Results 101 to 110 of about 27,996,561 (298)

EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1) [PDF]

, 2012
Review on EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1), with data on DNA, on the protein encoded, and where the gene is ...
Clemens, M, Elia, A, Coldwell, M
core   +1 more source

Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress

iScience, 2019
Summary: The cellular stress response triggers a cascade of events leading to transcriptional reprogramming and a transient inhibition of global protein synthesis, which is thought to be mediated by phosphorylation of eukaryotic initiation factor-2α ...
Marisa Sanchez, Yingying Lin, Chih-Cheng Yang, Philip McQuary, Alexandre Rosa Campos, Pedro Aza Blanc, Dieter A. Wolf   +6 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1) [PDF]

, 2009
Review on EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1), with data on DNA, on the protein encoded, and where the gene is ...
Clemens, M, M Clemens (16061543), M Clemens, Coldwell, M, M Coldwell, M Coldwell (16061546)   +5 more
core   +1 more source

Investigation of the effects of different mTOR inhibitors on protein synthesis

, 2011
The mammalian target of rapamycin (mTOR), which controls diverse cellular processes, is regulated by the integration of many signals. Rapamycin strongly inhibits the proliferation of many cancer cell lines and there is a high level of interest in its ...
Huo, Yilin
core   +1 more source

eIF2α phosphorylation-ATF4 axis-mediated transcriptional reprogramming mitigates mitochondrial impairment during ER stress

Molecules and Cells
: Eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, which regulates all 3 unfolded protein response pathways, helps maintain cellular homeostasis and overcome endoplasmic reticulum (ER) stress through transcriptional and translational ...
Hien Thi Le, Jiyoung Yu, Hee Sung Ahn, Mi-Jeong Kim, In Gyeong Chae, Hyun-Nam Cho, Juhee Kim, Hye-Kyung Park, Hyuk Nam Kwon, Han-Jung Chae, Byoung Heon Kang, Jeong Kon Seo, Kyunggon Kim, Sung Hoon Back   +13 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

EIF3F (eukaryotic translation initiation factor 3, subunit F) [PDF]

, 2010
Review on EIF3F (eukaryotic translation initiation factor 3, subunit F), with data on DNA, on the protein encoded, and where the gene is ...
J Shi, MA Nelson, Nelson, MA, Shi, J
core   +1 more source

Mitochondrial Dysfunction and Stress Responses in Alzheimer’s Disease

Biology, 2019
Alzheimer’s disease (AD) patients display widespread mitochondrial defects. Brain hypometabolism occurs alongside mitochondrial defects, and correlates well with cognitive decline.
Ian Weidling, Russell H. Swerdlow
doaj   +1 more source

Hepatitis E Virus Protease Inhibits the Activity of Eukaryotic Initiation Factor 2-Alpha Kinase 4 and Promotes Virus Survival. [PDF]

J Virol, 2023
Kumar A, Subramani C, Raj S, Ranjith-Kumar CT, Surjit M.   +4 more
europepmc   +1 more source