Detection of Recombinant Hare Myxoma Virus in Wild Rabbits (Oryctolagus cuniculus algirus) [PDF]
Viruses, 2020 In late 2018, an epidemic myxomatosis outbreak emerged on the Iberian Peninsula leading to high mortality in Iberian hare populations. A recombinant Myxoma virus (strains MYXV-Tol and ha-MYXV) was rapidly identified, harbouring a 2.8 kbp insertion ...
Fábio A. Abade dos Santos +9 more
doaj +2 more sources
A Replication-Defective Myxoma Virus Inducing Pro-Inflammatory Responses as Monotherapy and an Adjuvant to Chemo- and DC Immuno-Therapy for Ovarian Cancer [PDF]
VirusesMyxoma virus (MYXV), a rabbit-specific poxvirus and non-pathogenic in humans and mice, is an excellent candidate oncolytic virus for cancer therapy. MYXV also has immunotherapeutic benefits.
Martin J. Cannon, Jia Liu
doaj +2 more sources
Coinfections of Novel Polyomavirus, Anelloviruses and a Recombinant Strain of Myxoma Virus-MYXV-Tol Identified in Iberian Hares [PDF]
Viruses, 2020 Viruses are ubiquitous in nature; however, very few have been identified in the Leporid species. In the fall of 2018, an outbreak of myxomatosis in Iberian hares (Lepus granatensis) was reported in Spain and a novel recombinant myxoma virus strain (MYXV ...
Ana Águeda-Pinto +6 more
doaj +2 more sources
Recombinant Myxoma Virus Expressing Walleye Dermal Sarcoma Virus orfC Is Attenuated in Rabbits [PDF]
Viruses, 2020 The poxvirus, myxoma virus (MYXV) has shown efficacy as an oncolytic virus (OV) in some cancer models. However, MYXV replication within murine cancer models and spontaneous canine sarcomas is short-lived.
Laura V. Ashton +6 more
doaj +2 more sources
Myxoma virusjumps species to the Iberian hare [PDF]
Transboundary and Emerging Diseases, 2019 The study of myxoma virus (MYXV) infections in the European rabbit (Oryctolagus cuniculus) has produced one of the most accepted host-pathogen evolutionary models. To date, myxomatosis has been limited to the European rabbit with sporadic reports in hares.
Kevin P. Dalton +13 more
openaire +3 more sources
Divergent Evolutionary Pathways of Myxoma Virus in Australia: Virulence Phenotypes in Susceptible and Partially Resistant Rabbits Indicate Possible Selection for Transmissibility [PDF]
Journal of Virology, 2022 Peter J Kerr +2 more
exaly +2 more sources
Comparative characterization of Leporipoxvirus members’ reproduction in continuous cell culture
Ветеринария сегодня, 2021 Examination of the virus-cell interactions is of both scientific and practical importance. Our study was aimed at comparative characterization of rabbit myxoma virus and Shope fibroma virus biological properties that manifested during the virus ...
O. G. Lapteva +3 more
doaj +1 more source
Metabolic signatures associated with oncolytic myxoma viral infections
Scientific Reports, 2022 Oncolytic viral therapy is a recent advance in cancer treatment, demonstrating promise as a primary treatment option. To date, the secondary metabolic effects of viral infection in cancer cells has not been extensively studied.
Rohit Mahar +7 more
doaj +1 more source
Oncolytic myxoma virus: The path to clinic [PDF]
Vaccine, 2013 Many common neoplasms are still noncurative with current standards of cancer therapy. More therapeutic modalities need to be developed to significantly prolong the lives of patients and eventually cure a wider spectrum of cancers. Oncolytic virotherapy is one of the promising new additions to clinical cancer therapeutics.
Winnie M, Chan +2 more
openaire +3 more sources
PLoS ONE, 2012 Plasmacytoid dendritic cells (pDCs) play important roles in antiviral innate immunity by producing type I interferon (IFN). In this study, we assess the immune responses of primary human pDCs to two poxviruses, vaccinia and myxoma virus.
Hua Cao +15 more
doaj +1 more source