Results 31 to 40 of about 119,088 (258)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

EUTHANASIA DALAM PERPEKTIF INDONESIA DAN HAM INTERNASIONAL

Justitia Et Pax
The act of euthanasia is a problem that has never been resolved related to the legality of its implementation where many countries have legalized or prohibited the act.
Adela Oktaviani Putri, Lina Hastuti
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Comparison of Indonesian and Dutch Laws on the Implementation of Euthanasia

Al-Adalah
Developments in various matters cannot be separated from the regulations attached to them, one of which is related to euthanasia. Euthanasia in general is a treatment given to a patient to end his life intentionally with the aim of escaping suffering ...
Winda Fitri, Winsherly Tan, Aulia Ginda Putri   +2 more
doaj   +1 more source

Determinants in Opinions Regarding Euthanasia in a Sample of Portuguese Medical Doctors

Revista Iberoamericana de Bioética, 2019
Objectives: This study seeks to establish potential determinants in the opinion of Portuguese physicians on euthanasia, and to verify if a confrontation with concrete scenarios has an effect on this opinion.
Miguel Ricou, Luis Azevedo, Sofia da Silva   +2 more
doaj   +1 more source

Evaluation of Knowledge and Attitudes toward Euthanasia between Physicians and Caregivers

Central Asian Journal of Medical Sciences, 2023
Objective: This study aimed to estimate the knowledge of the legal regulation of euthanasia and painless death among terminally ill patients, their caregivers, and attending physicians.
Sukhbaatar Chuluunsukh, Minjuur Tserenbat, Enkhbat Bayarmaa, Tseren Tuvshinjargal, Tseren Tuvshinjargal   +4 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Attitude of the Nursing and Midwifery Students of Mazandaran University of Medical Sciences towards Euthanasia [PDF]

Preventive Care in Nursing and Midwifery Journal, 2020
Background: Euthanasia has been the most controversial topic for more than 3,000 years and is among important issues in medical ethics in today’s world, having something to do with the value system of human life.
Mina Malary, Mahmood Moosazadeh , Iman Moghaddasifar, Malihe Imeni, Marzieh Faghani Aghoozi, Shadi Sabetghadam, Malihe Amerian   +6 more
doaj  

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source