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Origins of DNA replication in eukaryotes
Molecular Cell, 2023Errors occurring during DNA replication can result in inaccurate replication, incomplete replication, or re-replication, resulting in genome instability that can lead to diseases such as cancer or disorders such as autism. A great deal of progress has been made toward understanding the entire process of DNA replication in eukaryotes, including the ...
Yixin Hu, Bruce Stillman
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The Initiation of Eukaryotic DNA Replication
Annual Review of Biochemistry, 2022DNA replication in eukaryotic cells initiates from large numbers of sites called replication origins. Initiation of replication from these origins must be tightly controlled to ensure the entire genome is precisely duplicated in each cell cycle. This is accomplished through the regulation of the first two steps in replication: loading and activation ...
Alessandro, Costa, John F X, Diffley
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Current Opinion in Cell Biology, 1994
The past year has seen the genetic characterization of a human replication origin as well as the identification and characterization of some key components of replication initiation complexes in budding yeast. These results should provide important information for determining how the initial events in DNA replication are regulated during the eukaryotic
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The past year has seen the genetic characterization of a human replication origin as well as the identification and characterization of some key components of replication initiation complexes in budding yeast. These results should provide important information for determining how the initial events in DNA replication are regulated during the eukaryotic
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DNA Replication in Eukaryotic Cells
Annual Review of Biochemistry, 2002▪ Abstract The maintenance of the eukaryotic genome requires precisely coordinated replication of the entire genome each time a cell divides. To achieve this coordination, eukaryotic cells use an ordered series of steps to form several key protein assemblies at origins of replication.
Stephen P, Bell, Anindya, Dutta
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Eukaryotic Replicative DNA Polymerases
2013DNA replication is a dynamic process that requires the precise coordination of numerous cellular proteins. At the core of replication in eukaryotic cells are three DNA polymerases, Pol α, Pol δ, and Pol e, which function cooperatively to ensure efficient and high-fidelity genome replication. These enzymes are members of the B family of DNA polymerases,
Erin Walsh, Kristin A. Eckert
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1996
Abstract A cell's ability to control replication of its DNA is fundamental to its normal development or transformation into a cancerous state. DNA replication is also a crucial step in the cell cycle, and recent improvements in our understanding of cell cycle control have promoted a fresh surge of interest in the subject.
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Abstract A cell's ability to control replication of its DNA is fundamental to its normal development or transformation into a cancerous state. DNA replication is also a crucial step in the cell cycle, and recent improvements in our understanding of cell cycle control have promoted a fresh surge of interest in the subject.
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Some Aspects of Eukaryotic DNA Replication
Annual Review of Biochemistry, 1978PERSPECTIVES AND SUMMARy 277 PROTEINS OF DNA REPLICATION 279 DNA REPLICATION UNIT (RU): SIZE AND ORGANIZATION 282 RATE OF DNA SYNTHESIS 284 ORIGIN AND TERMINUS OF REPLICATION UNITS ....... 285 INTERMEDIATES OF DNA REPLICATION ...... ... .... 287 STUDIES WITH INHIBITORS OF DNA SYNTHESIS 289 RNA IN DNA REPLICATION 291 INITIATION OF DNA
R Sheinin, J Humbert, R E Pearlman
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European Journal of Biochemistry, 1990
A complex network of interacting proteins and enzymes is required for DNA replication. Much of our present understanding is derived from studies of the bacterium Escherichia coli and its bacteriophages T4 and T7. These results served as a guideline for the search and the purification of analogous proteins in eukaryotes.
P, Thömmes, U, Hübscher
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A complex network of interacting proteins and enzymes is required for DNA replication. Much of our present understanding is derived from studies of the bacterium Escherichia coli and its bacteriophages T4 and T7. These results served as a guideline for the search and the purification of analogous proteins in eukaryotes.
P, Thömmes, U, Hübscher
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Review Eukaryotic DNA Replication
1990A complex network of interacting proteins and enzymes is required for DNA replication. Much of our present understanding is derived from studies of the bacterium Escherichia coli and its bacteriophages T4 and T7. These results served as a guideline for the search and the purification of analogous proteins in eukaryotes.
Pia Thömmes, Ulrich Hübscher
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Early events in eukaryotic DNA replication
Trends in Cell Biology, 1992Eukaryotic DNA replication is a tightly regulated process that occurs during a discrete period of the cell cycle known as S phase. Recent work in two different systems has identified key participants in this process and characterized many of the protein-protein interactions required for the establishment of functional replication complexes.
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