Results 21 to 30 of about 30,453 (235)

LINC00704 contributes to the proliferation and accelerates the cell cycle of nasopharyngeal carcinoma cells via regulating ETS1/CDK6 axis

Kaohsiung Journal of Medical Sciences, 2022
This study is aimed at exploring the biological functions and related mechanism of long noncoding RNA 704 (LINC00704) in the proliferation and cell cycle progression of nasopharyngeal carcinoma (NPC) cells.
Yan Wang, Qi‐Yan Tan, Ying Shen, Chang‐Yu Liu, Tao Huang, De Huai, Jun Dai   +6 more
doaj   +2 more sources

ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy

Molecular Medicine, 2021
Background Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. The endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells has been reported to play a crucial role in DN.
Lihong Lu, Ziwen Zhong, Jiahui Gu, Ke Nan, Minmin Zhu, Changhong Miao   +5 more
doaj   +2 more sources

Proto-Oncogene Ets-1 and the Kidney [PDF]

Nephron, 2001
Most forms of advanced glomerular diseases, if not all, are characterized by abnormal turnover of extracellular matrix (ECM) proteins in glomeruli, resulting in structural alterations of glomerular basement membrane and mesangial matrix, usually leading to proteinuria. It is, therefore, important to elucidate the regulatory mechanisms of ECM metabolism
Mohammed S. Razzaque, Takashi Naito, Takashi Taguchi   +2 more
openalex   +3 more sources

Super‐Enhancer‐Driven IRF2BP2 is Activated by Master Transcription Factors and Sustains T‐ALL Cell Growth and Survival

Advanced Science
Super enhancers (SEs) are large clusters of transcriptional enhancers driving the expression of genes crucial for defining cell identity. In cancer, tumor‐specific SEs activate key oncogenes, leading to tumorigenesis.
Juanjuan Yu, Zimu Zhang, Yanling Chen, Jianwei Wang, Gen Li, Yanfang Tao, Yongping Zhang, Yang Yang, Chenyue Zhang, Tiandan Li, Jia Cheng, Tongtign Ji, Zhongling Wei, Wenjuan Wang, Fang Fang, Wei Jiang, Peipei Chu, Hongli Yin, Di Wu, Xiaolu Li, Xiaodong Wang, Jun‐Jie Fan, Shaoyan Hu, Zhen‐Hong Zhu, Shuiyan Wu, Jun Lu, Jian Pan   +26 more
doaj   +2 more sources

Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression

Journal of Experimental & Clinical Cancer Research, 2019
Background Gliomas are common life-threatening cancers, mainly due to their aggressive nature and frequent invasiveness and long non-coding RNAs (lncRNAs) are emerging as promising molecular targets.
Haiyang Xu, Guifang Zhao, Yu Zhang, Hong Jiang, Weiyao Wang, Donghai Zhao, Hongquan Yu, Ling Qi   +7 more
doaj   +2 more sources

Gut microbes–spinal connection is required for itch sensation

Gut Microbes
The gut microbiota has been linked to a number of neurological disorders. However, it is unclear whether the gut microbiota is involved in the genesis of chronic itch, a refractory condition that afflicts patients both physically and mentally.
Tong Jin, Si-Yuan Li, Hong-Li Zheng, Xiao-Dan Liu, Yue Huang, Gan Ma, Ya-Xuan Zhao, Xiao-Tian Zhao, Li Yang, Qi-Hui Wang, Hong-Jun Wang, Chengyong Gu, Zhiqiang Pan, Fuqing Lin   +13 more
doaj   +2 more sources

Expression of the Ets-1 Proto-Oncogene in Melanocytic Lesions [PDF]

Modern Pathology, 2003
Ets-1 oncoprotein is a transcription factor known to regulate the expression of numerous genes important in extracellular matrix remodeling and angiogenesis. Up-regulation of Ets-1 has been shown to be important in a variety of human malignancies and to correlate with prognosis.
Connie A. Keehn, Bruce R. Smoller, Michael B Morgan   +2 more
openalex   +4 more sources

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

Frontiers in Drug Discovery
As a key host protein involved in cellular infection by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), angiotensin converting enzyme (ACE)2 is an ideal target for antiviral drugs.
Liam M. Ashander, Amanda L. Lumsden, Yuefang Ma, Alwin Chun Rong Tan, Binoy Appukuttan, Santhosh Daniel, Santhosh Daniel, Michael Z. Michael, Michael Z. Michael, Justine R. Smith, Justine R. Smith   +10 more
doaj   +2 more sources

Mechanism of lncRNA SNHG16 on kidney clear cell carcinoma cells by targeting miR-506-3p/ETS1/RAS/ERK molecular axis

Heliyon
Objective: This study aimed to investigate the mechanism of long noncoding ribonucleic acid (lncRNA) SNHG16 on kidney clear cell carcinoma (KIRC) cells by targeting miR-506-3p/ETS proto-oncogene 1, transcription factor (ETS1)/RAS/Extracellular regulated ...
Tao Cheng, Ming-Li Gu, Wei-Qiang Xu, Da-Wen Ye, Ze-Yu Zha, Wen-Ge Fang, Li-Kai Mao, Jing Ning, Xing-Bang Hu, Yong-Hui Ding   +9 more
doaj   +2 more sources

The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1. [PDF]

EMBO Journal, 1990
Rémy Bosselut, Janet F. Duvall, Anne Gégonne, M Bailly, Agnès Hémar, John Brady, Jacques Ghysdael   +6 more
openalex   +3 more sources