Results 11 to 20 of about 116,033,210 (184)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer. [PDF]

Mol Oncol
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Yu M, Das P, Zhang X, Cheng X.
europepmc   +2 more sources

rSjP40 Inhibited the Activity of Collagen Type I Promoter via Ets-1 in HSCs

Frontiers in Cell and Developmental Biology, 2021
Liver fibrosis is a severe disease characterized by excessive deposition of extracellular matrix (ECM) components in the liver. Activated hepatic stellate cells (HSCs) are a major source of ECM and a key regulator of liver fibrosis. Collagen type I alpha
Jing Li, Jing Li, Jiali Zhang, Jiali Zhang, Bei Zhang, Liuting Chen, Guo Chen, Dandan Zhu, Jinling Chen, Lian Duan, Yinong Duan   +10 more
doaj   +1 more source

Proto-Oncogene Ets-1 and the Kidney [PDF]

Nephron, 2001
Most forms of advanced glomerular diseases, if not all, are characterized by abnormal turnover of extracellular matrix (ECM) proteins in glomeruli, resulting in structural alterations of glomerular basement membrane and mesangial matrix, usually leading to proteinuria. It is, therefore, important to elucidate the regulatory mechanisms of ECM metabolism
M S, Razzaque, T, Naito, T, Taguchi
openaire   +2 more sources

Expression of the Ets-1 Proto-Oncogene in Melanocytic Lesions [PDF]

Modern Pathology, 2003
Ets-1 oncoprotein is a transcription factor known to regulate the expression of numerous genes important in extracellular matrix remodeling and angiogenesis. Up-regulation of Ets-1 has been shown to be important in a variety of human malignancies and to correlate with prognosis.
Connie A, Keehn, Bruce R, Smoller, Michael B, Morgan   +2 more
openaire   +2 more sources

Bioinformatics network analyses of growth differentiation factor 11

Open Life Sciences, 2022
Growth differentiation factor 11 (GDF11) has been implicated in rejuvenating functions in age-related diseases. The molecular mechanisms connecting GDF11 with these anti-aging phenomena, including reverse age-related cardiac hypertrophy and vascular and ...
Zhang Feng, Yang Xia, Bao Zhijun
doaj   +1 more source

Elevated interleukin-17A levels despite reduced microRNA-326 gene expression in celiac disease patients under gluten-free diet

Romanian Journal of Internal Medicine, 2022
Introduction: The microRNA-326 (miR-326) gene, by targeting ETS Proto-Oncogene 1 (ETS1), regulates the differentiation and interleukin-17A production of T helper 17 (Th17) cells.
Nafari Maedeh, Asri Nastaran, Rostami-Nejad Mohammad, Forouzesh Flora, Ehsani-Ardakani Mohammad Javad, Jahani-Sherafat Somayeh, Rezaei-Tavirani Mostafa, Aghdaei Hamid Asadzadeh   +7 more
doaj   +1 more source

Hypoxia stimulates angiogenesis and a metabolic switch in human parathyroid adenoma cells

Endocrine Oncology, 2023
Hypoxia, a primary stimulus for angiogenesis, is important for tumour proliferation and survival. The effects of hypoxia on parathyroid tumour cells, which may also be important for parathyroid autotransplantation in patients, are, however, unknown.
K E Lines, M Stevenson, R Mihai, I V Grigorieva, O A Shariq, K U Gaynor, J Jeyabalan, M Javid, R V Thakker   +8 more
doaj   +1 more source

ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. [PDF]

J Biol Chem, 2017
Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory cholangiopathy (disease of the bile ducts) of unknown pathogenesis. We reported that cholangiocyte senescence features prominently in PSC and that neuroblastoma RAS viral oncogene homolog (NRAS) is activated in PSC cholangiocytes. Additionally, persistent microbial insult (e.g.
O'Hara SP, Splinter PL, Trussoni CE, Pisarello MJ, Loarca L, Splinter NS, Schutte BF, LaRusso NF.   +7 more
europepmc   +4 more sources

Inversion of a chicken ets-1 proto-oncogene segment in avian leukemia virus E26 [PDF]

Journal of Virology, 1993
The segment of the avian leukemia virus E26 genome near the termination of the p135gag-myb-ets open reading frame contains an inversion of the chicken ets-1 sequence. The inversion contains at least 41 bp and may be as large as 46 bp. This results in the replacement of 13 amino acids of chicken ets-1, with 16 amino acids derived from reverse complement
J A, Lautenberger, T S, Papas
openaire   +2 more sources

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2 [PDF]

, 1996
The Ras oncogene products regulate the expression of genes in transformed cells, and members of the Ets family of transcription factors have been implicated in this process.
Yang, Beom-Seok, Ostrowski, M C, Hauser, C A, Hauser, Craig A., Van Beveren, Charles, Maki, R A, Yang, B S, Henkel, G, Hume, D A, Ostrowski, Michael C., Colman, M S, Colman, Michael S., Van Beveren, C, Henkel, Gregory, Stacey, K J, Hume, David A., Maki, Richard A., Stacey, Katryn J.   +17 more
core   +1 more source