Results 51 to 60 of about 69,598 (254)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Breeding like rabbits: global patterns of variability and determinants of European wild rabbit reproduction

open access: yesEcography, 2009
The importance of European wild rabbits Oryctolagus cuniculus both as a pest in some areas and as a key prey species in others emphasizes the need to understand what controls its population dynamics worldwide.
Tablado, Zulima   +2 more
openaire   +2 more sources

An in vivo system for directed experimental evolution of rabbit haemorrhagic disease virus. [PDF]

open access: yesPLoS ONE, 2017
The calicivirus Rabbit haemorrhagic disease virus (RHDV) is widely used in Australia as a biocontrol agent to manage wild European rabbit (Oryctolagus cuniculus) populations.
Robyn N Hall   +6 more
doaj   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

open access: yesAdvanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino   +12 more
wiley   +1 more source

Seasonal habitat use by the European rabbit (Oryctolagus cuniculus) in a coastal dune system in SW Spain [PDF]

open access: yesAnimal Biodiversity and Conservation, 2014
We studied habitat use by the wild European rabbit (Oryctolagus cuniculus) in a coastal sand dune system in the south–western Iberian peninsula. Our goals were to define the use of this habitat by rabbits in relation to food and shelter availability ...
Dellafiore, C. M.   +3 more
doaj  

Keeping an eye on the use of eye-lens weight as a universal indicator of age for European wild rabbits

open access: yesScientific Reports, 2021
Accurate methods for age determination are critical to the knowledge of wildlife populations' age structure and, therefore, to their successful management.
Patricia H. Vaquerizas   +4 more
doaj   +1 more source

Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge model for Human Skin and its Diseases

open access: yesAdvanced Healthcare Materials, EarlyView.
Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova   +4 more
wiley   +1 more source

Exploring the Genetic Background of the Differences in Nest-Building Behavior in European Rabbit

open access: yesAnimals, 2020
Once a day, nursing and absentee mothering make the wild rabbit (Oryctolagus cuniculus) an ideal model animal for measuring differences in maternal behavior.
Ildikó Benedek   +3 more
doaj   +1 more source

Parasitic infections of wild rabbits and hares [PDF]

open access: yesVeterinarski Glasnik, 2014
The paper presents the most important parasitic infections of wild rabbits and hares, which harmful effect in this animal population is manifested as a gradual weakening of the immune system, reduction in fertility, weight loss and constant ...
Ilić Tamara   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy