Results 71 to 80 of about 6,711,797 (295)

The need for ‘Diamond Engagement’ around open access to high quality research output [PDF]

This paper advocates for a co-ordinated cultural shift in their engagement with access to resources in order to make peer-reviewed articles available to a wider audience.
Science Europe
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Vaccinated and unvaccinated need to coexist with tolerance and respect

The Lancet Regional Health. Europe, 2022
The Lancet Regional Health – Europe
doaj   +1 more source

Impact of interface traps on charge noise and low-density transport properties in Ge/SiGe heterostructures

Communications Materials
Hole spins in Ge/SiGe heterostructures have emerged as an interesting qubit platform with favourable properties such as fast electrical control and noise-resilient operation at sweet spots.
Leonardo Massai, Bence Hetényi, Matthias Mergenthaler, Felix J. Schupp, Lisa Sommer, Stephan Paredes, Stephen W. Bedell, Patrick Harvey-Collard, Gian Salis, Andreas Fuhrer, Nico W. Hendrickx   +10 more
doaj   +1 more source

Urban Pluvial Flood Risk in Romania, in the Context of Floods Directive Implementation [PDF]

Aerul şi Apa: Componente ale Mediului
Romania is a flood prone country and same are her cities. Pluvial floods can occur in urban or rural areas without a direct connection with river or a water body. As part of the Floods Directive implementation, Romania has identified, in the first cycle,
T. SAMPSON, D. RĂDULESCU, M.B. ION, A. COZMA   +3 more
doaj   +1 more source

Global governance: an agenda for Europe [PDF]

Governance of the global economy is becoming a pressing matter and the situation is compounded by the growing number and diversity of players in the global economy. The authors argue that Europe is now in a position to take a leading role. Not only is it
Alan Ahearne, André Sapir, Jean Pisani-Ferry, Nicolas Véron   +3 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Beyond the crisis: prospects for emerging Europe [PDF]

This working paper by Zsolt Darvas assesses the impact of the 2008-09 global financial and economic crisis on the medium-term growth prospects of CEES countries, the Caucasus and Central Asia, which starting their economic transition about twenty years ...
Zsolt Darvas
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Highly reproducible and CMOS-compatible VO2-based oscillators for brain-inspired computing

Scientific Reports
With remarkable electrical and optical switching properties induced at low power and near room temperature (68 °C), vanadium dioxide (VO2) has sparked rising interest in unconventional computing among the phase-change materials research community.
Olivier Maher, Roy Bernini, Nele Harnack, Bernd Gotsmann, Marilyne Sousa, Valeria Bragaglia, Siegfried Karg   +6 more
doaj   +1 more source