Results 41 to 50 of about 116,033,210 (184)

ETV6 (ETS variant gene 6 (TEL oncogene)) [PDF]

, 2005
Review on ETV6 (ETS variant gene 6 (TEL oncogene)), with data on DNA, on the protein encoded, and where the gene is ...
Knezevich, S
core   +1 more source

Inherited platelet dysfunction and hematopoietic transcription factor mutations

Platelets, 2017
Transcription factors (TFs) are proteins that bind to specific DNA sequences and regulate expression of genes. The molecular and genetic mechanisms in most patients with inherited platelet dysfunction are unknown.
Natthapol Songdej, A. Koneti Rao
doaj   +1 more source

Patient‐specific genomic measurable residual disease markers for monitoring acute myeloid leukaemia and myeloid malignancy

British Journal of Haematology, EarlyView.
Standardised DNA based measurable residual disease (MRD) monitoring is possible for acute myeloid leukaemia (AML) and myeloid malignancy patients. Targeted next‐generation sequencing (NGS) and RNA‐seq permit marker development for clinically identified lesions and whole genome sequencing (WGS) permits MRD marker development in patients without ...
Libby Huang, Louise Doculara, Luis Enriquez, Jodie Giles, Umma Habiba, Anita Y. Bahar, Tammy Law, Weronika Lesnowolska, Hannah McCalmont, Erika Ong, Laura Piras, Benjamin Schreiber, Nicola Venn, Wiebke Wessels, Yianni Bletas, Minjina Kang, Sam Yuen, Patrick Strong, Paulette Barahona, Ann‐Kristin Altekoester, Kimberly Dias, Dianne Sylvester, Marie Erasmus Wong, Renee Eslick, Luciano Dalla Pozza, Bhavna Padhye, Ashanka Beligaswatte, Chow Yee Lai, Michelle Ng, Chris Fraser, David Hughes, Seong Lin Khaw, Karen McCleary, Sophie Jessop, Manika Pal, Lucie Winkowska, Jan Zuna, Patrizia Larghero, Rolf Marschalek, Claus Meyer, Rishi S. Kotecha, Andrew S. Moore, Mark J. Cowley, Rosemary Sutton, Michelle J. Henderson, Toby N. Trahair   +45 more
wiley   +1 more source

Alternative splicing within the chicken c-ets-1 locus: implications for transduction within the E26 retrovirus of the c-ets proto-oncogene [PDF]

Journal of Virology, 1988
Two overlapping c-ets-1 cDNA clones were isolated which contained the alpha and beta genomic sequences homologous to the 5' end of v-ets not detected in the previously described c-ets RNA species or proteins. Nucleotide sequencing demonstrated that these cDNAs corresponded to the splicing of alpha and beta to a common set of 3' exons (a through F ...
D, Leprince, M, Duterque-Coquillaud, R P, Li, C, Henry, A, Flourens, B, Debuire, D, Stehelin   +6 more
openaire   +2 more sources

JUNB (jun B proto-oncogene) [PDF]

, 2003
Review on JUNB (jun B proto-oncogene), with data on DNA, on the protein encoded, and where the gene is ...
Chen, F
core   +1 more source

ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy

Molecular Medicine, 2021
Background Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. The endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells has been reported to play a crucial role in DN.
Lihong Lu, Ziwen Zhong, Jiahui Gu, Ke Nan, Minmin Zhu, Changhong Miao   +5 more
doaj   +1 more source

TERT Promoter Mutations Are Preferentially Associated With the ERBB2 G776‐Altered Subtype of HER2‐Mutant NSCLC

Cancer Science, EarlyView.
A two‐stage clinicogenomic analysis identified and independently validated a preferential association between TERT promoter mutations and the ERBB2 G776‐altered subtype of HER2‐mutant NSCLC, highlighting subtype‐specific genomic heterogeneity. ABSTRACT HER2‐mutant non‐small cell lung cancer (NSCLC) comprises molecularly heterogeneous tumors with ...
Akihiro Yoshimura, Juichiro Yoshida, Chieko Takumi, Koichi Takayama   +3 more
wiley   +1 more source

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

UV signature mutation hyperhotspots as genomic dosimeters

Photochemistry and Photobiology, EarlyView.
Recurrent UV signature mutations are a sensitive and specific indicator of sun exposure. UV signature mutations (C → T mutations at dipyrimidine sites) were quantified using Duplex Sequencing and a stringent mutation calling protocol to identify true low‐abundance mutations.
Vijay Menon, Alejandro García‐Ruiz, Susan Neveu, Brenda Cartmel, Leah M. Ferrucci, Meg Palmatier, Christine Ko, Kenneth Y. Tsai, Mio Nakamura, Sa Rang Kim, Michael Girardi, Karl Kornacker, Douglas E. Brash   +12 more
wiley   +1 more source

Long Noncoding RNA LINC01426 Sequesters microRNA-519d-5p to Promote Non-Small Cell Lung Cancer Progression by Increasing ETS1 Expression

Cancer Management and Research, 2020
Jixin Dai,1 Bing Wang,2 Yueming Zhao,1 Xuerong Zuo,1 Hongxia Cui,1 Xi Chen,2 Xianhong Liu1 1Department of Oncology, Jilin Cancer Hospital, Changchun, Jilin 130000, People’s Republic of China; 2Department of Radiotherapy, Jilin Cancer Hospital ...
Dai J, Wang B, Zhao Y, Zuo X, Cui H, Chen X, Liu X   +6 more
doaj