Results 81 to 90 of about 294,494 (258)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Military Routine in Rear City in 1941–1945 (Case of Alma-Ata)

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2020
Introduction. The purpose of this article is to highlight the features of daily life in cities of rearguard during World War II (as exemplified by Alma-Ata), the strategy of survival of people in the extremely difficult war years (1941–1945).
Roza S. Zharkynbayeva, Nadezhda V. Dulina, Evgeniya V. Anufrieva   +2 more
doaj   +1 more source

Development Of Planning Support System For Urban Rehabilitation And Reconstruction In Case Sidoarjo Mud Flow Post Disaster [PDF]

, 2011
Sidoarjo mud disaster impact that has lasted more than 3 years are very influential on other aspects of life in Porong and surrounding areas. The need for information systems that can inform the public about the catastrophic conditions is absolutely ...
Arna, Fariza, M. Syamsul, Hudha, Muhamad, Bayu AS, Rosita, Vebriesti Ratri, Wahjoe, Tjatur Sesulihatien   +4 more
core  

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Cloud Enabled Emergency Navigation Using Faster-than-real-time Simulation

, 2015
State-of-the-art emergency navigation approaches are designed to evacuate civilians during a disaster based on real-time decisions using a pre-defined algorithm and live sensory data.
Bi, Huibo, Gelenbe, Erol
core   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Ship design with the human factor: evacuation and normal operations modelling in the ship design process [PDF]

, 2012
This thesis addresses the modelling of human factors and how they can impact ship design. Two different but related applications areas are considered; passenger ship evacuation analysis and naval vessel normal operations and evacuation analysis.
Deere, Steven John
core  

Modeling pedestrian evacuation movement in a swaying ship

, 2015
With the advance in living standard, cruise travel has been rapidly expanding around the world in recent years. The transportation of passengers in water has also made a rapid development.
AH Olivier, AI Ginnis, D Helbing, ER Galea, J Ma, W Daamen   +5 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source