Results 91 to 100 of about 2,034,522 (291)

Advancing the implementation of evidence-based substance use prevention in Latin America: the Evidencia Viva program registry

open access: yesRevista Panamericana de Salud Pública
Evidence-based program registries (EBPRs) are essential tools in prevention science, providing structured evaluations of intervention effectiveness to guide policymakers and practitioners. While established registries such as Blueprints for Healthy Youth
Zila M. Sanchez   +4 more
doaj   +1 more source

Evaluation of the efficacy of bleomycin encapsulated within liposomes as novel, topical treatment for skin cancer in veterinary species and its potential for human medicine: an in vitro, ex vivo and in vivo study

open access: yes, 2020
Bleomycin is a potent anticancer agent that is able to induce single and double stranded breaks in DNA. It is effective against several types of cancer, including cutaneous skin tumours, in both human and veterinary medicine. However, due to its molecular characteristics, including polar charge and high molecular weight, it is unable to effectively ...
openaire   +3 more sources

Sowing and reaping: institutional quality and project outcomes in developing countries [PDF]

open access: yes
Much of the academic debate on the effectiveness of foreign aid is centered on the relationship between aid and growth. Different aid-growth studies find conflicting results: aid promotes growth everywhere; aid has a zero or negative impact on growth ...
Dollar, David, Levin, Victoria
core  

Auditing Search Engines for Differential Satisfaction Across Demographics [PDF]

open access: yes, 2017
Many online services, such as search engines, social media platforms, and digital marketplaces, are advertised as being available to any user, regardless of their age, gender, or other demographic factors.
Anderson, Ashton   +5 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Improvement of Educational Products Validation form in professional postgraduate programs

open access: yesRevista Brasileira de Enfermagem
Educational Product and Technical-Technological Product constitute a specificity of postgraduate programs in the professional modality, a product that must be carefully evaluated by the programs and recorded on platforms of evaluating bodies.
Karina Franco Zihlmann   +1 more
doaj   +2 more sources

Strategic Environmental Consideration of Nuclear Power Through Comparative Evaluation of Energy Options

open access: yesChemical Engineering Transactions, 2013
The key topic of the paper is comparative evaluation of various energy options. It is treated from the strategic planning and assessment points of view and is supported by a discussion of multi-objective decision making.
B. Kontic
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Educational Technology Topic Guide [PDF]

open access: yes, 2014
This guide aims to contribute to what we know about the relationship between educational technology (edtech) and educational outcomes by addressing the following overarching question: What is the evidence that the use of edtech, by teachers or students ...
Gater, Rosalind   +3 more
core  

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