Results 111 to 120 of about 487,300 (314)

QUADAS e STARD: avaliação da qualidade de estudos de acurácia de testes diagnósticos

Revista de Saúde Pública
OBJETIVO: Comparar duas abordagens baseadas em critérios do Quality Assessment of Diagnostic Accuracy Studies (QUADAS) e do Standards for Reporting Studies of Diagnostic Accuracy (STARD) na avaliação de qualidade de estudos de validação do teste rápido ...
Maria Regina Fernandes de Oliveira, Almério de Castro Gomes, Cristiana Maria Toscano   +2 more
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Trustworthiness evaluation in recommendation seeking behavior

, 2019
Recommendations often play a key role in making routine daily decisions or consuming a variety of information, and therefore, recommender systems (RSs) that evaluate, filter, and deliver personalized information are becoming increasingly important ...

core   +1 more source

Evaluation of topical metronidazole in the healing wounds process: an experimental study.

Revista do Colegio Brasileiro de Cirurgioes, 2011
To assess the efficacy of a topical 4% metronidazole solution in wound healing by secondary intention in rats.We made circular wounds two inches in diameter at the back of rats and studied healing at 3, 7, 14 and 21 days. The wound contraction and epithelialization were assessed by peripheral digital planimetry and myofibroblasts by ...
Lilian Cristine Teixeira, Trindade, Maria de Lourdes Pessole, Biondo-Simões, Cláudia Paraguaçu Pupo, Sampaio, Rogério Estevam, Farias, Rodrigo Jardim, Pierin, Miguel Chomiski, Netto   +5 more
openaire   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

A case study in the evaluation of English training courses using a version of the CIPP model as an evaluative tool [PDF]

, 2009
This thesis presents an evaluative case study of the 20 English training courses offered in the Applied English Department (AED) of an Institute, given the pseudonym W.G, in southern Taiwan.
Chen, Chun-Fu
core  

The current landscape of television and movies in medical education

Perspectives on Medical Education, 2015
Background Using commercially available television and movies is a potentially effective tool to foster humanistic, compassionate and person-centred orientations in medical students.
Marcus Law, Wilson Kwong, Farah Friesen, Paula Veinot, Stella L. Ng   +4 more
doaj   +1 more source