Results 21 to 30 of about 13,787 (194)

Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells [PDF]

, 2009
Background Transplantation of vasculogenic progenitor cells (VPC) improves neovascularization after ischemia. However, patients with type 2 diabetes mellitus show a reduced VPC number and impaired functional activity. Previously, we demonstrated that p38
Aicher Alexandra, Chen Linping, Seeger Florian Hartmut, Altschmied Joachim, Haendeler Judith, Alexandra Aicher, Aicher, Alexandra, Judith Haendeler, Seeger, Florian Hartmut, Chen, Linping, Haendeler, Judith, Florian Hartmut Seeger, Linping Chen, Joachim Altschmied, Spyridopoulos Ioakim, Spyridopoulos, Ioakim, Altschmied, Joachim, Ioakim Spyridopoulos   +17 more
core   +1 more source

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2 [PDF]

, 2015
Ets-2, like its closely related homologue Ets-1, is a member of the Ets family of DNA binding transcription factors. Both proteins are subject to multiple levels of regulation of their DNA binding and transactivation properties.
Gileadi, Opher, Cooper, Christopher D.O., Newman, Joseph A., Aitkenhead, Hazel   +3 more
core   +1 more source

Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice [PDF]

, 2000
The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating factor 1 (CSF-1)- and mitogen-activated protein kinase-independent manner in macrophages isolated from motheaten-viable (me-v) mice.
Forsthoefel, David, Ostrowski, M C, Hartman, M, Schaffner, A E, Smith, James L., Hume, D A, Smith, J L, Ostrowski, Michael C., Wei, G, Hofmeister, Joseph K., Hofmeister, J K, Schaffner, Alicia E., Wei, Guo, Hume, David A., Hartman, Matthew, Hartman, Matthew Hartman, Forsthoefel, D   +16 more
core   +1 more source

Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma

Journal of Innate Immunity, 2020
Children exposed to common aeroallergens may develop asthma that progresses into adulthood. Inflammation regulated by T helper 2 (Th2) cells, a specific subpopulation of CD4+ T lymphocytes, is involved in asthmatic injury.
Tianyue  Wang, Qianlan Zhou, Yunxiao Shang   +2 more
doaj   +1 more source

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition. [PDF]

, 2014
The Ets family of eukaryotic transcription factors is based around the conserved Ets DNA-binding domain. Although their DNA-binding selectivity is biochemically and structurally well characterized, structures of homodimeric and ternary complexes point to
Gileadi, Opher, Newman, JA, Cooper, CD, Joseph A Newman, Gileadi, O, Cooper, Christopher D.O., Christopher D O Cooper, Newman, Joseph A., Opher Gileadi   +8 more
core   +1 more source

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation. [PDF]

, 2015
Ets transcription factors, which share the conserved Ets DNA-binding domain, number nearly 30 members in humans and are particularly involved in developmental processes.
Allerston, Charles K., Gileadi, Opher, Cooper, Christopher D.O., Newman, Joseph A., Aitkenhead, Hazel   +4 more
core   +2 more sources

LINC00704 contributes to the proliferation and accelerates the cell cycle of nasopharyngeal carcinoma cells via regulating ETS1/CDK6 axis

Kaohsiung Journal of Medical Sciences, 2022
This study is aimed at exploring the biological functions and related mechanism of long noncoding RNA 704 (LINC00704) in the proliferation and cell cycle progression of nasopharyngeal carcinoma (NPC) cells.
Yan Wang, Qi‐Yan Tan, Ying Shen, Chang‐Yu Liu, Tao Huang, De Huai, Jun Dai   +6 more
doaj   +1 more source

SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma

Discover Oncology, 2022
Background Spi-1 proto-oncogene (SPI1), which encodes an ETS-domain transcription factor, can activate gene expression in myeloid and lymphoid lineages.
Huayi Feng, Tao Wang, Jiali Ye, Yang Yang, Xing Huang, Dong Lai, Zheng Lv, Yan Huang, Xu Zhang   +8 more
doaj   +1 more source

MicroRNA-769-5p Inhibits Pancreatic Ductal Adenocarcinoma Progression by Directly Targeting and Downregulating ETS Proto-Oncogene 1.

Onco Targets Ther, 2019
MicroRNA-769-5p (miR-769) is aberrantly expressed and plays crucial roles in non-small cell lung cancer and melanoma. However, the expression pattern, biological role, and mechanisms of action of miR-769 in pancreatic ductal adenocarcinoma (PDAC) are yet to be fully elucidated.
Cheng K, Feng L, Yu S, Yu C, Chi N.
europepmc   +4 more sources

ETS1 (v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)) [PDF]

, 2010
Review on ETS1 (v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)), with data on DNA, on the protein encoded, and where the gene is ...
Lindstrot, A, Wernert, N, Langer, B, B Langer, N Wernert, A Lindstrot   +5 more
core   +1 more source