Results 141 to 150 of about 152,993 (306)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The IFMIF-DONES Irradiation Modules

Nuclear Fusion
The IFMIF-DONES Irradiation Modules consist of a set of systems designed to be tested in the IFMIF-DONES facility and which are thought to produce, in the future, an extensive, qualified and unique set of fusion-like irradiated experimental data ...
F. Arbeiter, U. Wiącek, B. Brañas, S. Gordeev, A. Kupferschmitt, Y. Qiu, A. Serikov, G. Zhou, J. Kotula, F. Arranz, F. Mota, M.I. Ortiz, D. Rapisarda, P. Araya, S. Becerril, T. Dézsi, J. Castellanos, A. Ibarra, the Eurofusion WPENS Team   +18 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Strain mapping and defects inspection of divertor targets by Bragg edge neutron imaging and neutron tomography

Nuclear Fusion
The divertor target of a nuclear fusion reactor is a key in-vessel component with critical operational functions to exhaust particles at associated thermal power.
Triestino Minniti, Roberto Coppola, Winfried Kockelmann, Anton S. Tremsin, Selanna Roccella, Henri Greuner, Jeong-Ha You   +6 more
doaj   +1 more source

EU-DEMO vacuum vessel port closure plate fastening developments

Fusion Engineering and Design
The EU-DEMO project, which has been in the Concept Design phase since 2021, is already focusing on the integration of the main system components but is also analysing variants to simplify this process. One of these is the fastening and sealing of vacuum vessel closures, known as port closure plates, in order to simplify the execution of the work with ...
Haertl, T., Bachmann, C., Janeschitz, G., Steinbacher, T., Vizvary, Z.   +4 more
openaire   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Runaway electron beam formation, vertical motion, termination and wall loads in EU-DEMO

Nuclear Fusion
Runaway electron (RE) loads onto material structures are a major concern for future large tokamaks due to the efficient avalanching at high plasma currents.
F. Vannini, V. Bandaru, H. Bergström, N. Schwarz, F.J. Artola, M. Hoelzl, G. Pautasso, E. Nardon, F. Maviglia, M.L. Richiusa, E. Emanuelli, the JOREK Team   +11 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source