Results 141 to 150 of about 2,132,852 (328)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Systematic Literature Review of Topic Labeling
IEEE AccessThe rapid growth of textual data on the web has led researchers to develop methods in Natural Language Processing (NLP) to process, understand, and identify topics.
Salma Mekaoui +3 more
doaj +1 more source
A survey of recent methods on deriving topics from Twitter: algorithm to evaluation
Knowledge and Information Systems, 2020 Robertus Nugroho +4 more
semanticscholar +1 more source
Cross-Cultural Analysiis of European e-Government Adoption [PDF]
In terms of adoption, the topic of e-government has focused on the supply side (or government-related issues) such as strategies and policy, challenges, technical issues, evaluation of the usability of e-government Websites; however, less attention has ...
Aykut, Arslan
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Advanced Intelligent SystemsIn today's era of enormous text data, topic modeling is emerging as a revolutionary tool in natural language processing. From the corpus of scientific research articles to social media posts and newspaper headlines, topic modeling is employed in several ...
Pratima Kumari +6 more
doaj +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source