Transcription organizes euchromatin via microphase separation [PDF]
Nature Communications, 2021 How euchromatin organisation and transcription are related is unclear. Here, the authors observe the dynamics of euchromatin organization showing that accumulating RNA recruits RNA-binding proteins that together with transcribed euchromatin separate from
Lennart Hilbert +8 more
doaj +2 more sources
Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair [PDF]
Nature CommunicationsDNA double-strand breaks (DSBs) must be properly repaired within diverse chromatin domains to maintain genome stability. Whereas euchromatin has an open structure and is associated with transcription, facultative heterochromatin is essential to silence ...
Marieke R. Wensveen +7 more
doaj +2 more sources
Chromatin phase separation and nuclear shape fluctuations are correlated in a polymer model of the nucleus [PDF]
NucleusAbnormal cell nuclear shapes are hallmarks of diseases, including progeria, muscular dystrophy, and many cancers. Experiments have shown that disruption of heterochromatin and increases in euchromatin lead to nuclear deformations, such as blebs and ...
Ali Goktug Attar +3 more
doaj +2 more sources
Widespread chromatin context-dependencies of DNA double-strand break repair proteins [PDF]
Nature CommunicationsDNA double-strand breaks are repaired by multiple pathways, including non-homologous end-joining (NHEJ) and microhomology-mediated end-joining (MMEJ).
Xabier Vergara +10 more
doaj +2 more sources
Single-cell 3D genome structure reveals distinct human pluripotent states [PDF]
Genome BiologyBackground Pluripotent states of embryonic stem cells (ESCs) with distinct transcriptional profiles affect ESC differentiative capacity and therapeutic potential.
Niannian Li +7 more
doaj +2 more sources
Fiber-Like Organization as a Basic Principle for Euchromatin Higher-Order Structure
Frontiers in Cell and Developmental Biology, 2022 A detailed understanding of the principles of the structural organization of genetic material is of great importance for elucidating the mechanisms of differential regulation of genes in development.
Amir N. Zakirov +13 more
doaj +1 more source
The Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways
Frontiers in Cell and Developmental Biology, 2022 DNA double-strand breaks (DSBs), the most deleterious DNA lesions, are primarily repaired by two pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ), the choice of which is largely dependent on cell cycle phase and the ...
Zulong Chen, Jessica K. Tyler
doaj +1 more source
A Liquid State Perspective on Dynamics of Chromatin Compartments
Frontiers in Molecular Biosciences, 2022 The interior of the eukaryotic cell nucleus has a crowded and heterogeneous environment packed with chromatin polymers, regulatory proteins, and RNA molecules.
Rabia Laghmach +2 more
doaj +1 more source
Life, 2022 Nucleosome positioning plays an important role in crucial biological processes such as replication, transcription, and gene regulation. It has been widely used to predict the genome’s function and chromatin organisation.
Sujeet Kumar Mishra +5 more
doaj +1 more source
Current Analytical Strategies in Studying Chromatin-Associated-Proteome (Chromatome)
Molecules, 2021 Chromatin is a dynamic structure comprising of DNA and proteins. Its unique nature not only help to pack the DNA tightly within the cell but also is pivotal in regulating gene expression DNA replication.
Niamat Khan, Sidra Shahid, Abdul R. Asif
doaj +1 more source