Results 61 to 70 of about 334,584 (306)

cAMP-Inhibits Cytoplasmic Phospholipase A(2) and Protects Neurons against Amyloid-beta-Induced Synapse Damage [PDF]

, 2015
A key event in Alzheimer’s disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage as measured by the loss of synaptic proteins. α-synuclein (αSN), aggregates of which accumulate
Bate, C, Williams, A
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The effect of rabbit (Oryctolagus cuniculus cuniculus) (Linnaeus, 1758) browsing on seedling survival : a thesis presented in part fulfillment of the requirements for the degree of Master of Science in Zoology at Massey University, Palmerston North, New Zealand [PDF]

, 2004
The European rabbit, Oryctolagus cuniculus (Linnaeus 1758) is a small 2-4 kg cutherian mammal introduced into New Zealand from the United Kingdom in the mid 1800's.
Doyle, Paul Andrew
core  

Long-term decline of the European wild rabbit (Oryctolagus cuniculus) in south-western Spain [PDF]

, 2007
The European wild rabbit (Oryctolagus cuniculus) is a species native to the Iberian Peninsula, where it was once extremely abundant. It is considered the most important prey item for the peninsula's assemblage of Mediterranean vertebrate predators, which
Ayala, José, Beltrán Gala, Juan Francisco, Cabezas, Sonia, Castro, Francisca, Cotilla, Irene, Jiménez, Antonio, Jordan, Gloria, Kufner, M.B, Laffite, Rafael, Moreno, Sacramento, Quintero, Carmen, Villafuerte, Rafael   +11 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

High rabbit abundance proves detrimental to the population growth rate in European rabbit (Oryctolagus cuniculus L.) extensive breeding enclosures

World Rabbit Science, 2014
The European rabbit (Oryctolagus cuniculus L.) is a key prey species in Mediterranean ecosystems that has declined in its natural ranges as a result of diseases and loss of habitat.
L. Ruiz-Aizpurua, J. Guerrero-Casado, A. J. Carpio, F. S. Tortosa   +3 more
doaj   +1 more source

Housing of rabbits – results of an European research network

European Poultry Science, 2006
The main welfare indicators to assess rabbit housing are mortality (unavoidable low), morbidity (unavoidable low), physiological parameters in the species-specific standard, species-specific behaviour and performance on a high level. Group housing of does with kits is possible if an individual electronic nest box recognition system is used.
Hoy, S., Ruis, M.A.W., Szendro, Z.
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A pandemic strain of calicivirus threatens rabbit industries in the Americas

Virology Journal, 2007
Rabbit Hemorrhagic Disease (RHD) is a severe acute viral disease specifically affecting the European rabbit Oryctolagus cuniculus. As the European rabbit is the predominant species of domestic rabbit throughout the world, RHD contributes towards ...
Botti Giuliana, Ward Gordon B, Neilan John G, Burrage Thomas G, Moran Karen E, Lu Zhiqiang, Mohamed Fawzi M, Behan Shawn C, McIntosh Michael T, Capucci Lorenzo, Metwally Samia A   +10 more
doaj   +1 more source

Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres [PDF]

, 2015
A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres.
Dietmar Steverding, Eugene Akujuru, Feliciano Protasi, Gabriel Mutungi, Goldberg AL, Lewis Arthurton, Simona Boncompagni, Timothy Pearson, Wing SS   +8 more
core   +1 more source