Results 21 to 30 of about 119,956 (261)

Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells

Scientific Reports, 2021
The eukaryotic elongation factor-2 kinase, eEF2K, which restricts protein translation elongation, has been identified as a potential therapeutic target for diverse types of malignancies including triple negative breast cancer (TNBC).
YoungJun Ju, Yaacov Ben-David, Daniela Rotin, Eldad Zacksenhaus   +3 more
doaj   +1 more source

A role for eIF5A in translational control of stress-inducible proteins in multiple myeloma cell lines. [PDF]

Mol Oncol
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Both D, Derks IAM, Vanleyssem R, Leclercq M, El Hachem N, Close P, Eldering E, Haselager MV.   +7 more
europepmc   +2 more sources

Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling

Journal of Lipid Research, 2009
Glucosamine impairs hepatic apolipoprotein B100 (apoB100) production by inducing endoplasmic reticulum (ER) stress and enhancing cotranslational and posttranslational apoB100 degradation (Qiu, W., R. K. Avramoglu, A. C. Rutledge, J. Tsai, and K.
Wei Qiu, Qiaozhu Su, Angela C. Rutledge, Jing Zhang, Khosrow Adeli   +4 more
doaj   +1 more source

OseIF3h Regulates Plant Growth and Pollen Development at Translational Level Presumably through Interaction with OsMTA2

Plants, 2021
The initiation stage of protein biosynthesis is a sophisticated process tightly regulated by numerous initiation factors and their associated components. However, the mechanism underlying translation initiation has not been completely understood in rice.
Yuqing Huang, Peng Zheng, Xuejiao Liu, Hao Chen, Jumin Tu   +4 more
doaj   +1 more source

The use of [14C]eukaryotic initiation factor 2 to measure the endogenous pool size of eukaryotic initiation factor 2 in rabbit reticulocyte lysate.

Journal of Biological Chemistry, 1979
[14C]Eukaryotic initiation factor 2 (eIF-2), obtained by reductive methylation of the purified initiation factor, was shown to be active in the unfractionated reticulocyte lysate. This allowed a direct measurement of the endogenous pool size of eIF-2 in rabbit reticulocyte lysate according to the principle of isotope dilution.
B, Safer, W, Kemper, R, Jagus
openaire   +2 more sources

Unanticipated antigens: translation initiation at CUG with leucine.

PLoS Biology, 2004
Major histocompatibility class I molecules display tens of thousands of peptides on the cell surface for immune surveillance by T cells. The peptide repertoire represents virtually all cellular translation products, and can thus reveal a foreign presence
Susan R Schwab, Jessica A Shugart, Tiffany Horng, Subramaniam Malarkannan, Nilabh Shastri   +4 more
doaj   +1 more source

Reactivity of vertebrate-directed phospho-eEF2 antibody against the Caenorhabditis elegans orthologue phospho-EEF-2 [version 1; referees: 2 approved]

F1000Research, 2015
Eukaryotic protein translation is divided into three mains stages: initiation, elongation and termination. Regulation of this process occurs at the initiation and elongation step.
Viviane Alves
doaj   +1 more source

Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs

Life Science Alliance, 2020
This study highlights the role of transglutaminase 2 in selective mRNA translation of hypoxic cancer cells by polyamination-dependent modulation of 4EBPs, providing a target for cancer treatment.
Sung-Yup Cho, Seungun Lee, Jeonghun Yeom, Hyo-Jun Kim, Jin-Haeng Lee, Ji-Woong Shin, Mee-ae Kwon, Ki Baek Lee, Eui Man Jeong, Hee Sung Ahn, Dong-Myung Shin, Kyunggon Kim, In-Gyu Kim   +12 more
doaj   +1 more source

Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation

Data in Brief, 2017
The data described in this article are related to “High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans” (Manfrini et ...
Nicola Manfrini, Sara Ricciardi, Annarita Miluzio, Maya Fedeli, Alessandra Scagliola, Simone Gallo, Thure Adler, Dirk H. Busch, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Stefano Biffo   +11 more
doaj   +1 more source

A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response

Frontiers in Molecular Neuroscience, 2023
ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the integrated stress response. The integrated stress response is triggered by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 complex ...
Graham Neill, Glenn R. Masson
doaj   +1 more source