Results 81 to 90 of about 29,837,514 (156)

p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells

, 2003
The negative-regulatory feedback loop between p53 and hdm2 forms part of a finely balanced regulatory network of proteins that controls cell cycle progression and commitment to apoptosis.
Phelps, Monika, Darley, Matthew, Primrose, John N., Blaydes, Jeremy P.   +3 more
core   +1 more source

Mechanism of lncRNA SNHG16 on kidney clear cell carcinoma cells by targeting miR-506-3p/ETS1/RAS/ERK molecular axis

Heliyon
Objective: This study aimed to investigate the mechanism of long noncoding ribonucleic acid (lncRNA) SNHG16 on kidney clear cell carcinoma (KIRC) cells by targeting miR-506-3p/ETS proto-oncogene 1, transcription factor (ETS1)/RAS/Extracellular regulated ...
Tao Cheng, Ming-Li Gu, Wei-Qiang Xu, Da-Wen Ye, Ze-Yu Zha, Wen-Ge Fang, Li-Kai Mao, Jing Ning, Xing-Bang Hu, Yong-Hui Ding   +9 more
doaj   +1 more source

ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma

Cell Death and Disease
Glioblastoma is a highly aggressive brain tumour that creates an immunosuppressive microenvironment. Microglia, the brain’s resident immune cells, play a crucial role in this environment.
Guillermo Vázquez-Cabrera, Martin Škandík, Noémie Roncier, Farah Real Oualit, Mireia Cruz De Los Santos, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph   +7 more
doaj   +1 more source

Single-cell identifies and validates human circulating Treg subtype/state Treg fci in non-small cell lung cancer

Signal Transduction and Targeted Therapy
Regulatory T cells (Treg) play immunosuppressive roles in lung cancer and are key biomarkers in cancer immunology. Using scRNA-seq and stereo-seq, we aimed to identify a novel circulating Treg subtype in non-small cell lung cancer (NSCLC). We developed a
Xuanqi Liu, Yifei Liu, Wanxin Duan, Jianming Weng, Hao Dai, Fangming Liu, Lingyan Wang, Mengjia Qian, Bijun Zhu, Shuyao Wu, Youqiong Ye, Muhan Yuan, Shaojun Hong, Mingjie Wang, Yunfeng Cheng, Tianxiang Chen, Duojiao Wu, Yuanlin Song, Xiangdong Wang   +18 more
doaj   +1 more source

Knocking down ETS Proto-oncogene 1 (ETS1) alleviates the pyroptosis of renal tubular epithelial cells in patients with acute kidney injury by regulating the NLR family pyrin domain containing 3 (NLRP3) transcription. [PDF]

Bioengineered, 2022
Juan C, Zhu Y, Chen Y, Mao Y, Zhou Y, Zhu W, Wang X, Wang Q.   +7 more
europepmc   +1 more source

MIAT promotes tumor-infiltrating CD8+ T-cell exhaustion and malignant progression of renal cell carcinoma via activating JAK3/STAT3 pathway

Journal for ImmunoTherapy of Cancer
Background The hyporesponsiveness of tumor-infiltrating exhausted CD8+ T cells to tumor cells contributes to immune escape of renal cell carcinoma (RCC), representing a major challenge in current immunotherapy. However, the underlying molecular mechanism
Bin Wang, Jian-Feng Wang, Jun-Hang Luo, Ming-xiao Zhang, Lan-yu Jing, Hao-tian Tan, Zi-ran Dai, Da-zhi Long, Han-chao Liu, An-ze Yu, Zi-yin Chen, Zhen-hua Chen   +11 more
doaj   +1 more source

Long Non-Coding RNA CASC19 Sponges microRNA-532 and Promotes Oncogenicity of Clear Cell Renal Cell Carcinoma by Increasing ETS1 Expression

Cancer Management and Research, 2020
Yu Luo, Feng Liu, Chunhui Yan, Wei Qu, Liang Zhu, Zheng Guo, Fan Zhou, Wei Zhang Department of Urology, The 161st Hospital of the People’s Liberation Army, Wuhan, Hubei 430010, People’s Republic of ChinaCorrespondence: Feng LiuDepartment of ...
Luo Y, Liu F, Yan C, Qu W, Zhu L, Guo Z, Zhou F, Zhang W   +7 more
doaj  

Transcription factor Ets-1 is essential for mesangial matrix remodeling [PDF]

, 2006
Most advanced glomerular diseases are characterized by abnormal extracellular matrix (ECM) accumulation in the glomeruli, and matrix metalloproteinases (MMPs) play a pivotal role in ECM remodeling in various glomerular diseases. The proto-oncogene, ets-1,
Sato, Y., Takahara, S., Imai, E., Shimizu, F., Mizui, M., Ito, T., Kawachi, H., Isaka, Y., Takabatake, Y.   +8 more
core   +1 more source

A prognostic risk prediction model for gastric cancer based on the EFNA4 and ETS1 regulatory axis in tumor cells

Scientific Reports
Gastric cancer (GC) is a major cause of cancer-related deaths worldwide, and is characterised by intricate molecular mechanisms. However, analysis of its molecular and clinical characteristics is complicated by its histological and etiological ...
Yixuan Chen, Ning Wang, Junkun Wang, Shupei Li, Wenchen Zhang, Wenjiang Deng, Jingjing Ye, Zhoujuan Yao, Hui Zhang, Fengsong Wang, Wenbin Wang   +10 more
doaj   +1 more source

Gene structure of the human MET proto-oncogene

, 1997
By direct sequencing of cosmids using primers designed from the known cDNA sequence, we identified 19 exons in the human MET proto-oncogene, and sequenced the corresponding 5' and 3' exon-intron junctions.
Scherer, SW, Lerman, MI, Zbar, B, Tsui, LC, Duh, FM, Schmidt, L   +5 more
core   +1 more source