Results 141 to 150 of about 129,071 (299)

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

open access: yesAdvanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu   +12 more
wiley   +1 more source

Rabbit meat processing and traceability

open access: yes, 2004
Rabbit meat is a highly digestible, tasty, low-calorie food, often recommended by nutritionists over other meats, yet it is still considered a niche product, especially because of its time consuming preparation which requires culinary skills and because ...
PETRACCI, MASSIMILIANO, CAVANI, CLAUDIO
core  

DIALLEL CROSSBREEDING EXPERIMENT IN DANISH AND HUNGARIAN MEAT RABBITS 2. QUALITY EVALUATION, DISSECTION, AND CHEMICAL ANALYSIS OF CARCASSES

open access: yes, 1996
[EN] The two rabbit meat breeds, Danish White (O}, represented by a 3-way cross of 3 lines from the Danish lnstitute of Animal Science (DIAS), and Pannon White (H), represented by a synthetic breed from the Pannon Agricultura!
Jensen, J.A.   +6 more
core   +1 more source

Population genetics of the European rabbit along a rural-to-urban gradient. [PDF]

open access: yesSci Rep, 2020
Ziege M   +6 more
europepmc   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

open access: yesAdvanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti   +13 more
wiley   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

open access: yesAdvanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi   +13 more
wiley   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro   +7 more
wiley   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun   +27 more
wiley   +1 more source

Effect of artificial warren size on a restocked European wild rabbit population

open access: yes, 2017
From the time since the decline of the wild rabbit Oryctolagus cuniculus in southern Europe, various techniques and methods have been explored with a view to restoring wild rabbit populations or increasing rabbit resilience, for both conservation and ...
Rouco, Carlos   +3 more
core   +1 more source

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