Results 201 to 210 of about 206,173 (282)

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

NQO1‐Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell‐Targeted Migrastatic

Small, EarlyView.
The design, synthesis, biochemical, and cell biological evaluation of the NQO1‐targeted prodrug BQTML‐CB is reported. BQTML‐CB selectively releases cytochalasin B upon activation by the quinone‐oxidoreductase NQO1 associated with invasiveness of cancer cells, representing a novel approach to improve cancer selectivity and reduce immunosuppressive ...
Mervic D. Kagho, Katharina Schmidt, Christopher Lambert, Lili Jia, Vignesh Venkatakrishnan, Luisa Mehr, Johan Bylund, Klemens Rottner, Marc Stadler, Theresia E. B. Stradal, Philipp Klahn   +10 more
wiley   +1 more source

Molecular characterisation of Toxoplasma gondii Mre11 reveals unique structural features and potential as a therapeutic target. [PDF]

Sci Rep
Ruiz DM, Turowski VR, Sullivan WJ, Angel SO.   +3 more
europepmc   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Quadrupia provides a comprehensive catalog of G-quadruplexes across genomes from the tree of life. [PDF]

Genome Res
Chantzi N, Nayak A, Baltoumas FA, Aplakidou E, Liew SW, Galuh JE, Patsakis M, Montgomery A, Moeckel C, Mouratidis I, Sazed SA, Guiblet W, Karmiris-Obratański P, Wang G, Zaravinos A, Vasquez KM, Kwok CK, Pavlopoulos GA, Georgakopoulos-Soares I.   +18 more
europepmc   +1 more source

Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome

Small, EarlyView.
Biomimetic nanocarriers based on liposomes and Myxobacteria outer‐membrane vesicles (OMVs) are effective antibiotic delivery systems. Hybrids have a higher drug loading and can target intracellular pathogens, while OMVs evade immune clearance. Biomimetic nanoantibiotics effectively eliminate the biofilms of Gram‐negative bacteria. Besides, Myxobacteria
Leila Pourtalebi Jahromi, Benedikt Kronast, Jennifer Munkert, Lorenzo Sana, Marcus Koch, Heike Danzer, Sirka Dormeyer, Shuhan Jiang, Fabian Herrmann, Matthias Weiler, Anna Kashkanova, Vahid Sandoghdar, Mario M. Zaiss, Gregor Fuhrmann   +13 more
wiley   +1 more source

Emerging roles of RNA:DNA hybrid regulation by mammalian ribonuclease H2 in replication stress and cancer. [PDF]

J Cell Sci
Wilkins RJ, Petermann E.
europepmc   +1 more source

Multiwalled Carbon Nanotubes as Physical Drivers of Chromosome Instability and Inflammatory Responses

Small Structures, EarlyView.
This article highlights the fibrous morphology of multiwalled carbon nanotubes as a key factor in their genotoxicity. Fibers physically interfere in cell division, generating binucleated cells and micronuclei, both of which are precursors of carcinogenesis.
Núria Pulido‐Artola, Joan Repullés, Marina Rodriguez‐Muñoz, Teresa Anglada, Anna Genescà   +4 more
wiley   +1 more source

Mechanistic coupling of enzymatic activities at the replisome. [PDF]

J Biol Chem
Welikala MU, Butterworth LJ, Beragama Arachchi RY, Trakselis MA.   +3 more
europepmc   +1 more source

Quality control in the initiation of eukaryotic DNA replication. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2011
Diffley JF.
europepmc   +1 more source