Results 11 to 20 of about 30,453 (235)

ETS proto-oncogene 1 transcription factor is differentially expressed in lymph node metastasis in human breast cancer.

, 2021
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes.
Shahan Mamoor
semanticscholar   +4 more sources

Dasatinib Inhibits Basal B Breast Cancer Through ETS1-Mediated Extracellular Matrix Remodeling [PDF]

Biomedicines
Background/Objectives: Developing effective therapies for patients with triple-negative breast cancer (TNBC) remains an urgent clinical priority. Compared with other subtypes, the basal B type of TNBC exhibits a less differentiated and mesenchymal-like ...
Xinyu Guo, Heng Sun, Feng Yu, Yangyang Feng, Sen Guo, Josh Haipeng Lei, Kai Miao, Ka-U Ip, Ling Li, Hanghang Li, Xiaohong Liao, Xiaoling Xu, Rong Zhou, Chu-Xia Deng   +13 more
doaj   +3 more sources

The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1. [PDF]

Gastroenterology, 2023
We reported that cholangiocyte senescence, regulated by the transcription factor ETS proto-oncogene 1 (ETS1), is a pathogenic feature of primary sclerosing cholangitis (PSC). Furthermore, histone 3 lysine 27 is acetylated at senescence-associated loci.
Kang JH, Splinter PL, Trussoni CE, Pirius NE, Gores GJ, LaRusso NF, O'Hara SP.   +6 more
europepmc   +5 more sources

Mesangial cell expression of proto-oncogene Ets-1 during progression of mesangioproliferative glomerulonephritis [PDF]

Kidney International, 2004
Ets-1 is a transactivator of matrix-associated genes and key factor in neoangiogenesis. The expression of Ets-1 mRNA and protein was analyzed in healthy rat kidney and in a model for mesangioproliferative disease without and with inhibition of platelet-derived growth factor-B (PDGF-B) activity.Immunohistochemistry was performed using a specific ...
Ute Raffetseder, Nico Wernert, Tammo Ostendorf, Claudia van Roeyen, Thomas Rauen, Peter Behrens, Jürgen Floege, Peter R. Mertens   +7 more
exaly   +5 more sources

Expression of the ets-1 Proto-Oncogene in Human Colorectal Carcinoma [PDF]

Modern Pathology, 2001
The proto-oncogene, ets-1, is a transcription factor known to control the expression of a number of genes involved in extracellular matrix remodeling and has been postulated to play a role in cell migration and tumor invasion. To elucidate the involvement of ets-1 in human colorectal carcinomas, we examined 41 cases of colorectal adenoma and 122 cases ...
Toshiyuki Nakayama, Masahiro Ito, Akira Ohtsuru, Shinji Naito, Ichiro Sekine   +4 more
exaly   +6 more sources

A prognostic risk prediction model for gastric cancer based on the EFNA4 and ETS1 regulatory axis in tumor cells [PDF]

Scientific Reports
Gastric cancer (GC) is a major cause of cancer-related deaths worldwide, and is characterised by intricate molecular mechanisms. However, analysis of its molecular and clinical characteristics is complicated by its histological and etiological ...
Yixuan Chen, Ning Wang, Junkun Wang, Shupei Li, Wenchen Zhang, Wenjiang Deng, Jingjing Ye, Zhoujuan Yao, Hui Zhang, Fengsong Wang, Wenbin Wang   +10 more
doaj   +3 more sources

rSjP40 Inhibited the Activity of Collagen Type I Promoter via Ets-1 in HSCs

Frontiers in Cell and Developmental Biology, 2021
Liver fibrosis is a severe disease characterized by excessive deposition of extracellular matrix (ECM) components in the liver. Activated hepatic stellate cells (HSCs) are a major source of ECM and a key regulator of liver fibrosis. Collagen type I alpha
Jing Li, Jing Li, Jiali Zhang, Jiali Zhang, Bei Zhang, Liuting Chen, Guo Chen, Dandan Zhu, Jinling Chen, Lian Duan, Yinong Duan   +10 more
doaj   +2 more sources

Ets-1 Proto-Oncogene as a Potential Predictor for Poor Prognosis of Lung Adenocarcinoma

The Tohoku Journal of Experimental Medicine, 2007
The proto-oncogene Ets-1 is a transcription factor that is known to regulate certain matrix metalloproteinases and plasminogen activator, which have been associated with malignant behaviors in solid carcinomas. We hypothesized that Ets-1 expression is also associated with tumor progression and a worse prognosis in lung carcinoma patients.
Eiichiro Yamaguchi, Toshiyuki Nakayama, Atsushi Nanashima, Keitaro Matsumoto, Toru Yasutake, Ichiro Sekine, Takeshi Nagayasu   +6 more
exaly   +6 more sources

Elevated interleukin-17A levels despite reduced microRNA-326 gene expression in celiac disease patients under gluten-free diet

Romanian Journal of Internal Medicine, 2022
Introduction: The microRNA-326 (miR-326) gene, by targeting ETS Proto-Oncogene 1 (ETS1), regulates the differentiation and interleukin-17A production of T helper 17 (Th17) cells.
Nafari Maedeh, Asri Nastaran, Rostami-Nejad Mohammad, Forouzesh Flora, Ehsani-Ardakani Mohammad Javad, Jahani-Sherafat Somayeh, Rezaei-Tavirani Mostafa, Aghdaei Hamid Asadzadeh   +7 more
doaj   +2 more sources

Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma

Journal of Innate Immunity, 2020
Children exposed to common aeroallergens may develop asthma that progresses into adulthood. Inflammation regulated by T helper 2 (Th2) cells, a specific subpopulation of CD4+ T lymphocytes, is involved in asthmatic injury.
Tianyue  Wang, Qianlan Zhou, Yunxiao Shang   +2 more
doaj   +2 more sources