Results 71 to 80 of about 173,490 (195)

Hepatitis E Virus Protease Inhibits the Activity of Eukaryotic Initiation Factor 2-Alpha Kinase 4 and Promotes Virus Survival. [PDF]

J Virol, 2023
Kumar A, Subramani C, Raj S, Ranjith-Kumar CT, Surjit M.   +4 more
europepmc   +1 more source

DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation.

PLoS Biology, 2018
The succession of molecular events leading to eukaryotic translation reinitiation-whereby ribosomes terminate translation of a short open reading frame (ORF), resume scanning, and then translate a second ORF on the same mRNA-is not well understood ...
Yasar Luqman Ahmed, Sibylle Schleich, Jonathan Bohlen, Nicolas Mandel, Bernd Simon, Irmgard Sinning, Aurelio A Teleman   +6 more
doaj   +1 more source

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses

mBio, 2017
As obligate parasites, viruses strictly depend on host cell translation for the production of new progeny, yet infected cells also synthesize antiviral proteins to limit virus infection. Modulation of host cell translation therefore represents a frequent
Hanna Roth, Vera Magg, Fabian Uch, Pascal Mutz, Philipp Klein, Katharina Haneke, Volker Lohmann, Ralf Bartenschlager, Oliver T. Fackler, Nicolas Locker, Georg Stoecklin, Alessia Ruggieri   +11 more
doaj   +1 more source

Eukaryotic initiation factor-2, gamma subunit, suppresses proliferation and regulates the cell cycle via the MAPK/ERK signaling pathway in acute myeloid leukemia. [PDF]

J Cancer Res Clin Oncol, 2021
Lu J, Chen S, Tan H, Huang Z, Li B, Liu L, Chen Y, Zeng X, Zou Y, Xu L.   +9 more
europepmc   +1 more source

Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation

Journal of Biological Chemistry, 1979
The AUG-dependent formation of an 80 S ribosomal initiation complex was studied using purified rabbit reticulocyte initiation factors radiolabeled by reductive methylation. The radiolabeled initiation factors were as biologically active as untreated factors.
D T, Peterson, W C, Merrick, B, Safer
openaire   +2 more sources

Indirect inactivation of eukaryotic initiation factor 2 in reticulocyte lysate by selenite.

Journal of Biological Chemistry, 1980
Addition of selenite to rabbit reticulocyte lysate produces a biphasic pattern of translational inhibition. Sucrose density gradient shows that the onset of translational inhibition is accompanied by decreased Met-tRNAf binding to 43 SN ribosomal subunits and loss of polysomes.
B, Safer, R, Jagus, D, Crouch
openaire   +2 more sources

Exploring the interaction dynamics of eukaryotic translation initiation factor 2

Biochemical Society Transactions
Eukaryotic translation initiation typically involves recruitment of the 43S ribosomal pre-initiation complex (PIC) to the 5′-end of the mRNA to form the 48S PIC, followed by scanning in search of a start codon in a favorable nucleotide complex. The start codon is recognized through base-pairing with the anticodon of the initiator Met-tRNAi.
openaire   +2 more sources

Targeting eIF4A with RNA Aptamers Enhances Salt Stress Tolerance in Rice Through Modulation of Translation Initiation

Rice
Salt stress is a major limiting factor for rice productivity worldwide, and improving salt tolerance is crucial for ensuring sustainable agricultural production.
Haomin Chen, Zhihao Xie, Mingming Chen, Peiyi Zhu, Daming Chen, Yongxiang Huang, Shuangfeng Dai   +6 more
doaj   +1 more source

The Potential Mechanism of ZFX Involvement in the Cell Growth

Research in Molecular Medicine, 2016
Background:The zinc-finger X linked (ZFX) gene encodes a transcription factor that acts as a regulator of self-renewal of stem cells. Due to the role of ZFX in cell growth, understanding ZFX protein-protein interactions helps to clarify its proper ...
Mahboube Ganji arjenaki, Parvaneh Nikpour, Mojtaba Emadi-bygi   +2 more
doaj  

The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression

Nature Communications
Eukaryotic initiation translation factor 3 subunit h (EIF3H) plays critical roles in regulating translational initiation and predicts poor cancer prognosis, but the mechanism underlying EIF3H tumorigenesis remains to be further elucidated.
Huilin Jin, Xiaoling Huang, Qihao Pan, Ning Ma, Xiaoshan Xie, Yue Wei, Fenghai Yu, Weijie Wen, Boyu Zhang, Peng Zhang, Xijie Chen, Jie Wang, Ran-yi Liu, Junzhong Lin, Xiangqi Meng, Mong-Hong Lee   +15 more
doaj   +1 more source