Results 1 to 10 of about 1,038,892 (123)
Journal for ImmunoTherapy of Cancer, 2020 Background Oncolytic therapy uses live-replicating viruses to improve the immunological status of treated tumors. Critically, while these viruses are known to self-amplify in vivo, clinical oncolytic therapies still appear to display a strong dose ...
Eric Bartee +2 more
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Systemic therapy with oncolytic myxoma virus cures established residual multiple myeloma in mice
Molecular Therapy: Oncolytics, 2016 Multiple myeloma is an incurable malignancy of plasma B-cells. Traditional chemotherapeutic regimes often induce initial tumor regression; however, virtually all patients eventually succumb to relapse caused by either reintroduction of disease during ...
Eric Bartee +3 more
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Molecular Therapy - Oncolytics, 2020 Oncolytic viruses can target neoplasms, triggering oncolytic and immune effects. Their delivery to melanoma lesions remains challenging. Bone-marrow-derived mesenchymal stem cells (MSCs) were shown to be permissive for oncolytic myxoma virus (MYXV ...
Joanna Jazowiecka-Rakus +2 more
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Myxoma Virus and the Leporipoxviruses: An Evolutionary Paradigm
Viruses, 2015 Myxoma virus (MYXV) is the type species of the Leporipoxviruses, a genus of Chordopoxvirinae, double stranded DNA viruses, whose members infect leporids and squirrels, inducing cutaneous fibromas from which virus is mechanically transmitted by biting ...
Isabella Cattadori +2 more
exaly +3 more sources
Recombinant Myxoma Virus Expressing Walleye Dermal Sarcoma Virus orfC Is Attenuated in Rabbits
Viruses, 2020 The poxvirus, myxoma virus (MYXV) has shown efficacy as an oncolytic virus (OV) in some cancer models. However, MYXV replication within murine cancer models and spontaneous canine sarcomas is short-lived.
Sandra L Quackenbush +2 more
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PathogensThis study aimed to explore the effectiveness and safety of Myxoma virus (MYXV) in MM cell lines and primary myeloma cells obtained from patients with multiple myeloma. Myeloma cells were isolated from MM patients and cultured.
Burhan Turgut +2 more
exaly +3 more sources
Comparative characterization of Leporipoxvirus members’ reproduction in continuous cell culture
Ветеринария сегодня, 2021 Examination of the virus-cell interactions is of both scientific and practical importance. Our study was aimed at comparative characterization of rabbit myxoma virus and Shope fibroma virus biological properties that manifested during the virus ...
O. G. Lapteva +3 more
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Metabolic signatures associated with oncolytic myxoma viral infections
Scientific Reports, 2022 Oncolytic viral therapy is a recent advance in cancer treatment, demonstrating promise as a primary treatment option. To date, the secondary metabolic effects of viral infection in cancer cells has not been extensively studied.
Rohit Mahar +7 more
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PLoS ONE, 2012 Plasmacytoid dendritic cells (pDCs) play important roles in antiviral innate immunity by producing type I interferon (IFN). In this study, we assess the immune responses of primary human pDCs to two poxviruses, vaccinia and myxoma virus.
Hua Cao +15 more
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Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses
Emerging Infectious Diseases, 2011 Myxomatosis in Europe is the result of the release of a South America strain of myxoma virus in 1952. Several attenuated strains with origins in South America or California have since been used as vaccines in the rabbit industry.
Christelle Camus-Bouclainville +5 more
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