Divergent Evolutionary Pathways of Myxoma Virus in Australia: Virulence Phenotypes in Susceptible and Partially Resistant Rabbits Indicate Possible Selection for Transmissibility [PDF]
Journal of Virology, 2022 Isabella Cattadori +2 more
exaly +2 more sources
Comparative characterization of Leporipoxvirus members’ reproduction in continuous cell culture
Ветеринария сегодня, 2021 Examination of the virus-cell interactions is of both scientific and practical importance. Our study was aimed at comparative characterization of rabbit myxoma virus and Shope fibroma virus biological properties that manifested during the virus ...
O. G. Lapteva +3 more
doaj +1 more source
Metabolic signatures associated with oncolytic myxoma viral infections
Scientific Reports, 2022 Oncolytic viral therapy is a recent advance in cancer treatment, demonstrating promise as a primary treatment option. To date, the secondary metabolic effects of viral infection in cancer cells has not been extensively studied.
Rohit Mahar +7 more
doaj +1 more source
PLoS ONE, 2012 Plasmacytoid dendritic cells (pDCs) play important roles in antiviral innate immunity by producing type I interferon (IFN). In this study, we assess the immune responses of primary human pDCs to two poxviruses, vaccinia and myxoma virus.
Hua Cao +15 more
doaj +1 more source
Oncolytic myxoma virus: The path to clinic [PDF]
Vaccine, 2013 Many common neoplasms are still noncurative with current standards of cancer therapy. More therapeutic modalities need to be developed to significantly prolong the lives of patients and eventually cure a wider spectrum of cancers. Oncolytic virotherapy is one of the promising new additions to clinical cancer therapeutics.
Winnie M, Chan +2 more
openaire +3 more sources
Systemic therapy with oncolytic myxoma virus cures established residual multiple myeloma in mice
Molecular Therapy: Oncolytics, 2016 Multiple myeloma is an incurable malignancy of plasma B-cells. Traditional chemotherapeutic regimes often induce initial tumor regression; however, virtually all patients eventually succumb to relapse caused by either reintroduction of disease during ...
Eric Bartee +3 more
doaj +1 more source
Genetic Variability of Myxoma Virus Genomes [PDF]
Journal of Virology, 2017 ABSTRACTMyxomatosis is a recurrent problem on rabbit farms throughout Europe despite the success of vaccines. To identify gene variations of field and vaccine strains that may be responsible for changes in virulence, immunomodulation, and immunoprotection, the genomes of 6 myxoma virus (MYXV) strains were sequenced: German field isolates Munich-1, FLI ...
Braun, Christoph +9 more
openaire +3 more sources
Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses
Emerging Infectious Diseases, 2011 Myxomatosis in Europe is the result of the release of a South America strain of myxoma virus in 1952. Several attenuated strains with origins in South America or California have since been used as vaccines in the rabbit industry.
Christelle Camus-Bouclainville +5 more
doaj +1 more source
Virotherapy using myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells. [PDF]
PLoS ONE, 2012 Graft-versus-host disease (GVHD) is a potentially lethal clinical complication arising from the transfer of alloreactive T lymphocytes into immunocompromised recipients.
Eric Bartee +4 more
doaj +1 more source
Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity. [PDF]
PLoS ONE, 2014 Myxoma virus, a rabbit poxvirus, can efficiently infect various types of mouse and human cancer cells. It is a strict rabbit-specific pathogen, and is thought to be safe as a therapeutic agent in all non-rabbit hosts tested including mice and humans ...
Vesna Tosic +7 more
doaj +1 more source