Myxoma Virus and the Leporipoxviruses: An Evolutionary Paradigm
Viruses, 2015 Myxoma virus (MYXV) is the type species of the Leporipoxviruses, a genus of Chordopoxvirinae, double stranded DNA viruses, whose members infect leporids and squirrels, inducing cutaneous fibromas from which virus is mechanically transmitted by biting ...
Peter J. Kerr +5 more
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Oncolytic Virotherapy with Myxoma Virus [PDF]
Journal of Clinical Medicine, 2020 Oncolytic viruses are one of the most promising novel therapeutics for malignant cancers. They selectively infect and kill cancer cells while sparing the normal counterparts, expose cancer- specific antigens and activate the host immune system against both viral and tumor determinants.
Masmudur M Rahman +2 more
exaly +5 more sources
MNF, an ankyrin repeat protein of myxoma virus, is part of a native cellular SCF complex during viral infection [PDF]
Virology Journal, 2010 Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Gelfi Jacqueline +3 more
doaj +2 more sources
Systemic therapy with oncolytic myxoma virus cures established residual multiple myeloma in mice
Molecular Therapy: Oncolytics, 2016 Multiple myeloma is an incurable malignancy of plasma B-cells. Traditional chemotherapeutic regimes often induce initial tumor regression; however, virtually all patients eventually succumb to relapse caused by either reintroduction of disease during ...
Eric Bartee +3 more
doaj +2 more sources
The Complete DNA Sequence of Myxoma Virus
Virology, 1999 Myxomatosis in European rabbits is a severely debilitating disease characterized by profound systemic cellular immunosuppression and a high rate of mortality. The causative agent, myxoma virus, is a member of the poxvirus family and prototype of the Leporipoxvirus genus.
Cameron, Cheryl +8 more
openaire +3 more sources
Myxoma Virus Combination Therapy Enhances Lenalidomide and Bortezomib Treatments for Multiple Myeloma [PDF]
PathogensThis study aimed to explore the effectiveness and safety of Myxoma virus (MYXV) in MM cell lines and primary myeloma cells obtained from patients with multiple myeloma. Myeloma cells were isolated from MM patients and cultured.
Alpay Yeşilaltay +8 more
doaj +2 more sources
Oncolytic Myxoma virus Increases Autophagy in Multiple Myeloma [PDF]
Turkish Journal of HematologyObjective: Multiple myeloma, which affects plasma cells, is the second most common hematological malignancy. Despite the development of new drugs and treatment protocols, patient survival has not reached the desired level.
Alpay Yeşilaltay +2 more
doaj +2 more sources
Virology, 1999 Myxoma virus is a poxvirus that causes a virulent systemic disease called myxomatosis in European rabbits. Like many poxviruses, myxoma virus encodes a variety of secreted proteins that subvert the antiviral activities of host cytokines. It was recently demonstrated that the myxoma virus M-T1 glycoprotein is a member of a large poxvirus family of ...
Lalani, Alshad S. +5 more
openaire +3 more sources
Detection of myxoma virus in the classical form of myxomatosis using an AGID assay: statistical assessment of the assay’s diagnostic performance [PDF]
Journal of Veterinary Research, 2020 The aim of the study was to estimate the diagnostic sensitivity (DSe) and specificity (DSp) of an agar gel immunodiffusion (AGID) assay for detection of myxoma virus (MYXV) in the classical form of myxomatosis and to compare its diagnostic performance to
Kwit Ewa +3 more
doaj +2 more sources
Identification of a Novel Myxoma Virus C7-Like Host Range Factor That Enabled a Species Leap from Rabbits to Hares [PDF]
mBio, 2022 Myxoma virus (MYXV) is naturally found in rabbit Sylvilagus species and is known to cause lethal myxomatosis in European rabbits (Oryctolagus cuniculus).
Ana Águeda-Pinto +13 more
doaj +2 more sources