Results 21 to 30 of about 27,996,561 (298)

Translation initiation factor eIF3 promotes programmed stop codon readthrough. [PDF]

, 2015
Programmed stop codon readthrough is a post-transcription regulatory mechanism specifically increasing proteome diversity by creating a pool of C-terminally extended proteins.
von der Haar, Tobias, Beznoskova, Petra, Wagner, Susan, Valasek, Leos S, Jansen, Myrte E   +4 more
core   +1 more source

The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment

American Journal of Physiology - Endocrinology and Metabolism, 2013
Ronald Wek, Tracy G Anthony
exaly   +2 more sources

Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria. [PDF]

PLoS ONE, 2018
The identification of inhibitors of eukaryotic protein biosynthesis, which are targeting single translation factors, is highly demanded. Here we report on a small molecule inhibitor, gephyronic acid, isolated from the myxobacterium Archangium gephyra ...
Yazh Muthukumar, Johanna Münkemer, Daniel Mathieu, Christian Richter, Harald Schwalbe, Heinrich Steinmetz, Wolfgang Kessler, Joachim Reichelt, Ulrike Beutling, Ronald Frank, Konrad Büssow, Joop van den Heuvel, Mark Brönstrup, Richard E Taylor, Sabine Laschat, Florenz Sasse   +15 more
doaj   +1 more source

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase [PDF]

, 2012
eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called ...
Hussain, Nusrat, Proud, Christopher G, Proud, C., Wang, Xuemin, Rider, M., Rider, Mark H, Pyr Dit Ruys, S., Vertommen, D., Rider, Mark, Pyr Dit Ruys, Sébastien, Herinckx, Gaëtan, Vertommen, Didier, Herinckx, G., Smith, Ewan M, Wang, X., Smith, E., Hussain, N.   +16 more
core   +1 more source

Folding transitions during assembly of the eukaryotic mRNA cap-binding complex. [PDF]

, 2006
The cap-binding protein eIF4E is the first in a chain of translation initiation factors that recruit 40S ribosomal subunits to the 5' end of eukaryotic mRNA. During cap-dependent translation, this protein binds to the 5'-terminal m(7)Gppp cap of the mRNA,
von der Haar, Tobias, Ptushkina, Marina, Wagner, Gerhard, McCarthy, John E G, Moerke, Nathan, Oku, Yuko, McCarthy, John E. G., Mccarthy, John, Gross, John D.   +8 more
core   +1 more source

Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E

Molecules, 2016
Preparations of Deguelia duckeana, known in Brazil as timbó, are used by indigenous people to kill fish. Reinvestigation of its extracts resulted in the isolation and identification of 11 known flavonoids identified as 3,5,4’-trimethoxy-4-prenylstilbene (
Lorena M. C. Cursino, Nerilson M. Lima, Renato Murillo, Cecilia V. Nunez, Irmgard Merfort, Matjaz Humar   +5 more
doaj   +1 more source

A comprehensive analysis of the importance of translation initiation factors for Haloferax volcanii applying deletion and conditional depletion mutants [PDF]

, 2013
Translation is an important step in gene expression. The initiation of translation is phylogenetically diverse, since currently five different initiation mechanisms are known.
Jörg Soppa, Schmitt, Jessica, Schulz, Sebastian, Näther, Daniela, Katrin Gäbel (484917), Jessica Schmitt (147351), Katrin Gäbel, Gäbel, Katrin, Daniela J Näther, Sebastian Schulz, Soppa, Jörg, Sebastian Schulz (484918), Jörg Soppa (23130), Daniela J. Näther (484919), Jessica Schmitt   +14 more
core   +1 more source

Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling

eLife, 2016
Internal ribosome entry sites (IRESs) are important RNA-based translation initiation signals, critical for infection by many pathogenic viruses. The hepatitis C virus (HCV) IRES is the prototype for the type 3 IRESs and is also invaluable for exploring ...
Zane A Jaafar, Akihiro Oguro, Yoshikazu Nakamura, Jeffrey S Kieft   +3 more
doaj   +1 more source

Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed −1 ribosomal frameshifting

Cell Reports, 2023
Summary: Many positive-strand RNA viruses, including all known coronaviruses, employ programmed −1 ribosomal frameshifting (−1 PRF) to regulate the translation of polycistronic viral RNAs.
Lian-Huan Wei, Yu Sun, Junjie U. Guo
doaj   +1 more source

Upregulation of a novel eukaryotic translation initiation factor 5A (eIF5A) in dengue 2 virus-infected mosquito cells

Virology Journal, 2010
Background Dengue virus, a mosquito-borne flavivirus, is the etiological agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. It generally induces apoptosis in mammalian cells, but frequently results in persistent infection in ...
Shih Yu-Tzu, Yang Chao-Fu, Chen Wei-June
doaj   +1 more source