Results 151 to 160 of about 4,359,057 (308)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

open access: yesAdvanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer   +9 more
wiley   +1 more source

Population genetics of the European rabbit along a rural-to-urban gradient. [PDF]

open access: yesSci Rep, 2020
Ziege M   +6 more
europepmc   +1 more source

Abstracts of the communications presented during the 6th World Rabbit Congress: GROWTH AND MEAT. Toulouse, July 9-12, 1996

open access: yes, 1996
World Rabbit Science (1996). Abstracts of the communications presented during the 6th World Rabbit Congress: GROWTH AND MEAT. Toulouse, July 9-12, 1996. World Rabbit Science. 04.
GROWTH AND MEAT,, World Rabbit Science
core   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

open access: yesAdvanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl   +20 more
wiley   +1 more source

Abstracts of the communications presented at the First Rabbit Conference of the Americas: Montecillo, Mexico. September 1998

open access: yes, 1999
World Rabbit Science (1999). Abstracts of the communications presented at the First Rabbit Conference of the Americas: Montecillo, Mexico. September 1998. World Rabbit Science. 07(1).
Montecillo, Mexico. September 1998,   +1 more
core   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

open access: yesAdvanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu   +17 more
wiley   +1 more source

Abstracts of the communications presented during the 6th World Rabbit Congress: GENETICS AND SELECTION. Toulouse, July 9-12, 1996

open access: yes, 1996
World Rabbit Science (1996). Abstracts of the communications presented during the 6th World Rabbit Congress: GENETICS AND SELECTION. Toulouse, July 9-12, 1996. World Rabbit Science. 04.
World Rabbit Science   +1 more
core   +1 more source

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

open access: yesAdvanced Science, EarlyView.
An innervated human skin equivalent is integrated with high‐density microelectrode arrays to reveal how engineered free nerve ending–like structures translate touch and temperature into electrical codes. Mechanical indentation and thermal stimulation engage the engineered somatosensory circuitry and evoke distinct firing and waveform signatures ...
Daniele Bellantoni   +6 more
wiley   +1 more source

Abstracts of the communications presented during the 6th World Rabbit Congress: ETHOLOGIE AND WELFARE. Toulouse, July 9-12, 1996

open access: yes, 1996
World Rabbit Science (1996). Abstracts of the communications presented during the 6th World Rabbit Congress: ETHOLOGIE AND WELFARE. Toulouse, July 9-12, 1996. World Rabbit Science. 04.
World Rabbit Science   +1 more
core   +1 more source

Home - About - Disclaimer - Privacy