Results 81 to 90 of about 334,584 (306)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Kinsloe Site (41GG3) on Rabbit Creek in the mid-Sabine River Basin, Gregg County, Texas [PDF]

, 2017
The Kinsloe site (41GG3) is on Rabbit Creek in the middle Sabine River basin a few miles north of Kilgore, Texas. The site is ca. 2 km west of the confluence of Rabbit Creek and the Sabine River.
Perttula, Timothy K.
core   +1 more source

Local variation in absolute water content of human and rabbit eye lenses measured by Raman microspectroscopy [PDF]

, 1989
Raman spectra were obtained from fresh, fixed and sliced rabbit lenses and from human lens slices. For all lenses and lens slices the ratio R, defined as the Raman intensity at 3390 cm−1 divided by the Raman intensity at 2935 cm−1, was measured at ...
Bot, Annet C.C., Greve, Jan, Huizinga, Alex, Mul, Frits F.M. de, Vrensen, Gijs F.J.M.   +4 more
core   +4 more sources

Control of the European rabbit in central Spain [PDF]

European Journal of Wildlife Research, 2013
The European rabbit is a growing problem for agriculture in parts of its natural range. In this study, our aim was to use historical records over two periods within the last 50 years to analyze trends in the number of requests made for rabbit control in Central Spain.
Ríos-Saldaña, Carlos Antonio, Delibes-Mateos, Miguel, Castro, Francisca, Martínez, Emilia, Vargas, J. Mario, Cooke, Brian D., Villafuerte, Rafael   +6 more
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum [PDF]

, 2015
The neuronal serpin neuroserpin undergoes polymerisation as a consequence of point mutations that alter its conformational stability, leading to a neurodegenerative dementia called familial encephalopathy with neuroserpin inclusion bodies (FENIB ...
Dalton, Lucy, Gooptu, Bibek, GUADAGNO, NOEMI ANTONELLA, Irving, James A, Lomas, David A, LUPO, GIUSEPPE, Manno, Mauro, Marciniak, Stefan J, Martorana, Vincenzo, MIRANDA BANOS, MARIA ELENA, MORICONI, CLAUDIA, Noto, Rosina, Ordoñez, Adriana, Timpano, Valentina   +13 more
core   +3 more sources

Uncovering the microbiome of invasive sympatric European brown hares and European rabbits in Australia

PeerJ, 2019
Background European brown hares ( Lepus europaeus ) and European rabbits ( Oryctolagus cuniculus ) are invasive pest species in Australia, with rabbits having a substantially larger environmental impact
Somasundhari Shanmuganandam, Yiheng Hu, Tanja Strive, Benjamin Schwessinger, Robyn N. Hall   +4 more
openaire   +4 more sources

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

Outbreaks of myxomatosis in Egyptian domestic rabbit farms

World Rabbit Science, 2019
Myxomatosis is an endemic infectious, severe and often fatal disease of rabbit caused by myxoma virus. In the present study, myxomatosis outbreaks were reported in 7 domestic rabbit farms in Egypt.
H. M. Salem, E. A. Morsy, E. I. Hassanen, A. A. Shehata   +3 more
doaj   +1 more source