ETS proto-oncogene 1 modulates PTP1B expression to participate in high glucose-mediated endothelial inflammation [PDF]
Acta Biochimica et Biophysica Sinica, 2022 Hyperglycemia-induced endothelial inflammation participates in the pathogenesis of cardiovascular complications in diabetics. Previous studies showed that protein tyrosine phosphatase 1B (PTP1B) and ETS proto-oncogene 1 (ets1) are involved in ...
Jiang Lili +4 more
doaj +6 more sources
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons [PDF]
Molecular Pain, 2023 Nerve injury can induce aberrant changes in ion channels, enzymes, and cytokines/chemokines in the dorsal root ganglia (DRGs); these changes are due to or at least partly governed by transcription factors that contribute to the genesis of neuropathic ...
Zhiqiang Pan, Kehui Yang, Fuqing Lin
exaly +5 more sources
ETS Proto-Oncogene 1-activated muskelin 1 antisense RNA drives the malignant progression of hepatocellular carcinoma by targeting miR-22-3p to upregulate ETS Proto-Oncogene 1 [PDF]
Bioengineered, 2022 Long noncoding RNA muskelin 1 antisense RNA (MKLN1-AS) acted as an oncogenic regulator in hepatocellular carcinoma (HCC). This study was performed to investigate the functional mechanism of MKLN1-AS. MKLN1-AS, microRNA-22-3p (miR-22-3p) and ETS Proto-Oncogene 1 (ETS1) levels were examined using reverse transcription-quantitative polymerase-chain ...
Tao Cui, Luo Peng
exaly +7 more sources
ETS Proto-Oncogene 1 Suppresses MicroRNA-128 Transcription to Promote Osteogenic Differentiation Through the HOXA13/β-Catenin Axis [PDF]
Frontiers in Physiology, 2021 ETS proto-oncogene 1 (ETS1) has been implicated in osteoporosis (OP), but the exact molecular mechanisms are complex. This work focuses on the impact of ETS1 on the osteogenic differentiation and the molecules involved.
Renyao Li, Ying Dong, Feipeng Li
doaj +5 more sources
The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1 [PDF]
Gastroenterology, 2023 We reported that cholangiocyte senescence, regulated by the transcription factor ETS proto-oncogene 1 (ETS1), is a pathogenic feature of primary sclerosing cholangitis (PSC). Furthermore, histone 3 lysine 27 is acetylated at senescence-associated loci.
Steven O'Hara +2 more
exaly +4 more sources
rSjP40 Inhibited the Activity of Collagen Type I Promoter via Ets-1 in HSCs
Frontiers in Cell and Developmental Biology, 2021 Liver fibrosis is a severe disease characterized by excessive deposition of extracellular matrix (ECM) components in the liver. Activated hepatic stellate cells (HSCs) are a major source of ECM and a key regulator of liver fibrosis. Collagen type I alpha
Jing Li +10 more
doaj +1 more source
Bioinformatics network analyses of growth differentiation factor 11
Open Life Sciences, 2022 Growth differentiation factor 11 (GDF11) has been implicated in rejuvenating functions in age-related diseases. The molecular mechanisms connecting GDF11 with these anti-aging phenomena, including reverse age-related cardiac hypertrophy and vascular and ...
Zhang Feng, Yang Xia, Bao Zhijun
doaj +1 more source
Romanian Journal of Internal Medicine, 2022 Introduction: The microRNA-326 (miR-326) gene, by targeting ETS Proto-Oncogene 1 (ETS1), regulates the differentiation and interleukin-17A production of T helper 17 (Th17) cells.
Nafari Maedeh +7 more
doaj +1 more source
Hypoxia stimulates angiogenesis and a metabolic switch in human parathyroid adenoma cells
Endocrine Oncology, 2023 Hypoxia, a primary stimulus for angiogenesis, is important for tumour proliferation and survival. The effects of hypoxia on parathyroid tumour cells, which may also be important for parathyroid autotransplantation in patients, are, however, unknown.
K E Lines +8 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2017 Background/Aims: Renal tubular epithelial-mesenchymal transition (EMT) is regarded as an important factor leading to renal interstitial fibrosis. Erythropoietin (EPO) has been reported to attenuate renal fibrosis. The mechanism underlying this protective
Jiuxu Bai +6 more
doaj +1 more source