Transcription organizes euchromatin via microphase separation [PDF]
Nature Communications, 2021 How euchromatin organisation and transcription are related is unclear. Here, the authors observe the dynamics of euchromatin organization showing that accumulating RNA recruits RNA-binding proteins that together with transcribed euchromatin separate from
Lennart Hilbert +8 more
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Nucleosome dynamics render heterochromatin accessible in living human cells [PDF]
Nature CommunicationsThe eukaryotic genome is packaged into chromatin, which is composed of a nucleosomal filament that coils up to form more compact structures.
Hemant K. Prajapati +3 more
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The SUV39 Family of H3K9 Methyltransferases in Skeletal Muscle Stem Cells [PDF]
FASEB BioAdvances, Volume 7, Issue 6, June 2025.The SUV39 family members are well known for methylating the Lysine 9 of the histone H3 (H3K9) in order to compact the chromatin and contributing to gene repression. We describe their active role in proliferating and differentiating muscle stem cells, how they prevent from inflammation and fibrosis during muscle regeneration and the future avenues ...
Pauline Garcia +2 more
wiley +2 more sources
Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair [PDF]
Nature CommunicationsDNA double-strand breaks (DSBs) must be properly repaired within diverse chromatin domains to maintain genome stability. Whereas euchromatin has an open structure and is associated with transcription, facultative heterochromatin is essential to silence ...
Marieke R. Wensveen +7 more
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Chromatin phase separation and nuclear shape fluctuations are correlated in a polymer model of the nucleus [PDF]
NucleusAbnormal cell nuclear shapes are hallmarks of diseases, including progeria, muscular dystrophy, and many cancers. Experiments have shown that disruption of heterochromatin and increases in euchromatin lead to nuclear deformations, such as blebs and ...
Ali Goktug Attar +3 more
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Widespread chromatin context-dependencies of DNA double-strand break repair proteins [PDF]
Nature CommunicationsDNA double-strand breaks are repaired by multiple pathways, including non-homologous end-joining (NHEJ) and microhomology-mediated end-joining (MMEJ).
Xabier Vergara +10 more
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Fiber-Like Organization as a Basic Principle for Euchromatin Higher-Order Structure
Frontiers in Cell and Developmental Biology, 2022 A detailed understanding of the principles of the structural organization of genetic material is of great importance for elucidating the mechanisms of differential regulation of genes in development.
Amir N. Zakirov +13 more
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The Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways
Frontiers in Cell and Developmental Biology, 2022 DNA double-strand breaks (DSBs), the most deleterious DNA lesions, are primarily repaired by two pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ), the choice of which is largely dependent on cell cycle phase and the ...
Zulong Chen, Jessica K. Tyler
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A Liquid State Perspective on Dynamics of Chromatin Compartments
Frontiers in Molecular Biosciences, 2022 The interior of the eukaryotic cell nucleus has a crowded and heterogeneous environment packed with chromatin polymers, regulatory proteins, and RNA molecules.
Rabia Laghmach +2 more
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Life, 2022 Nucleosome positioning plays an important role in crucial biological processes such as replication, transcription, and gene regulation. It has been widely used to predict the genome’s function and chromatin organisation.
Sujeet Kumar Mishra +5 more
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