Results 181 to 190 of about 822 (209)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Interactive digital twins enabling responsible extended reality applications. [PDF]

Sci Rep
Antoun M, Elhajj IH, Sayour M, Papadopoulos PK, Zarpalas D, Rizk A, Islam AT, Huerta I, Toledo L, Arvanitis G, Moustakas K, Jevtić A, Agustí I, Vona F, Voigt-Antons JN, Warsinke M, Bailer W, Thallinger G, Howkins B, Poder I, Ruess M, Asmar D.   +21 more
europepmc   +1 more source

Assessment of airborne bacteria from a public health institution in Mexico City. [PDF]

PLOS Glob Public Health
Calderón-Ezquerro MC, Ponce de León A A, Brunner-Mendoza C, Guerrero-Guerra C C, Sanchez-Flores A, Salinas-Peralta I, López Jacome LE, Colín Castro C CA, Martínez Zavaleta MG.   +8 more
europepmc   +1 more source

Relationship troubles at the mitochondrial level and what it might mean for human disease. [PDF]

Open Biol
James R.
europepmc   +1 more source

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How post-merger integration duration affects merger outcomes

Journal of Business and Industrial Marketing, 2021
Wesley J Johnston
exaly