Results 121 to 130 of about 387,698 (305)

The landscape of transcription errors in eukaryotic cells [PDF]

, 2017
This paper provides the first comprehensive analysis of the fidelity of transcription in eukaryotic cells.
Clark Fritsch, Marc Vermulst, Annie Li, Hossein Fazelinia, Weiyi Li, Zach Smith, Larry Singh, Michael Lynch, Steven Seeholzer, Jean-Francois Gout, Ding Hua, Kelley Thomas, Suraiya Haroon   +12 more
core   +1 more source

Construction of A Eukaryotic Expression Vector Carrying the iNOS Gene and Its Effect on A549 Lung Cancer Cells

Chinese Journal of Lung Cancer, 2012
Background and objective The iNOS gene is associated with NO-mediated antitumor effects. The aims of this study are to construct a eukaryotic expression plasmid that carries the iNOS gene and to detect the expression levels and antitumor effects of the ...
Sujuan YE, Weihan YANG, Yu WANG, Wenjing OU, Qingping MA, Wen ZHU   +5 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Applications of Recombinant Dna Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part B: Eukaryotic Gene Transcription and Post-Transcripional Rna Processing

Canadian Journal of Gastroenterology, 2000
The transcription of DNA into RNA is the primary level at which gene expression is controlled in eukaryotic cells. Eukaryotic gene transcription  involves several different RNA polymerases that interact with a host of transcription factors to initiate ...
Gary E Wild, Patrizia Papalia, Mark J Ropeleski, Julio Faria, Alan BR Thomson   +4 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Life at acidic pH imposes an increased energetic cost for a eukaryotic acidophile [PDF]

, 2005
Organisms growing in acidic environments, pH <3, would be expected to possess fundamentally different molecular structures and physiological controls in comparison with similar species restricted to neutral pH.
Jung, Sung-Kwon, Zettler, Erik, Messerli, Mark A., Sogin, Mitchell L., Amaral-Zettler, Linda A., Smith, Peter J.S.   +5 more
core  

Bacteriophage Interactions With Epithelial Cells: Therapeutic Implications

Frontiers in Microbiology, 2021
Andrzej Górski, Andrzej Górski, Andrzej Górski, Jan Borysowski, Ryszard Miȩdzybrodzki, Ryszard Miȩdzybrodzki, Ryszard Miȩdzybrodzki   +6 more
doaj   +1 more source

Prokaryotic microvesicles Ortholog of eukaryotic extracellular vesicles in biomedical fields

Cell Communication and Signaling
Every single cell can communicate with other cells in a paracrine manner via the production of nano-sized extracellular vesicles. This phenomenon is conserved between prokaryotic and eukaryotic cells.
Halimeh Mobarak, Farzin Javid, Maryam Taghavi Narmi, Narges Mardi, Fatemeh Sadeghsoltani, Parisa Khanicheragh, Samaneh Narimani, Mahdi Mahdipour, Emel Sokullu, Ferzane Valioglu, Reza Rahbarghazi   +10 more
doaj   +1 more source

Direct Synthesis of High‐Valence Protein@UiO‐66 Composites: Linking Crystallization Pathways to Protein Encapsulation

Advanced Materials, EarlyView.
This work reports a direct, biocompatible method to synthesize UiO‐66, enabling one‐step encapsulation of proteins without compromising crystallinity or activity. Using advanced in situ and ex situ techniques, the study reveals that proteins integrate concurrently with MOF growth, forming crystalline protein@UiO‐66 nanoparticles, and provide insight ...
Jesús Cases Díaz, Jana Glatz, Elisa Merced Olivas, Ramon Pons, Joseph P. Patterson, Mónica Giménez‐Marqués   +5 more
wiley   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source