Results 11 to 20 of about 119,956 (261)

Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. [PDF]

Adv Nutr, 2012
Regulation of mRNA translation is a rapid and effective means to couple changes in the cellular environment with global rates of protein synthesis. In response to stresses, such as nutrient deprivation and accumulation of misfolded proteins in the endoplasmic reticulum, phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α~P ...
Baird TD, Wek RC.
europepmc   +4 more sources

Nitric oxide: a regulator of eukaryotic initiation factor 2 kinases. [PDF]

Free Radic Biol Med, 2011
Generation of nitric oxide (NO(•)) can upstream induce and downstream mediate the kinases that phosphorylate the α subunit of eukaryotic initiation factor 2 (eIF2α), which plays a critical role in regulating gene expression. There are four known eIF2α kinases (EIF2AKs), and NO(•) affects each one uniquely. Whereas NO(•) directly activates EIF2AK1 (HRI),
Tong L, Heim RA, Wu S.
europepmc   +4 more sources

Stepwise assembly of the eukaryotic translation initiation factor 2 complex [PDF]

Journal of Biological Chemistry, 2022
The eukaryotic translation initiation factor 2 (eIF2) has key functions in the initiation step of protein synthesis. eIF2 guides the initiator tRNA to the ribosome, participates in scanning of the mRNA molecule, supports selection of the start codon, and modulates the translation of mRNAs in response to stress.
Vanselow, Sven, Neumann-Arnold, Lea, Wojciech-Moock, Franziska, Seufert, Wolfgang   +3 more
openaire   +2 more sources

Eukaryotic protein synthesis initiation factor 2 [PDF]

European Journal of Biochemistry, 1991
Polyproanthocyanidin (PPA), a phenolic polymer isolated from the plant Alhagi kirgisorum S. was found to interact strongly with eukaryotic initiation factor 2 (eIF‐2), thereby inhibiting reactions involving this protein. When added to a rabbit reticulocyte lysate system, PPA blocks in vitro translation and it appears to selectively bind and precipitate
W, Kudlicki, W D, Picking, G, Kramer, B, Hardesty, S K, Smailov, B G, Mukhamedzhanov, A V, Lee, B K, Iskakov   +7 more
openaire   +2 more sources

Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2 [PDF]

Genetics, 2001
Abstract Eukaryotic translation initiation factor 2 (eIF2) is a G protein heterotrimer required for GTP-dependent delivery of initiator tRNA to the ribosome. eIF2B, the nucleotide exchange factor for eIF2, is a heteropentamer that, in yeast, is encoded by four essential genes and one nonessential gene.
F L, Erickson, J, Nika, S, Rippel, E M, Hannig   +3 more
openaire   +2 more sources

Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria. [PDF]

PLoS ONE, 2018
The identification of inhibitors of eukaryotic protein biosynthesis, which are targeting single translation factors, is highly demanded. Here we report on a small molecule inhibitor, gephyronic acid, isolated from the myxobacterium Archangium gephyra ...
Yazh Muthukumar, Johanna Münkemer, Daniel Mathieu, Christian Richter, Harald Schwalbe, Heinrich Steinmetz, Wolfgang Kessler, Joachim Reichelt, Ulrike Beutling, Ronald Frank, Konrad Büssow, Joop van den Heuvel, Mark Brönstrup, Richard E Taylor, Sabine Laschat, Florenz Sasse   +15 more
doaj   +1 more source

Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E

Molecules, 2016
Preparations of Deguelia duckeana, known in Brazil as timbó, are used by indigenous people to kill fish. Reinvestigation of its extracts resulted in the isolation and identification of 11 known flavonoids identified as 3,5,4’-trimethoxy-4-prenylstilbene (
Lorena M. C. Cursino, Nerilson M. Lima, Renato Murillo, Cecilia V. Nunez, Irmgard Merfort, Matjaz Humar   +5 more
doaj   +1 more source

Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling

eLife, 2016
Internal ribosome entry sites (IRESs) are important RNA-based translation initiation signals, critical for infection by many pathogenic viruses. The hepatitis C virus (HCV) IRES is the prototype for the type 3 IRESs and is also invaluable for exploring ...
Zane A Jaafar, Akihiro Oguro, Yoshikazu Nakamura, Jeffrey S Kieft   +3 more
doaj   +1 more source

Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed −1 ribosomal frameshifting

Cell Reports, 2023
Summary: Many positive-strand RNA viruses, including all known coronaviruses, employ programmed −1 ribosomal frameshifting (−1 PRF) to regulate the translation of polycistronic viral RNAs.
Lian-Huan Wei, Yu Sun, Junjie U. Guo
doaj   +1 more source

Upregulation of a novel eukaryotic translation initiation factor 5A (eIF5A) in dengue 2 virus-infected mosquito cells

Virology Journal, 2010
Background Dengue virus, a mosquito-borne flavivirus, is the etiological agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. It generally induces apoptosis in mammalian cells, but frequently results in persistent infection in ...
Shih Yu-Tzu, Yang Chao-Fu, Chen Wei-June
doaj   +1 more source