Results 81 to 90 of about 13,787 (194)
The Prostate, Volume 86, Issue 10, Page 1103-1114, July 2026.ABSTRACT Background The management of intermediate‐risk early prostate cancer (PCa) is challenging due to the difficulty in distinguishing indolent from aggressive tumors. This study explores the association between genomic alterations and the tumor and its microenvironment (TME) and implications for disease progression. Methods We performed multi‐omic
William Lautert‐Dutra +13 more
wiley +1 more source
Analysis of the interaction of TIP60β and PIN1 with the ets family transcription factor ETV6 [PDF]
, 2005 The ETV6 gene is involved in many chromosomal translocations forming different fusion genes in both myeloid and lymphoid leukemias as well as in some solid tumors.
Zhang, Chang-Dong
core
A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley +1 more source
The Role of Sumoylation on the Regulation of Ets-1 [PDF]
, 2007 Ets-1 has been demonstrated to play some roles in the regulation of T lymphocytes, which including T cell development, differentiation and apoptosis. Recently, Ets-1 has been reported to be a modulator of T helper cell cytokine secreting profiles which ...
曹孝瑋, Tsao, Hsiao-Wei
core
Ets-1 expression and gemcitabine chemoresistance in pancreatic cancer cells [PDF]
, 2011 Gemcitabine, a novel pyrimidine nucleoside analog, has become the standard chemotherapeutic agent for pancreatic cancer patients. The clinical impact of gemcitabine remains modest owing to the high degree of inherent and acquired resistance.
Debarshi Chakrabarti +3 more
core +1 more source
MedCommCellular senescence is a significant contributor to various age‐related diseases. Tet methylcytosine dioxygenase 3 (TET3) is a pivotal regulator of epigenetic modifications, and this study aimed to elucidate its role in cellular senescence.
Yanqi Dang +7 more
doaj +1 more source
Role of Ets-1 in transcriptional regulation of transferrin receptor and erythroid differentiation [PDF]
High expression of transferrin receptor (TfR) on the membrane of erythroid cells accounts for the high level of iron required to sustain heme synthesis. Several studies indicate that during erythroid differentiation TfR expression is highly dependent on ...
Moret, R. +8 more
core +1 more source
Salsalate improves the anti-tumor efficacy of lenvatinib in MASH-driven hepatocellular carcinoma
JHEP ReportsBackground & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is a growing cause of hepatocellular carcinoma (HCC) worldwide. The complex microenvironment of these tumors, characterized by metabolic dysfunction, hypoxia, steatosis, and ...
Evangelia E. Tsakiridis +14 more
doaj +1 more source
HeliyonObjective: This study aimed to investigate the mechanism of long noncoding ribonucleic acid (lncRNA) SNHG16 on kidney clear cell carcinoma (KIRC) cells by targeting miR-506-3p/ETS proto-oncogene 1, transcription factor (ETS1)/RAS/Extracellular regulated ...
Tao Cheng +9 more
doaj +1 more source
Transcription Factor ETS-1 and Reactive Oxygen Species: Role in Vascular and Renal Injury [PDF]
, 2018 The E26 avian erythroblastosis virus transcription factor-1 (ETS-1) is a member of the ETS family and regulates the expression of a variety of genes including growth factors, chemokines and adhesion molecules. Although ETS-1 was discovered as an oncogene,
Edgar A. Jaimes +2 more
core +1 more source