Results 1 to 10 of about 30,453 (235)

Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons [PDF]

Molecular Pain, 2023
Nerve injury can induce aberrant changes in ion channels, enzymes, and cytokines/chemokines in the dorsal root ganglia (DRGs); these changes are due to or at least partly governed by transcription factors that contribute to the genesis of neuropathic ...
Hong-Li Zheng, Shi-Yu Sun, Tong Jin, Ming Zhang, Ying Zeng, Qiaoqiao Liu, Kehui Yang, Runa Wei, Zhiqiang Pan, Fuqing Lin   +9 more
doaj   +6 more sources

ETS proto-oncogene 1 modulates PTP1B expression to participate in high glucose-mediated endothelial inflammation [PDF]

Acta Biochimica et Biophysica Sinica, 2022
Hyperglycemia-induced endothelial inflammation participates in the pathogenesis of cardiovascular complications in diabetics. Previous studies showed that protein tyrosine phosphatase 1B (PTP1B) and ETS proto-oncogene 1 (ets1) are involved in ...
Jiang Lili, Liang Jincai, Wang Tianhai, Meng Fufen, Duan Wenming   +4 more
doaj   +6 more sources

ETS Proto-Oncogene 1-activated muskelin 1 antisense RNA drives the malignant progression of hepatocellular carcinoma by targeting miR-22-3p to upregulate ETS Proto-Oncogene 1. [PDF]

Bioengineered, 2022
Long noncoding RNA muskelin 1 antisense RNA (MKLN1-AS) acted as an oncogenic regulator in hepatocellular carcinoma (HCC). This study was performed to investigate the functional mechanism of MKLN1-AS.
Pan G, Zhang J, You F, Cui T, Luo P, Wang S, Li X, Yuan Q.   +7 more
europepmc   +8 more sources

ETS Proto-Oncogene 1 Suppresses MicroRNA-128 Transcription to Promote Osteogenic Differentiation Through the HOXA13/β-Catenin Axis [PDF]

Frontiers in Physiology, 2021
ETS proto-oncogene 1 (ETS1) has been implicated in osteoporosis (OP), but the exact molecular mechanisms are complex. This work focuses on the impact of ETS1 on the osteogenic differentiation and the molecules involved.
Renyao Li, Ying Dong, Feipeng Li
doaj   +7 more sources

Circular RNA_0000326 promotes bladder cancer progression via microRNA-338-3p/ETS Proto-Oncogene 1/phosphoinositide-3 kinase/Akt pathway. [PDF]

Bioengineered, 2021
Circular RNAs (circRNAs) play a pivotal regulatory role in bladder cancer (BC) occurrence and progression. The expression level, role and mechanism of circ_0000326 in BC remain unknown.
Chen Y, Wang D, Shu T, Sun K, Zhao J, Wang M, Huang Y, Wang P, Zheng H, Cai Z, Yang Z.   +10 more
europepmc   +6 more sources

ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. [PDF]

J Biol Chem, 2017
Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory cholangiopathy (disease of the bile ducts) of unknown pathogenesis. We reported that cholangiocyte senescence features prominently in PSC and that neuroblastoma RAS viral oncogene ...
O'Hara SP, Splinter PL, Trussoni CE, Pisarello MJ, Loarca L, Splinter NS, Schutte BF, LaRusso NF.   +7 more
europepmc   +7 more sources

MicroRNA-769-5p Inhibits Pancreatic Ductal Adenocarcinoma Progression by Directly Targeting and Downregulating ETS Proto-Oncogene 1 [Retraction]. [PDF]

Onco Targets Ther, 2021
[This retracts the article DOI: 10.2147/OTT.S218876.].
Kai Cheng, Lan Feng, Yu Shuang, Changhong Yu, Nannan Chi   +4 more
europepmc   +6 more sources

MicroRNA-769-5p Inhibits Pancreatic Ductal Adenocarcinoma Progression by Directly Targeting and Downregulating ETS Proto-Oncogene 1.

Onco Targets Ther, 2019
Purpose MicroRNA-769-5p (miR-769) is aberrantly expressed and plays crucial roles in non–small cell lung cancer and melanoma. However, the expression pattern, biological role, and mechanisms of action of miR-769 in pancreatic ductal adenocarcinoma (PDAC)
Cheng K, Feng L, Yu S, Yu C, Chi N.
europepmc   +7 more sources

Knocking down ETS Proto-oncogene 1 (ETS1) alleviates the pyroptosis of renal tubular epithelial cells in patients with acute kidney injury by regulating the NLR family pyrin domain containing 3 (NLRP3) transcription. [PDF]

Bioengineered, 2022
Acute kidney injury (AKI) has a high mortality rate, but its pathogenesis remains unclear Lipopolysaccharide (LPS)-mediated renal tubular epithelial pyroptosis is involved in the pathogenesis of AKI. NLR family of pyrin domains containing 3 (NLRP3) plays
Juan C, Zhu Y, Chen Y, Mao Y, Zhou Y, Zhu W, Wang X, Wang Q.   +7 more
europepmc   +4 more sources

Transcriptional regulation of ETV5 by mitogen-activated protein kinase via ETS-1 in human pancreatic cancer cells [PDF]

Scientific Reports
Pancreatic cancer is characterized by constitutive activation of mitogen-activated protein kinase /extracellular signal-regulated kinase 1/2 (ERK1/2) driven by gain-of-function mutations of KRAS. Our previous transcriptome sequencing of ERK1/2-attenuated
Aya Noguchi, Masanobu Kimura, Yuriko Saiki, Tomohiko Ishikawa, Takashi Kokumai, Yuko Omori, Yusuke Ono, Yusuke Miszukami, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Michiaki Unno, Toru Furukawa   +12 more
doaj   +3 more sources