Results 131 to 140 of about 2,034,522 (291)

A Broad Evaluation of the Tor English Content Ecosystem

open access: yes, 2019
Tor is among most well-known dark net in the world. It has noble uses, including as a platform for free speech and information dissemination under the guise of true anonymity, but may be culturally better known as a conduit for criminal activity and as a
Allahyari, Mehdi   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Recent Advancements in Topic Modeling Techniques for Healthcare, Bioinformatics, and Other Potential Applications

open access: yesAdvanced Intelligent Systems
In today's era of enormous text data, topic modeling is emerging as a revolutionary tool in natural language processing. From the corpus of scientific research articles to social media posts and newspaper headlines, topic modeling is employed in several ...
Pratima Kumari   +6 more
doaj   +1 more source

Graduate Catalog, 2004-2005 [PDF]

open access: yes, 2004
https://scholar.valpo.edu/gradcatalogs/1031/thumbnail ...
Valparaiso University
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Simulation technology use in disaster medicine education and training: a scoping review

open access: yesFrontiers in Disaster and Emergency Medicine
BackgroundDisaster medicine (DM) education has increasingly turned to simulation technologies to address the limitations of traditional training methods.
José García Ulerio   +10 more
doaj   +1 more source

Optimization of stand-alone photovoltaic system by implementing fuzzy logic MPPT controller [PDF]

open access: yes, 2013
A photovoltaic (PV) generator is a nonlinear device having insolation-dependent volt-ampere characteristics. Since the maximum-power point varies with solar insolation, it is difficult to achieve an optimum matching that is valid for all insolation
Hashim, Mokhtar
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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