Results 51 to 60 of about 13,787 (194)

The Interplay of M1 Macrophages and Dental Pulp Stem Cells Promotes Angiogenesis Through IL‐8‐Dependent VEGF Regulation: An In Vitro Study

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp inflammation triggers immune responses involving macrophages and dental pulp stem cells (DPSCs), which interact to regulate angiogenesis essential for tissue repair. M1 pro‐inflammatory macrophages predominate early in pulpitis, and clarifying their angiogenic role is vital in identifying inflammatory regenerative ...
Dineshi Sewvandi Thalakiriyawa, Mohamad Koohi‐Moghadam, Mingxin Hu, Hong Wang, Colman McGrath, Waruna Lakmal Dissanayaka   +5 more
wiley   +1 more source

Identification of Novel Interaction Partners of Ets-1: Focus on DNA Repair [PDF]

, 2019
International audienceThe transcription factor Ets-1 (ETS proto-oncogene 1) shows low expression levels except in specific biological processes like haematopoiesis or angiogenesis.
Guillaume Brysbaert, Marc F. Lensink, Lensink, Marc, Marc Aumercier, Ruyck, Jérôme,, Brysbaert, Guillaume, Jérôme de Ruyck, de Ruyck, Jerome, Aumercier, Marc   +8 more
core   +2 more sources

Super‐Enhancer‐Driven IRF2BP2 is Activated by Master Transcription Factors and Sustains T‐ALL Cell Growth and Survival

Advanced Science
Super enhancers (SEs) are large clusters of transcriptional enhancers driving the expression of genes crucial for defining cell identity. In cancer, tumor‐specific SEs activate key oncogenes, leading to tumorigenesis.
Juanjuan Yu, Zimu Zhang, Yanling Chen, Jianwei Wang, Gen Li, Yanfang Tao, Yongping Zhang, Yang Yang, Chenyue Zhang, Tiandan Li, Jia Cheng, Tongtign Ji, Zhongling Wei, Wenjuan Wang, Fang Fang, Wei Jiang, Peipei Chu, Hongli Yin, Di Wu, Xiaolu Li, Xiaodong Wang, Jun‐Jie Fan, Shaoyan Hu, Zhen‐Hong Zhu, Shuiyan Wu, Jun Lu, Jian Pan   +26 more
doaj   +1 more source

Sex‐Modulated TACSTD2 Methylation and Hormone‐Receptor Axis Interactions in Glioblastoma: Insights Toward Mechanistic Understanding

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
Sex‐stratified analyses of the TCGA and CGGA cohorts have identified promoter‐proximal TACSTD2 CpG sites where methylation shows opposite survival associations in males and females, is independent of copy number, and correlates with TACSTD2 expression.
Tahreem Fatima
wiley   +1 more source

Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1 [PDF]

Oncogene, 2003
Cancer formation and progression is a complex process determined by several mechanisms that promote cell growth, invasiveness, neo-angiogenesis, and render neoplastic cells resistant to apoptosis. The tumor suppressor p53 and the proto-oncogenic factor ets-1 are important regulators of such mechanisms.
Ella, Kim, Willy, Günther, Kimio, Yoshizato, Hildegard, Meissner, Srenja, Zapf, Rolf M, Nüsing, Hirotaka, Yamamoto, Erwin G, Van Meir, Wolfgang, Deppert, Alf, Giese   +9 more
openaire   +2 more sources

Transcriptional regulation of ETV5 by mitogen-activated protein kinase via ETS-1 in human pancreatic cancer cells

Scientific Reports
Pancreatic cancer is characterized by constitutive activation of mitogen-activated protein kinase /extracellular signal-regulated kinase 1/2 (ERK1/2) driven by gain-of-function mutations of KRAS. Our previous transcriptome sequencing of ERK1/2-attenuated
Aya Noguchi, Masanobu Kimura, Yuriko Saiki, Tomohiko Ishikawa, Takashi Kokumai, Yuko Omori, Yusuke Ono, Yusuke Miszukami, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Michiaki Unno, Toru Furukawa   +12 more
doaj   +1 more source

Bushen Zhuanggu Formula promotes bone repair in nontraumatic osteonecrosis of the femoral head via regulating PKC-RAS-ERK-ETS1-RANKL signaling axis

Science of Traditional Chinese Medicine
Background:. Bushen Zhuanggu Formula (BZF), derived from the classic Yougui Pills, has shown favorable clinical efficacy in treating advanced nontraumatic osteonecrosis of the femoral head (NONFH), particularly by promoting bone repair.
Chu Zhang, Zhaochen Ma, Tao Li, Yudong Liu, Yan Jia, Qun Li, Chunfang Liu, Ya Lin, Chunzhu Gong, Na Lin, Weiheng Chen, Yanqiong Zhang   +11 more
doaj   +1 more source

Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression

Journal of Experimental & Clinical Cancer Research, 2019
Background Gliomas are common life-threatening cancers, mainly due to their aggressive nature and frequent invasiveness and long non-coding RNAs (lncRNAs) are emerging as promising molecular targets.
Haiyang Xu, Guifang Zhao, Yu Zhang, Hong Jiang, Weiyao Wang, Donghai Zhao, Hongquan Yu, Ling Qi   +7 more
doaj   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma [PDF]

, 2011
MicroRNAs-221 and -222 are highly upregulated in several solid tumors, including melanomas. We demonstrate that the proto-oncogene ETS-1, involved in the pathogenesis of cancers of different origin, is a transcriptional regulator of miR-222 by direct ...
and Colombo MP, Gianfranco Mattia, and Felicetti F, Lisabianca Bottero, and Tomasello L, Marina Petrini, M. Cristina Errico, Alessandra Carè, Antonio Di Virgilio, Mattia G, Alessandra Boe, Mario P. Colombo, and Errico MC, and di Virgilio A, and Carè A., Luisa Tomasello, and Bottero L, and Segnalini P, Paolo Romania, Federica Felicetti, and Petrini M, Patrizia Segnalini, Romania P, and Boe A   +23 more
core   +1 more source