Results 121 to 130 of about 2,034,522 (291)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Pork Managers' Perception of Labor Management Practices and Their Risks [PDF]
Although managing labor has become important for farm operations success, training and education for farm managers focuses on agricultural production management and few studies provide an empirical basis on how agricultural labor management differs from ...
Bitsch, Vera, Olynk, Nicole J.
core +1 more source
Overview of the personalized and collaborative information retrieval (PIR) track at FIRE-2011 [PDF]
, 2011 The Personalized and collaborative Information Retrieval (PIR) track at FIRE 2011 was organized with an aim to extend standard information retrieval (IR) ad-hoc test collection design to facilitate research on personalized and collaborative IR by ...
Curtis, Keith +4 more
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Teachers' knowledge on the development of final evaluation tests
EdumecentroBackground: the development of evaluation tests requires methodological work and the consequent preparation of teachers. Objective: determine the level of knowledge of teachers about the preparation of the final evaluation tests for the subject Human ...
Daimaris Rivas Vázquez +5 more
doaj
Humanidades Médicas, 2011 Este artículo de revisión aborda la temática de la evaluación del impacto de los resultados de la ciencia y la innovación en el desarrollo social, como un elemento indispensable para conocer el cumplimiento de las políticas sociales en ciencia y ...
Jorge Lozano Casanova +2 more
doaj
Systematic Literature Review of Topic Labeling
IEEE AccessThe rapid growth of textual data on the web has led researchers to develop methods in Natural Language Processing (NLP) to process, understand, and identify topics.
Salma Mekaoui +3 more
doaj +1 more source
Public Integrity, Economic Freedom and Governance Performance. A Comparative Study for the EU Member States and Acceding Countries [PDF]
, 2010 The studies concerning the impact of corruption on the effectiveness of governance are numerous, valorising profound approaches, based on criteria and standards related to good governance, organizational behaviour.
Matei, Ani, Savulescu, Carmen.
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source