Results 91 to 100 of about 337,152 (297)

Number of lactating dams.

, 2021
*One mouse dead during shipment from Jackson laboratories, **One mouse found dead or euthanized due to dermal injuries during the study, ***Three mice found dead or euthanized due to dermal injuries at various times during the study. (DOCX)
Willard M. Freeman (11502396), Jordan Jackson (11502387), Michael B. Stout (10731299), Michelle Ranjo-Bishop (11502393), Kavitha Kurup (11502381), Stephanie Matyi (11502390), Archana Unnikrishnan (3494885), Arlan Richardson (194869), Shivani N. Mann (11502384)   +8 more
core   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Pilot study, field voles that had died from or were euthanized after experimental F. tularensis sp. holartica infection.

, 2014
A, B. Spleen from an animal found dead on day 5 after subcutaneous (s.c.) infection with a low dose (LD). Clumps of bacteria are found cell-free and within (degenerating) macrophages in the red pulp, often surrounding follicles (F).
Olli Vapalahti (87344), Kristian M. Forbes (534137), Paula M. Kinnunen (637549), Simo Nikkari (637551), Anja Kipar (87443), Eveliina Tarkka (511345), Heikki Henttonen (87343), Heidi Rossow (637548), Otso Huitu (366033), Heidi Hemmilä (637550)   +9 more
core   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Avian Sleep Homeostasis: Electrophysiological, Molecular and Evolutionary Approaches [PDF]

, 2011
The function of slow wave sleep (SWS) and rapid eye movement (REM) sleep in mammals is an unanswered question in neuroscience. Aside from mammals, only birds engage in these states.
Lesku, John
core   +1 more source

Can a physician ever justifiably euthanize a severely disabled neonate? [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2015
Physician-assisted suicide has been legalized in 3 states (Oregon and Washington by public referendum and Vermont by legislation) and has been judicially sanctioned in 2 others (Montana and New Mexico)1; it is illegal in the remaining 45 states. In assisted suicide, the assister is passively involved in causing death; in euthanasia, a person actively ...
openaire   +2 more sources

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Do bank voles (Myodes glareolus) trapped in live and lethal traps show differences in tick burden?

PLoS ONE, 2020
In studies assessing tick abundance, the use of live traps to capture and euthanize rodent hosts is a commonly used method to determine their burden.
Nicolas De Pelsmaeker, Lars Korslund, Øyvind Steifetten   +2 more
doaj   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Cilnidipine Alleviates Alpha‑naphthyl isothiocyanate -Induced Cholestasis in Rats

Iraqi Journal of Pharmaceutical Sciences
Cholestasis is defined as a reduction or stagnation in bile secretion and flow. Inflammation results from blocked bile that leaks into the bloodstream and accumulates in the organs.
Thamer Abdulla Mohammed , Munaf H. Zalzala   +1 more
doaj   +1 more source