Results 181 to 190 of about 1,484 (240)

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Evading the law.

Minnesota medicine, 2007
openaire   +1 more source

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An optimal evader strategy in a two-pursuer one-evader problem

53rd IEEE Conference on Decision and Control, 2014
We consider a relay pursuit-evasion problem with two pursuers and one evader. We reduce the problem to a one-pursuer/one-evader problem subject to a state constraint. A suboptimal control strategy for the evader to prolong capture is proposed and is compared to the optimal evading strategy.
Panagiotis Tsiotras
exaly   +3 more sources

Multi-player pursuit–evasion games with one superior evader [PDF]

Automatica, 2016
Inspired by the hunting and foraging behaviors of group predators, this paper addresses a class of multi-player pursuit–evasion games with one superior evader, who moves faster than the pursuers.
Dongbing Gu, Wenzhong Zha
exaly   +2 more sources

To evade taxes or not to evade: that is the question

The Journal of Socio-Economics, 2003
Abstract Tax evasion seems to be a growing problem in almost all countries. The paper analyses the possibilities and limitations of game-theoretical aspects to analyse tax evasion. However, empirical findings indicate that most people pay more taxes than the traditional economic approach would predict.
openaire   +1 more source

3-D Multi-player Pursuit-evasion Game with a Faster Evader

, 2020
This paper studies two kinds of multi-player pursuit-evasion games in 3-D space: Two-pursuer one-evader game and multi-pursuer one-evader game. The main challenges are that the evader has faster speed than a group of pursuers and the moving directions of
Xu Fang, Lihua Xie
exaly   +2 more sources

A decentralized approach to pursuer-evader games with multiple superior evaders

2006 IEEE Intelligent Transportation Systems Conference, 2006
Few approaches dealing with pursuer-evader (PE) game allow real-time applications for multi-pursuer-multi-evader situations, especially for cases of evaders with superior control resources such as higher speeds. In addition, existing implementations are often centralized and require prohibitive computation even for very small-scale case.
Mo Wei, Genshe Chen, Jose B. Cruz Jr., L. Hayes, Mou-Hsiung Chang   +4 more
openaire   +2 more sources

Evading Justice

Criminal Justice and Behavior, 2013
The “successful psychopath” is thought to evade scientific study because most forensic psychopathy research is limited to incarcerated—putatively unsuccessful—samples. By redefining criminal success as the proportion of past undetected crimes, the present study tested the hypothesis that psychopathic traits are associated with criminal success within ...
Eyal Aharoni, Kent A. Kiehl
openaire   +1 more source