Results 41 to 50 of about 6,679,772 (342)
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
The historical regions of Europe: civilizational backgrounds and multiple routes to modernity [PDF]
, 2012 A systematic typology or comparative analysis of European historical regions does not exist and there is relatively little literature on the topic. The argument in this paper is that a six-fold classification is needed to capture the diversity of Europe ...
Delanty, Gerard
core +2 more sources
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Waveguide coupled III-V photodiodes monolithically integrated on Si
Nature Communications, 2022 To realize on-chip optical communication schemes based on silicon, the integration of waveguides onto III-V devices must be achieved. Here, the authors report waveguide-coupled III-V heterostructure photodiodes monolithically integrated on silicon ...
Pengyan Wen +10 more
doaj +1 more source
, 2004 Since the be ginning of the 1990s, organic farm ing has rapidly developed in almost all European countries. Growth has, however, slowed down recently. According to the Swiss Research Institute of Or ganic Agriculture FiBL, by the 31.12.2002 in the 15 ...
Richter, Toralf, Willer, Helga
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
, 2017 Europe Faces Europe examines Eastern European perspectives on European identity. The contributors to this volume map narratives of Europe rooted in Eastern Europe, examining their relationship to p ...
openaire +2 more sources
A multi-timescale synaptic weight based on ferroelectric hafnium zirconium oxide
Communications Materials, 2023 Brain-inspired neuromorphic computing is a key technology for processing an ever-growing amount of data. Here, an artificial synapse with dual resistance modulation mechanisms is demonstrated, achieving a dynamic range of 60, an endurance exceeding 1010 ...
Mattia Halter +6 more
doaj +1 more source