Results 51 to 60 of about 218,220 (306)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Dairy workers' attitudes toward dairy cattle euthanasia

Journal of Dairy Science, 2023
: Implementing timely and humane euthanasia in dairy farms remains a critical concern. One of the possible barriers for the implementation of timely euthanasia on-farm is dairy workers' attitudes toward the act.
Victoria R. Merenda, Eduardo B. de Oliveira, Magdiel Lopez-Soriano, Andréia G. Arruda, Ashley Robbins, Monique D. Pairis-Garcia   +5 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair

Advanced Healthcare Materials, EarlyView.
An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret, Ryan M. Friedman, Gautham Nair, Stephanie L. Fung, Dana D. Ragbirsingh, John Germiller, Riccardo Gottardi   +6 more
wiley   +1 more source

An argument for physician-assisted suicide and against euthanasia [PDF]

, 2015
The article opens with the hypothesis that the default position that should guide healthcare providers when treating patients at the end-of-life is that patients opt for life. In the absence of an explicit request to die, we may assume that patients wish
Beckford, Bedell, Bernheim, Bilsen, Bilsen, Casarett, Chambaere, Chambaere, Chamber of the Representatives of Belgium, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cook, Cook, Cook, Cook, Culzac, de Diesbach, Delamothe, Deliens, den Hartogh, Gamondi, General Medical Council, Gomez, Haerens, Hardwig, Harris, Hendin, Heneghan, Jochemsen, Keown, Keown, Kuhse, Kuhse, Kuhse, Onwuteaka-Philipsen, Onwuteaka-Philipsen, Pardon, Quebec Bill 52, Schuklenk, Sercu, Sheldon, Singer, Sprung, Steck, Swildens-Rozendaal, van der Heide, van der Heide, van der Heide, van der Wal, Visser   +56 more
core   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Religious Perspectives on Euthanasia: A Comparative Analysis

International Journal of Body, Mind and Culture, 2023
Background: This article argues the various religious views on euthanasia. After that, a comparison will be done to see where euthanasia is permitted or not.
chintu jain, Azimkhan B. Pathan
doaj   +1 more source

How the mass media report social statistics: A case study concerning research on end-of-life decisions [PDF]

, 2010
This is the post-print version of the final paper published in Social Science & Medicine. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural ...
Bauman, Bell, Best, Best, Best, Boyce, Cicourel, Clive Seale, Deacon, Entwistle, Fenton, Fenton, Galtung, Gorer, Harcup, Hausmann, Jackson, Kitzinger, Kitzinger, Kuhse, Langer, Lewis, McInerney, McInerney, McInerney, Mellor, Nelkin, Osborne, Pollock, Rietjens, Schmierbach, Seale, Seale, Seale, Seale, Seale, Seale, Seale, Signorielli, Sparks, Sykes, van der Heide, van der Maas, Wakefield, Williams   +44 more
core   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Why letting die instead of killing? Choosing active euthanasia on moral grounds [PDF]

, 2018
Ever since the debate concerning euthanasia was ignited, the distinction between active and passive euthanasia – or, letting die and killing – has been marked as one of its key issues.
Protopapadakis, Evangelos
core   +1 more source