Results 111 to 120 of about 337,152 (297)

The mean density of retinal ganglion cells (MD-RGCs) retrograde labeled by cholera toxin subunit B (CTB) and Fluorogold(FG) at 1 week and 2 weeks in rats.

, 2018
(A) MD-RGCs in CTB-1w (rats euthanized 1 week post-CTB injection) and CTB-2w (rats euthanized 2 weeks post-CTB injection) were less than those in FG-1w (rats euthanized 1 week post-FG injection) and FG-2w (rats euthanized 2 weeks post-FG injection) (p ...
Hongpei Ji (5824256), Zhaolin Gao (5824253), Fei Yao (43685), Endong Zhang (5129969), Mahmoud Marmouri (5824259), Xiaobo Xia (4015217)   +5 more
core   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

The diffusion area of cholera toxin subunit B (CTB) and Fluorogold(FG) in the superior colliculus (SC) at 1 week and 2 weeks in rats.

, 2018
(A) The diffusion area of tracers in the SC (DA-SC) in FG-1w (rats euthanized 1 week post-FG injection) and FG-2w (rats euthanized 2 weeks post-FG injection) were much larger than those in CTB-1w (rats euthanized 1 week post-CTB injection) and CTB-2w ...
Hongpei Ji (5824256), Zhaolin Gao (5824253), Fei Yao (43685), Endong Zhang (5129969), Mahmoud Marmouri (5824259), Xiaobo Xia (4015217)   +5 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Number of positive RT PCR tests of swab samples during the trial; total test amount 29 G: T. graeca; H: T. hermanni; 1–10: Number of single animal; dpi: Days post inoculation Red: Positive; Green: Negative; Black: Not tested Last column presents positive results of total testing (29) in each animal, to show the high number of positive tests in early euthanized animals.

, 2019
Number of positive RT PCR tests of swab samples during the trial; total test amount 29 G: T. graeca; H: T. hermanni; 1–10: Number of single animal; dpi: Days post inoculation Red: Positive; Green: Negative; Black: Not tested Last column presents positive
M. Lierz (6376958), K. Failing (6376955), S. Paries (6376946), S. Funcke (6376949), O. Kershaw (6376952)   +4 more
core   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Experimental study of histological changes in vascular loops according to the duration of the postoperative period: Application in reconstructive microsurgery

Clinics
OBJECTIVES: To analyze the histological changes observed in venous grafts subjected to arterial blood flow as a function of the duration of the postoperative period to optimize their use in free flap reconstructions.
Renata Gregorio Paulos, Bruno Alves Rudelli, Renee Zon Filippe, Gustavo Bispo dos Santos, Ana Abarca Herrera, Andre Araujo Ribeiro, Marcelo Rosa de Rezende, Teng Hsiang-Wei, Rames Mattar-Jr   +8 more
doaj   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Supplemental Fig. S1

, 2019
Figure S1. Experimental design. First: all mice were submitted to adaptation protocol and randomly allocated in the experimental or control group. The control groups did not carry out any exercise procedures.
André Minari (6934577)
core   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source