Results 61 to 70 of about 160,752 (259)
ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief
Advanced Science, EarlyView.ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng +19 more
wiley +1 more source
Euthanasia as a professional dilemma in nursing students
Medisur, 2023 Foundation: the World Health Organization defines euthanasia as the deliberate action carried out by a person with the intention of causing the painless death of another subject, or not preventing death from natural causes, in case of terminal illness or
María Verónica Aveiga Hidalgo +3 more
doaj
Euthanasia, Ethics and Economics
, 1990 The financial aspects of legalizing active euthanasia rarely have been discussed. Hayry and Hayry argue that there are no good grounds for ignoring the connection between euthanasia and the need to conserve medical resources. Their paper is intended to
Hayry, Heta, Hayry, Matti
core +1 more source
Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress
Advanced Science, EarlyView.Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen +11 more
wiley +1 more source
Euthanasia and the Assessment of Patients' Autonomy Rights in the Indonesian Criminal Code
Lentera Hukum, 2020 This study aims to analyze and clarify the application of criminal law principles in cases of euthanasia. The concept of euthanasia is a new thought in criminal law that arises because of humans' desire to determine life's direction.
Fanny Tanuwijaya
doaj +1 more source
Advanced Science, EarlyView.ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning +7 more
wiley +1 more source
, 1995 Many patients are subject to ‘do not resuscitate’ orders or are ‘allowed to die’. The predominant moral position within health care seems to be that this is permissible, while voluntary euthanasia is not. This paper attempts to consider the logic of that
Sellman, Derek
core +1 more source
Advanced Science, EarlyView.ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo +16 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai +11 more
wiley +1 more source
End Games: Euthanasia Under Interminable Scrutiny
, 2005 It is increasingly asserted that the disagreements of abstract principle between adversaries in the euthanasia debate fail to account for the complex, particular and ambiguous experiences of people at the end of their lives.
Parker, Malcolm
core +1 more source