Results 171 to 180 of about 614,303 (330)

EUKARYOTIC CELL [PDF]

open access: yesEukaryotic Cell, 2006
openaire   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

open access: yesAdvanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li   +13 more
wiley   +1 more source

The <i>Shigella flexneri</i> virulence factor apyrase is released inside eukaryotic cells to hijack host cell fate. [PDF]

open access: yesMicrobiol Spectr, 2023
Perruzza L   +10 more
europepmc   +1 more source

Type II Alveolar Epithelial Cells Promote Sepsis‐Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release

open access: yesAdvanced Science, EarlyView.
The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...
Chengxi Liu   +17 more
wiley   +1 more source

Plasma Membrane Wounding and Repair Assays for Eukaryotic Cells. [PDF]

open access: yesBio Protoc, 2022
Sønder SL   +4 more
europepmc   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

open access: yesAdvanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu   +14 more
wiley   +1 more source

Influence of Lipid Composition of Cationic Liposomes 2X3-DOPE on mRNA Delivery into Eukaryotic Cells. [PDF]

open access: yesPharmaceutics, 2022
Vysochinskaya V   +14 more
europepmc   +1 more source

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