Results 101 to 110 of about 337,152 (297)

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

open access: yesAdvanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte   +21 more
wiley   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

open access: yesAdvanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian   +7 more
wiley   +1 more source

Nutritional myodegeneration as a cause of dysphagia in adult horses: three case reports

open access: yesVeterinární Medicína, 2007
Three cases of nutritional myodegeneration caused by selenium deficiency in adult horses are described. Difficulty in eating and drinking was a common clinical sign in all horses.
E. Ludvikova, P. Jahn, Z. Lukas
doaj   +1 more source

Photoacoustic Nanotagging for In Vivo Tracking and Optimization of Macrophage Immunotherapy in Solid Tumors

open access: yesAdvanced Materials, EarlyView.
Macrophage‐based immunotherapy for solid tumors is limited by poor tracking of cell localization and persistence. This study introduces nanotagged macrophages enabling near‐infrared photoacoustic imaging for real‐time monitoring. IFNγ‐conjugated tags enhance antitumor polarization without harming viability.
Seoyoon Song   +8 more
wiley   +1 more source

Transforming Kern's relationship with unwanted animals: are programs operated by county animal control effective in reducing the rate of animals euthanized? [PDF]

open access: yes, 2011
A 2004 article in the Bakersfield Californian detailed the relationship the community of Kern County had with what the writer calls “throw away” animals. A subsequent series of articles revealed approximately 25,000 animals were being killed in the local
Guest, Suzanne B
core  

Ionic Gating of Liquid‐Crystal‐Like Pteridine Assemblies Enables Tunable Light Scattering

open access: yesAdvanced Materials, EarlyView.
Tunable optical properties emerge through developmentally regulated ionic gating, which transforms disordered, ultraviolet (UV)‐absorbing organelles into concentrically ordered, liquid‐crystal‐like light scatterers. By integrating analyses of pteridine composition, potassium‐dependent assembly, hierarchical ultrastructure, and optical behavior, the ...
Sourabh Bera   +22 more
wiley   +1 more source

Arthropod Succession in Rats Euthanized with Carbon Dioxide and Sodium Pentobarbital

open access: yes, 1995
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Patrican, Lisa A, Vaidyanathan, Rajeev
openaire   +2 more sources

The characteristics of optic nerves retrograde labeled using cholera toxin subunit B (CTB) and Fluorogold(FG) at 1 week and 2 weeks in rats.

open access: yes, 2018
The optic nerves labeled using CTB were much clearer than those labeled using FG. CTB-1w, rats euthanized 1 week post-CTB injection; CTB-2w, rats euthanized 2 weeks post-CTB injection; FG-1w, rats euthanized 1 week post-FG injection; FG-2w, rats ...
Hongpei Ji (5824256)   +5 more
core   +1 more source

ChicGrasp: Imitation‐Learning‐Based Customized Dual‐Jaw Gripper Control for Manipulation of Delicate, Irregular Bio‐Products

open access: yesAdvanced Robotics Research, EarlyView.
Automated poultry processing lines still rely on humans to lift slippery, easily bruised carcasses onto a shackle conveyor. Deformability, anatomical variance, and hygiene rules make conventional suction and scripted motions unreliable. We present ChicGrasp, an end‐to‐end hardware‐software co‐designed imitation learning framework, to offer a ...
Amirreza Davar   +8 more
wiley   +1 more source

The Anti-Inflammatory Effect of Chromium Picolinate in Doxorubicin Induced Cardiotoxicity in Rats

open access: yesIraqi Journal of Pharmaceutical Sciences
Doxorubicin is a potent anthracycline antibiotic used to treat many types of human neoplasms. The long-term adverse effect is cardiomyopathy, which is primarily caused by the extensive production of reactive oxygen species, which relates to several ...
Asmaa Muhammad Khalifa   +1 more
doaj   +1 more source

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