Results 71 to 80 of about 6,083,536 (363)

On the Neutrality of Flowshop Scheduling Fitness Landscapes [PDF]

open access: yes, 2012
Solving efficiently complex problems using metaheuristics, and in particular local searches, requires incorporating knowledge about the problem to solve. In this paper, the permutation flowshop problem is studied. It is well known that in such problems, several solutions may have the same fitness value.
arxiv   +1 more source

Introduction [PDF]

open access: yes, 2016
This book investigates restructuring in the electronics industry and in particular the impact of a \u2018Chinese\u2019 labour regime on work and employ - ment practices in electronics assembly in Europe.1 Electronics is an extremely dynamic sector ...
Andrijasevic, Rutvica   +2 more
core  

The Shelleys and the Idea of Europe [PDF]

open access: yes, 2008
This article explores how the Shelleys and their circle configure ideas of “Europe” between January 1817 and March 1818. I begin with Frankenstein, discussing how Mary Shelley associates Frankenstein's experiment with the particularly “European” problem ...
Stock, Paul
core   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

open access: yesFEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez   +3 more
wiley   +1 more source

Foundation models for materials discovery – current state and future directions

open access: yesnpj Computational Materials
Large language models, commonly known as LLMs, are showing promise in tacking some of the most complex tasks in AI. In this perspective, we review the wider field of foundation models—of which LLMs are a component—and their application to the field of ...
Edward O. Pyzer-Knapp   +7 more
doaj   +1 more source

Declining trends of healthy life years expectancy (HLYE) in Europe [PDF]

open access: yesarXiv, 2013
We examine the trends in Healthy Life Years Expectancy (HLYE) at birth during the past few decades in Europe. We observe that several European countries show a significant drop in HLYE at birth starting from 2003; interrupting what had been a previous continuous increase.
arxiv  

Analyzing the Effect of Objective Correlation on the Efficient Set of MNK-Landscapes [PDF]

open access: yes, 2012
In multiobjective combinatorial optimization, there exists two main classes of metaheuristics, based either on multiple aggregations, or on a dominance relation. As in the single objective case, the structure of the search space can explain the difficulty for multiobjective metaheuristics, and guide the design of such methods.
arxiv   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

open access: yesFEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek   +15 more
wiley   +1 more source

What can we do to Fight Discrimination? [PDF]

open access: yes, 2003
[Excerpt] Inclusion Europe speaks for people with intellectual disability and their families.
Inclusion Europe
core   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

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