gammaH2AX foci form preferentially in euchromatin after ionising-radiation.
PLoS ONE, 2007 BackgroundThe histone variant histone H2A.X comprises up to 25% of the H2A complement in mammalian cells. It is rapidly phosphorylated following exposure of cells to double-strand break (DSB) inducing agents such as ionising radiation.
Ian G Cowell +5 more
doaj +2 more sources
Nucleosome dynamics render heterochromatin accessible in living human cells [PDF]
Nature CommunicationsThe eukaryotic genome is packaged into chromatin, which is composed of a nucleosomal filament that coils up to form more compact structures.
Hemant K. Prajapati +3 more
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Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. [PDF]
PLoS Pathogens, 2013 The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV).
Zsolt Toth +6 more
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Author Correction: Transcription organizes euchromatin via microphase separation [PDF]
Nature Communications, 2021 Lennart Hilbert +8 more
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Fiber-Like Organization as a Basic Principle for Euchromatin Higher-Order Structure
Frontiers in Cell and Developmental Biology, 2022 A detailed understanding of the principles of the structural organization of genetic material is of great importance for elucidating the mechanisms of differential regulation of genes in development.
Amir N. Zakirov +13 more
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Transcription organizes euchromatin via microphase separation
Nature Communications, 2021 How euchromatin organisation and transcription are related is unclear. Here, the authors observe the dynamics of euchromatin organization showing that accumulating RNA recruits RNA-binding proteins that together with transcribed euchromatin separate from
Lennart Hilbert +8 more
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The Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways
Frontiers in Cell and Developmental Biology, 2022 DNA double-strand breaks (DSBs), the most deleterious DNA lesions, are primarily repaired by two pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ), the choice of which is largely dependent on cell cycle phase and the ...
Zulong Chen, Jessica K. Tyler
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Current Analytical Strategies in Studying Chromatin-Associated-Proteome (Chromatome)
Molecules, 2021 Chromatin is a dynamic structure comprising of DNA and proteins. Its unique nature not only help to pack the DNA tightly within the cell but also is pivotal in regulating gene expression DNA replication.
Niamat Khan, Sidra Shahid, Abdul R. Asif
doaj +1 more source
Chemotherapy (Etoposide)-Induced Intermingling of Heterochromatin and Euchromatin Compartments in Senescent PA-1 Embryonal Carcinoma Cells [PDF]
Cancers (Basel)Bayer M +9 more
europepmc +3 more sources
Life, 2022 Nucleosome positioning plays an important role in crucial biological processes such as replication, transcription, and gene regulation. It has been widely used to predict the genome’s function and chromatin organisation.
Sujeet Kumar Mishra +5 more
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