Results 11 to 20 of about 29,837,514 (156)

Circular RNA_0000326 promotes bladder cancer progression via microRNA-338-3p/ETS Proto-Oncogene 1/phosphoinositide-3 kinase/Akt pathway. [PDF]

Bioengineered, 2021
Circular RNAs (circRNAs) play a pivotal regulatory role in bladder cancer (BC) occurrence and progression. The expression level, role and mechanism of circ_0000326 in BC remain unknown.
Chen Y, Wang D, Shu T, Sun K, Zhao J, Wang M, Huang Y, Wang P, Zheng H, Cai Z, Yang Z.   +10 more
europepmc   +2 more sources

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2 [PDF]

, 1996
The Ras oncogene products regulate the expression of genes in transformed cells, and members of the Ets family of transcription factors have been implicated in this process.
Yang, Beom-Seok, Ostrowski, M C, Hauser, C A, Hauser, Craig A., Van Beveren, Charles, Maki, R A, Yang, B S, Henkel, G, Hume, D A, Ostrowski, Michael C., Colman, M S, Colman, Michael S., Van Beveren, C, Henkel, Gregory, Stacey, K J, Hume, David A., Maki, Richard A., Stacey, Katryn J.   +17 more
core   +1 more source

Erythropoietin Inhibits Hypoxia–Induced Epithelial-To-Mesenchymal Transition via Upregulation of miR-200b in HK-2 Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: Renal tubular epithelial-mesenchymal transition (EMT) is regarded as an important factor leading to renal interstitial fibrosis. Erythropoietin (EPO) has been reported to attenuate renal fibrosis. The mechanism underlying this protective
Jiuxu Bai, Xiao Xiao, Xiaoling Zhang, Hanmin Cui, Junfeng Hao, Jingming Han, Ning Cao   +6 more
doaj   +1 more source

Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells [PDF]

, 2009
Background Transplantation of vasculogenic progenitor cells (VPC) improves neovascularization after ischemia. However, patients with type 2 diabetes mellitus show a reduced VPC number and impaired functional activity. Previously, we demonstrated that p38
Aicher Alexandra, Chen Linping, Seeger Florian Hartmut, Altschmied Joachim, Haendeler Judith, Alexandra Aicher, Aicher, Alexandra, Judith Haendeler, Seeger, Florian Hartmut, Chen, Linping, Haendeler, Judith, Florian Hartmut Seeger, Linping Chen, Joachim Altschmied, Spyridopoulos Ioakim, Spyridopoulos, Ioakim, Altschmied, Joachim, Ioakim Spyridopoulos   +17 more
core   +2 more sources

Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice [PDF]

, 2000
The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating factor 1 (CSF-1)- and mitogen-activated protein kinase-independent manner in macrophages isolated from motheaten-viable (me-v) mice.
Forsthoefel, David, Ostrowski, M C, Hartman, M, Schaffner, A E, Smith, James L., Hume, D A, Smith, J L, Ostrowski, Michael C., Wei, G, Hofmeister, Joseph K., Hofmeister, J K, Schaffner, Alicia E., Wei, Guo, Hume, David A., Hartman, Matthew, Hartman, Matthew Hartman, Forsthoefel, D   +16 more
core   +1 more source

ETS-1 oncoprotein expression is decreased in aggressive papillary transitional cell carcinoma of the urinary bladder: An immunohistochemical study

African Journal of Urology, 2017
Introduction: ETS-1 proto-oncogene is a transcription factor that plays multiple roles in the process of oncogenesis and helps in the process of tumor invasion.
E.A. Ibrahim, M.R. Hassan, S.A. Sammour
doaj   +1 more source

Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma

Journal of Innate Immunity, 2020
Children exposed to common aeroallergens may develop asthma that progresses into adulthood. Inflammation regulated by T helper 2 (Th2) cells, a specific subpopulation of CD4+ T lymphocytes, is involved in asthmatic injury.
Tianyue  Wang, Qianlan Zhou, Yunxiao Shang   +2 more
doaj   +1 more source

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2 [PDF]

, 2015
Ets-2, like its closely related homologue Ets-1, is a member of the Ets family of DNA binding transcription factors. Both proteins are subject to multiple levels of regulation of their DNA binding and transactivation properties.
Gileadi, Opher, Cooper, Christopher D.O., Newman, Joseph A., Aitkenhead, Hazel   +3 more
core   +1 more source

LINC00704 contributes to the proliferation and accelerates the cell cycle of nasopharyngeal carcinoma cells via regulating ETS1/CDK6 axis

Kaohsiung Journal of Medical Sciences, 2022
This study is aimed at exploring the biological functions and related mechanism of long noncoding RNA 704 (LINC00704) in the proliferation and cell cycle progression of nasopharyngeal carcinoma (NPC) cells.
Yan Wang, Qi‐Yan Tan, Ying Shen, Chang‐Yu Liu, Tao Huang, De Huai, Jun Dai   +6 more
doaj   +1 more source

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition. [PDF]

, 2014
The Ets family of eukaryotic transcription factors is based around the conserved Ets DNA-binding domain. Although their DNA-binding selectivity is biochemically and structurally well characterized, structures of homodimeric and ternary complexes point to
Gileadi, Opher, Newman, JA, Cooper, CD, Joseph A Newman, Gileadi, O, Cooper, Christopher D.O., Christopher D O Cooper, Newman, Joseph A., Opher Gileadi   +8 more
core   +1 more source