Results 81 to 90 of about 337,152 (297)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Financial and welfare implications of immediately euthanizing compromised nursery pigs

Journal of Swine Health and Production, 2006
Objective: To provide economic and welfare information necessary to determine if a compromised pig should be euthanized or provided continued care. Methods: We assigned batches of pigs to protocols that required many, some, or few compromised pigs to be euthanized upon entering the nursery (aggressive, moderate, or conservative euthanasia protocols ...
Morgan Morrow, Robert Meyer, John Roberts, Duncan Lascelles   +3 more
openaire   +1 more source

Viral antigen expression in tissues of selected chickens that were euthanized at humane endpoint.

(A) Degree of viral antigen expression in tissues of a chicken mono-inoculated with ~104 EID50 H7N7-HPHAtag and euthanized at humane endpoint at 4 dpi (A) and a chicken co-inoculated with H7N7-LPFLAGtag/H7N7-HPHAtag and euthanized at humane endpoint at 3
Mathis Funk (18056488), Dennis de Meulder (14774383), Lonneke M. Leijten (18056491), Theo M. Bestebroer (7538081), Debby van Riel (344327), Stefan van Nieuwkoop (12065983), Ron A. M. Fouchier (7538084), Pascal Lexmond (74807), Monique I. Spronken (18056479), Mathilde Richard (168469), Miruna E. Rosu (18056485), Sander Herfst (327462), Anja C. M. de Bruin (18056476), Adinda Kok (18056482)   +13 more
core   +1 more source

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Nannizziopsis arthrosporioides infection mimicking ophidiomycosis in ball pythons (Python regius)

Medical Mycology Case Reports
A wild caught snake presented with progressive dermatopathy and was euthanized due to a clinical suspicion for ophiomycosis. Over the next 7 days, six additional ball pythons, maintained in the same room but in separate cages from the index case ...
Krista A. Keller, Laura Adamovicz, Cathy Johnson-Delaney, Karen A. Terio   +3 more
doaj   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Evaluation of nociception and edema in experimental sciatic nerve compression model in Wistar rats treated with cryotherapy

Revista Dor
BACKGROUND AND OBJECTIVES: Considering the scarcity of studies addressing cryotherapy to treat peripheral nervous injuries, this study aimed at evaluating nociception and edema in an experimental sciatic nerve compression model with Wistar rats treated ...
Jhenifer Karvat, Camila Mayumi Martin Kakihata, Lizyana Vieira, Juliana Sobral Antunes, Lucinéia de Fátima Chasko Ribeiro, Gladson Ricardo Flor Bertolini   +5 more
doaj   +1 more source

Landscape review about the decision to euthanize a compromised pig

Porcine Health Management
AbstractTimely euthanasia of a compromised pig in farming practice has been identified as a critical topic in veterinary medicine. The questions ‘why and when are pigs euthanized’ and ‘what influences the decision making process’ need to be answered to improve the situation. In the past five years, work addressing these issues has been published in the
J. Stoffregen, T. Winkelmann, B. Schneider, K. Gerdes, M. Miller, J. Reinmold, C. Kleinsorgen, K. H. Toelle, L. Kreienbrock, E. grosse Beilage   +9 more
openaire   +3 more sources

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Photovoltaic Stimulation of Mouse and Pig Retina With Pyrolytic Carbon Microelectrodes Integrated on High‐Density Silicon Solar Cell Arrays

Advanced Healthcare Materials, EarlyView.
In this study, we fabricate photovoltaic retinal implants with pyrolytic carbon electrodes and test their ability to stimulate mouse and pig retinas when illuminated with near‐infrared light. We find increased spiking activity in both animal models compared to spontaneous activity and TTX controls and analyze the spike amplitude, latency and frequency.
Akihiro Matsumoto, Pratik Kusumanchi, Jesper Guldsmed Madsen, Asbjørn Cortnum Jørgensen, Gisele Alves dos Reis Benatto, Sune Thorsteinsson, Peter Behrensdorff Poulsen, Keisuke Yonehara, Toke Bek, Stephan Sylvest Keller, Rasmus Schmidt Davidsen   +10 more
wiley   +1 more source