Results 101 to 110 of about 9,251,887 (309)

The United States and the European Community, 1969-1974: an uneasy partnership [PDF]

open access: yesEastern Journal of European Studies, 2016
The relations between the United States and the European Community under the Nixon Administration (1969-1974) were considerably changing. Post-1945 cooperation and dependence increasingly gave way to economic competition and division in military and ...
Thi Thuy Hang NGUYEN
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Are European welfare states sustainable? [PDF]

open access: yes
European welfare states face serious financial difficulties caused by persistent high levels of unemployment and demographic ageing. Serious organisational problems are accompanied by inefficiency.
Delsen, Lei
core  

Transaction costs in the European Security and Defense Policy (ESDP): Understanding the United States' impact on European security [PDF]

open access: yes, 2009
The objective of the paper is to introduce a comprehensive approach to the emergence of the European Union’s security and defence policy (ESDP) in 1998/9.
Weiss, Moritz
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

The European Transformation of Modern Turkey. CEPS Paperback. September 2004 [PDF]

open access: yes, 2004
The outcome of a research project carried out by CEPS and the Economics and Foreign Policy Forum (EFPF) of Istanbul, this book examines in detail the challenges and opportunities that would arise with Turkey’s full membership of the European Union.
Ülgen, Sinan   +3 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

European Union’s Member States Sovereignty [PDF]

open access: yes
Knowing that the European Union, as an union of sovereign states, was incorporated in the form of an international organization with competences higher than the state’s, seeing also that it has international legal personality, being a subject of ...
Anghel, Ion M.
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

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