Results 131 to 140 of about 487,300 (314)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Linking knowledge transformation to information systems evaluation

open access: yes, 2005
The evaluation and assessment of information systems (IS) is rapidly becoming an important and significant topic for study as well as practice. As such, the application of appraisal frameworks within technology management scenarios in industrial ...
Sharif, AM   +5 more
core   +1 more source

Evaluating the efficacy of topical steroids in idiopathic granulomatous mastitis: a prospective cohort study

open access: yesGland Surgery
Oral steroids are recommended as the first-line treatment for idiopathic granulomatous mastitis (IGM), but frequently induce significant side effects. Topical steroid therapy has recently emerged as a potential alternative for IGM, however current evidence regarding the efficacy of topical steroids remains scarce, primarily derived from small case ...
Lin, Weiyi   +6 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Evaluating Impact

open access: yes, 2014
Lecture presentations hosted by the College of Nursing featuring faculty, graduate students, nursing professionals, and allied health experts. Each lunchtime lecture is devoted to a timely topic examining the training, research and scholarly needs of the
Shipman, Jean P.; Wimmer Erin
core  

Designing for learning and support: The user-centred construction and evaluation of an on-line environment for Malaysian teachers learning about digital graphics [PDF]

open access: yes, 2008
This research focused on the importance of user context in designing learning and support in an online learning environment since the increase of the use of online learning environment had produced several problems and perceptions among students ...
Yahaya, Noraffandy
core  

Recent Advancements in Topic Modeling Techniques for Healthcare, Bioinformatics, and Other Potential Applications

open access: yesAdvanced Intelligent Systems
In today's era of enormous text data, topic modeling is emerging as a revolutionary tool in natural language processing. From the corpus of scientific research articles to social media posts and newspaper headlines, topic modeling is employed in several ...
Pratima Kumari   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Simulation technology use in disaster medicine education and training: a scoping review

open access: yesFrontiers in Disaster and Emergency Medicine
BackgroundDisaster medicine (DM) education has increasingly turned to simulation technologies to address the limitations of traditional training methods.
José García Ulerio   +10 more
doaj   +1 more source

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