Results 51 to 60 of about 30,453 (235)

The Nefarious Nexus of Noncoding RNAs in Cancer [PDF]

, 2018
The past decade has witnessed enormous progress, which has seen the noncoding RNAs (ncRNAs) turn from the so called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts.
Anastasiadou, Eleni, Faggioni, Alberto, J Slack, Frank, Trivedi, Pankaj   +3 more
core   +1 more source

Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research, 2022
Background Drug resistance to sorafenib greatly limited the benefits of treatment in patients with hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) participate in the development of drug resistance.
Yuanjun Lu, Yau-Tuen Chan, Hor-Yue Tan, Cheng Zhang, Wei Guo, Yu Xu, Rakesh Sharma, Zhe-Sheng Chen, Yi-Chao Zheng, Ning Wang, Yibin Feng   +10 more
doaj   +1 more source

HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1

Nature Communications, 2021
N6,2′-O-dimethyladenosine (m6Am) is an abundant RNA modification located adjacent to the 5′-end of the mRNA 7-methylguanosine (m7G) cap structure.
Qiong Zhang, Yuqi Kang, Shaobo Wang, G. Gonzalez, Wanyu Li, Hui Hui, Yinsheng Wang, T. Rana   +7 more
semanticscholar   +1 more source

Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: Identification of the c-myc regulatory gene network [PDF]

, 2008
BACKGROUND: The transcriptional regulator c-Myc is the most frequently deregulated oncogene in human tumors. Targeted overexpression of this gene in mice results in distinct types of lung adenocarcinomas.
A Menssen, AE Kel, AH Lund, AM Lefebvre, B Amati, B Vogelstein, C Bello-Fernandez, C Brenner, CE Nesbit, CE Nesbit, CJ Lee, D Levens, D Remondini, D Tantin, DE Brough, E Wingender, EF Wagner, EM Blackwood, F Parisi, F Wu, GF Claassen, H Braun, H Sato, HA Coller, HF Frierson Jr, J Hayakawa, J Kaplan, J Miethe, JD Watson, JD Watson, JP Frederick, JP Whitlock Jr, JV Falvo, Jürgen Borlak, K Basso, K Boon, K Quandt, K Tamura, K Yokoro, K Zhao, KH Kaestner, KI Zeller, KI Zeller, KM Hsiao, KS Imai, LJ Wood, M Abdelrahim, M Bar-Ner, M Harrer, M Henriksson, M Mahlapuu, M Numoto, M Schuhmacher, MD Cole, MJ Birnbaum, MJ McConnell, N Yamakawa-Karakida, NA Jensen, O Schuldiner, QM Guo, R Elkon, RA Gupta, RC Sears, S Decary, S Gaubatz, S Gupta, S Pelengaris, SG Ahn, SK Lim, SL Coleman, Susanne Reymann, SW Hiebert, T Bowman, T Hsu, T Moroy, T Oikawa, T Suzuki, TJ Haggerty, VV Kalinichenko, X Zhang, Y Chen, Y Tamimi, Z Li   +82 more
core   +2 more sources

ETS-1 Expression Is Hypoxia-independent in Glioblastoma-derived Endothelial and Mesenchymal Stem-like Cells

Anticancer Research, 2018
Background: Tumor cells infiltrating the brain are a typical hallmark of glioblastoma. Invasiveness of glioma cells has been associated with ETS proto-oncogene 1 (ETS-1). In non-glial tumors, ETS-1 expression has been linked to hypoxia.
Dominik Koessinger, V. Albrecht, Florian Faber, Irene Jaehnert, C. Schichor   +4 more
semanticscholar   +1 more source

HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer [PDF]

, 2017
Homeobox (HOX) genes are conserved transcription factors which determine the anterior-posterior body axis patterning. HOXD8 is a member of HOX genes deregulated in several tumors such as lung carcinoma, neuroblastoma, glioma and colorectal cancer (CRC ...
Mansour, Mohammed A., Senga, Takeshi
core   +1 more source

Pigment Intensity in Dogs is Associated with a Copy Number Variant Upstream of KITLG. [PDF]

, 2020
Dogs exhibit a wide variety of coat color types, and many genes have been identified that control pigment production, appearance, and distribution. Some breeds, such as the Nova Scotia Duck Tolling Retriever (NSDTR), exhibit variation in pheomelanin ...
Affolter, Verena, Bannasch, Danika, Grahn, Robert, Kallenberg, Angelica, Rebhun, Robert, Weich, Kalie, York, Daniel   +6 more
core   +2 more sources

Identification of Novel Interaction Partners of Ets-1: Focus on DNA Repair

Genes, 2019
The transcription factor Ets-1 (ETS proto-oncogene 1) shows low expression levels except in specific biological processes like haematopoiesis or angiogenesis. Elevated levels of expression are observed in tumor progression, resulting in Ets-1 being named
G. Brysbaert, J. de Ruyck, M. Aumercier, M. Lensink   +3 more
semanticscholar   +1 more source

Long Noncoding RNA LINC01426 Sequesters microRNA-519d-5p to Promote Non-Small Cell Lung Cancer Progression by Increasing ETS1 Expression [Expression of Concern]

Cancer Management and Research, 2021
Dai J, Wang B, Zhao Y, et al. Cancer Manag Res. 2020;12:12697–12708. The Editor and Publisher of Cancer Management and Research wish to publish an Expression of Concern for the published article.
Dai J, Wang B, Zhao Y, Zuo X, Cui H, Chen X, Liu X   +6 more
doaj  

Analyses of domains and domain fusions in human proto-oncogenes [PDF]

, 2009
Background Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers.
Qi Liu, Jinling Huang, Huiqing Liu, Ping Wan, Xiuzi Ye, Ying Xu   +5 more
core   +1 more source