Results 61 to 70 of about 338,553 (288)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The paradox of endangered European rabbits regarded as pests on the Iberian Peninsula: trends in subspecies matter

Endangered Species Research, 2020
The European rabbit Oryctolagus cuniculus faces a paradoxical situation in its native range on the Iberian Peninsula. While many populations have declined sharply due to a new variant of the rabbit haemorrhagic disease virus (RHDV-b), others remain ...
Vaquerizas, PH, Delibes-Mateos, M, Piorno, V, Arroyo, B, Castro, F, Villafuerte, R   +5 more
doaj   +1 more source

Comparison of predation by two suburban cats in New Zealand [PDF]

, 2017
To study the effects domestic cats may have on surrounding wildlife, a complete list was made of 558 items caught in the garden or brought into the house by one cat over 17 years, from 1988 to 2005.
Flux, John E.C.
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Whole-Genome Sequencing-Based Population Genetic Analysis of Wild and Domestic Rabbit Breeds

Animals
The European rabbit exists in the wild and has several highly bred domesticated forms. There are well-separated wild European rabbit populations, and intensive breeding has resulted in various forms and utilizations.
Zsófia Fekete, Zoltán Német, Nóra Ninausz, Péter Fehér, Mátyás Schiller, Maher Alnajjar, Áron Szenes, Tibor Nagy, Viktor Stéger, Levente Kontra, Endre Barta   +10 more
doaj   +1 more source

Large-scale lagovirus disease outbreaks in European brown hares (Lepus europaeus) in France caused by RHDV2 strains spatially shared with rabbits (Oryctolagus cuniculus)

Veterinary Research, 2017
Rabbit haemorrhagic disease virus (RHDV) is a lagovirus that causes rabbit haemorrhagic disease (RHD) in European rabbits (Oryctolagus cuniculus). In 2010, a new genotype called RHDV2 emerged in France. It exhibits a larger host range than classical RHDV
Ghislaine Le Gall-Reculé, Evelyne Lemaitre, Stéphane Bertagnoli, Céline Hubert, Sokunthea Top, Anouk Decors, Stéphane Marchandeau, Jean-Sébastien Guitton   +7 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

High rabbit abundance proves detrimental to the population growth rate in European rabbit (Oryctolagus cuniculus L.) extensive breeding enclosures

World Rabbit Science, 2014
The European rabbit (Oryctolagus cuniculus L.) is a key prey species in Mediterranean ecosystems that has declined in its natural ranges as a result of diseases and loss of habitat.
L. Ruiz-Aizpurua, J. Guerrero-Casado, A. J. Carpio, F. S. Tortosa   +3 more
doaj   +1 more source

Housing of rabbits – results of an European research network

European Poultry Science, 2006
The main welfare indicators to assess rabbit housing are mortality (unavoidable low), morbidity (unavoidable low), physiological parameters in the species-specific standard, species-specific behaviour and performance on a high level. Group housing of does with kits is possible if an individual electronic nest box recognition system is used.
Hoy, S., Ruis, M.A.W., Szendro, Z.
openaire   +2 more sources