Results 261 to 270 of about 604,841 (328)

Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation

open access: yesAdvanced Science, EarlyView.
Spatial transcriptomic analysis of Anaplastic thyroid carcinoma (ATC)‐differentiated thyroid carcinoma (DTC) coexisting tumors reveals that coexisting DTC regions with ATC‐like genomic alterations undergo sequential transcriptomic reprogramming and immune microenvironment remodeling, ultimately evolving into a full ATC pathological phenotype.
Kang Ning   +19 more
wiley   +1 more source

Intimin from enteropathogenic Escherichia coli mediates remodelling of the eukaryotic cell surface

open access: bronze, 2000
Alan D. Phillips   +4 more
openalex   +1 more source

H2S Is a Potential Universal Reducing Agent for Prx6‐Type Peroxiredoxins

open access: yesAdvanced Science, EarlyView.
We report the identification of H2S as reducing agent for Prx6‐type peroxiredoxins. In contrast to common physiological reducing agents of other peroxiredoxins, HS− is small enough to access the active site of oxidized Prx6‐type enzymes in the fully‐folded protein conformation.
Lukas Lang   +3 more
wiley   +1 more source

H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A‐Driven EP300 Expression

open access: yesAdvanced Science, EarlyView.
An et al. reveal H3K27ac elevation is essential for establishing and maintaining human naive pluripotency; its inhibition disrupts this state while enhancement promotes it. METTL3‐mediated m6A modification indirectly controls H3K27ac by suppressing EP300 expression. Reduced EP300 lowers H3K27ac, impeding naive pluripotency.
Chenrui An   +13 more
wiley   +1 more source

Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function

open access: yesAdvanced Science, EarlyView.
Nestin localizes to the mitochondrial IMS through its MTS and the TOM20 import machinery. Within the mitochondria, Nestin interacts with Mic60 via its C‐terminal Tail3 domain. Loss of mitochondrial Nestin disrupts cristae architecture, leading to mitochondrial swelling, bioenergetic dysfunction, and ultimately the senescence of hMSCs.
Hainan Chen   +14 more
wiley   +1 more source

Correction: Transcription factor clusters regulate genes in eukaryotic cells

open access: yeseLife, 2019
Adam JM Wollman   +5 more
doaj   +1 more source

Curli Fibers Mediate Internalization of Escherichia coli by Eukaryotic Cells

open access: green, 2001
Uri Gophna   +5 more
openalex   +1 more source

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