Results 31 to 40 of about 4,101 (195)

Genetic Variability of Myxoma Virus Genomes [PDF]

Journal of Virology, 2017
ABSTRACTMyxomatosis is a recurrent problem on rabbit farms throughout Europe despite the success of vaccines. To identify gene variations of field and vaccine strains that may be responsible for changes in virulence, immunomodulation, and immunoprotection, the genomes of 6 myxoma virus (MYXV) strains were sequenced: German field isolates Munich-1, FLI ...
Braun, Christoph, Thürmer, Andrea, Daniel, Rolf, Schultz, Anne-Kathrin, Bulla, Ingo, Schirrmeier, Horst, Mayer, Dietmar, Neubert, Andreas, Czerny, Claus-Peter, McFadden, Grant   +9 more
openaire   +3 more sources

Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses

Emerging Infectious Diseases, 2011
Myxomatosis in Europe is the result of the release of a South America strain of myxoma virus in 1952. Several attenuated strains with origins in South America or California have since been used as vaccines in the rabbit industry.
Christelle Camus-Bouclainville, Magalie Gretillat, Robert Py, Jacqueline Gelfi, Jean-Luc Guérin, Stéphane Bertagnoli   +5 more
doaj   +1 more source

Virotherapy using myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells. [PDF]

PLoS ONE, 2012
Graft-versus-host disease (GVHD) is a potentially lethal clinical complication arising from the transfer of alloreactive T lymphocytes into immunocompromised recipients.
Eric Bartee, Amy Meacham, Elizabeth Wise, Christopher R Cogle, Grant McFadden   +4 more
doaj   +1 more source

M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit [PDF]

, 2009
Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Camus-Bouclainville, Christelle, Sophie Blanié, Blanié, Sophie, Christelle Camus-Bouclainville, Mortier, Jérémy, Stéphane Bertagnoli, Mortier, J, Maxence Delverdier, Bertagnoli, Stéphane, Jérémy Mortier, Delverdier, Maxence   +10 more
core   +1 more source

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity. [PDF]

PLoS ONE, 2014
Myxoma virus, a rabbit poxvirus, can efficiently infect various types of mouse and human cancer cells. It is a strict rabbit-specific pathogen, and is thought to be safe as a therapeutic agent in all non-rabbit hosts tested including mice and humans ...
Vesna Tosic, Diana L Thomas, David M Kranz, Jia Liu, Grant McFadden, Joanna L Shisler, Amy L MacNeill, Edward J Roy   +7 more
doaj   +1 more source

In vitro permissivity of bovine cells for wild-type and vaccinal myxoma virus strains [PDF]

, 2007
Myxoma virus (MYXV), a leporide-specific poxvirus, represents an attractive candidate for the generation of safe, non-replicative vaccine vector for non-host species.
Jean-Luc Duteyrat, Pignolet Béatrice, Stéphane Bertagnoli, Foucras Gilles, Béatrice Pignolet, Bertagnoli, Stéphane, Duteyrat, Jl, Aude Allemandou, Jacqueline Gelfi, Allemandou Aude, Bertagnoli Stéphane, Gelfi, Jacqueline, Foucras, Gilles, Duteyrat Jean-Luc, Gilles Foucras, Allemandou, Aude, Duteyrat, Jean-Luc, Pignolet, Béatrice, Gelfi Jacqueline   +18 more
core   +1 more source

Novel Trivalent Vectored Vaccine for Control of Myxomatosis and Disease Caused by Classical and a New Genotype of Rabbit Haemorrhagic Disease Virus

Vaccines, 2020
Myxoma virus (MV) and rabbit haemorrhagic disease virus (RHDV) are the major causes of lethal viral diseases in the European rabbit. In 2010, a new RHDV genotype (RHDV2) emerged in the field that had limited cross-protection with the classical RHDV ...
Sylvia Reemers, Leon Peeters, Joyce van Schijndel, Beth Bruton, David Sutton, Leo van der Waart, Saskia van de Zande   +6 more
doaj   +1 more source

Parallel adaptation of rabbit populations to myxoma virus. [PDF]

Science, 2019
Locating myxomatosis resistance Myxomatosis is a viral infection that was deliberately introduced from American cottontail rabbits into European rabbit populations to control their population. Over the past 60 years or so, similar resistance variants have emerged in parallel in the United Kingdom, France, and Australia. Alves
Alves JM, Carneiro M, Cheng JY, Lemos de Matos A, Rahman MM, Loog L, Campos PF, Wales N, Eriksson A, Manica A, Strive T, Graham SC, Afonso S, Bell DJ, Belmont L, Day JP, Fuller SJ, Marchandeau S, Palmer WJ, Queney G, Surridge AK, Vieira FG, McFadden G, Nielsen R, Gilbert MTP, Esteves PJ, Ferrand N, Jiggins FM.   +27 more
europepmc   +9 more sources

Detection of myxoma viruses encoding a defective M135R gene from clinical cases of myxomatosis; possible implications for the role of the M135R protein as a virulence factor

Virology Journal, 2010
Background Myxoma virus is a member of the Poxviridae and causes disease in European rabbits. Laboratory confirmation of the clinical disease, which occurs in the autumn of most years in Denmark, has been achieved previously using antigen ELISA and ...
Larsen Lars E, Breum Solvej Ø, Polacek Charlotta, Belsham Graham J, Bøtner Anette   +4 more
doaj   +1 more source

Evidence for differential viral oncolytic efficacy in an in vitro model of epithelial ovarian cancer metastasis

Molecular Therapy: Oncolytics, 2015
Epithelial ovarian cancer is unique among most carcinomas in that metastasis occurs by direct dissemination of malignant cells traversing throughout the intraperitoneal fluid.
Jessica G Tong, Yudith Ramos Valdes, John W Barrett, John C Bell, David Stojdl, Grant McFadden, J Andrea McCart, Gabriel E DiMattia, Trevor G Shepherd   +8 more
doaj   +1 more source