030.
Rahul Mannan, Tejinder Singh Bhasin, Mridu Manjari, Gagandeep Singh, Puneet Kaur Bhatia, Sonam Sharma   +5 more
doaj   +1 more source

JUND (JUN-D proto-oncogene)

, 2003
Review on JUND (JUN-D proto-oncogene), with data on DNA, on the protein encoded, and where the gene is ...
F Chen, Chen, F
core   +1 more source

Deep attention based Proto-oncogene prediction and Oncogene transition possibility detection using moments and position based amino acid features [PDF]

The loss of the regulatory function of tumor suppression genes and mutations in Proto-oncogene are the common underlying mechanisms for uncontrolled tumor growth in the varied complex of disorders known as cancer.
M. Vallinayagi, M. Vijayalakshmi
core   +1 more source

JUNB PROMOTER REGULATION - RAS MEDIATED TRANSACTIVATION BY C-ETS-1 AND C-ETS-2

, 1994
The Jun gene family encode components of the AP-1 transcription factor complex that regulate a variety of TRE-containing target promoters. Expression of family members is induced by a wide variety of extracellular stimuli and thought to be important in ...
GHYSDAEL, J, KRUIJER, W, DEJONGE, M, METTOUCHI, A, COFFER, P, BINETRUY, B   +5 more
core   +1 more source

Tet Methylcytosine Dioxygenase 3 Promotes Cardiovascular Senescence by DNA 5‐Hydroxymethylcytosine‐Mediated Sp1 Transcription Factor Expression

MedComm
Cellular senescence is a significant contributor to various age‐related diseases. Tet methylcytosine dioxygenase 3 (TET3) is a pivotal regulator of epigenetic modifications, and this study aimed to elucidate its role in cellular senescence.
Yanqi Dang, Jing Ma, Shuang Ling, Shurong Wang, Huining Guo, Jun Liu, Guang Ji, Jin‐Wen Xu   +7 more
doaj   +1 more source

Induction of C-Met Proto-Oncogene by Epstein-Barr Virus Latent Membrane Protein-1 and the Correlation with Cervical Lymph Node Metastasis of Nasopharyngeal Carcinoma

, 2009
Nasopharyngeal carcinoma (NPC) is distinctive in head and neck carcinomas for its close association with Epstein-Barr virus and Its highly metastatic nature. Up-regulation of cell motility Is essential for enhancement of metastatic potential.
沈宗憲, SHEEN, TZUNG-SHIAHN
core