Results 11 to 20 of about 305,125 (284)

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

Cell, 2022
The SARS-CoV-2 Omicron variant continues to evolve, with new BQ and XBB subvariants now rapidly expanding in Europe/US and Asia, respectively. As these new subvariants have additional spike mutations, they may possess altered antibody evasion properties.
Qian Wang, S. Iketani, Zhiteng Li, Liyuan Liu, Yicheng Guo, Yiming Huang, Anthony D. Bowen, Michael Liu, Maple Wang, Jian Yu, Riccardo Valdez, A. Lauring, Zizhang Sheng, Harris H. Wang, A. Gordon, Lihong Liu, D. Ho   +16 more
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Antibody evasion properties of SARS-CoV-2 Omicron sublineages

Nature, 2022
The identification of the Omicron (B.1.1.529.1 or BA.1) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Botswana in November 20211 immediately caused concern owing to the number of alterations in the spike glycoprotein that ...
S. Iketani, Lihong Liu, Yicheng Guo, Liyuan Liu, J. Chan, Yiming Huang, Maple Wang, Yang Luo, Jian Yu, Hin Chu, K. Chik, T. T. Yuen, M. Yin, Magdalena E. Sobieszczyk, Yaoxing Huang, K. Yuen, Harris H. Wang, Zizhang Sheng, D. Ho   +18 more
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SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Nature, 2021
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B ...
P. Mlcochova, S. Kemp, M. S. Dhar, G. Papa, B. Meng, I. Ferreira, R. Datir, D. Collier, Anna Albecka, S. Singh, R. Pandey, Jonathan C. Brown, Jie Zhou, Niluka Goonawardane, Swapnil Mishra, C. Whittaker, T. Mellan, Robin Marwal, Meena Datta, S. Sengupta, Kalaiarasan Ponnusamy, V. Radhakrishnan, A. Abdullahi, O. Charles, P. Chattopadhyay, P. Devi, D. Caputo, T. Peacock, Dr Chand Wattal, N. Goel, A. Satwik, Raju Vaishya, Meenakshi Agarwal, Antranik Mavousian, J. Lee, J. Bassi, Chiara Silacci-Fegni, C. Saliba, D. Pinto, T. Irie, I. Yoshida, W. Hamilton, Kei Sato, S. Bhatt, S. Flaxman, L. James, D. Corti, L. Piccoli, W. Barclay, P. Rakshit, Anurag Agrawal, Ravindra K. Gupta   +51 more
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SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

Science, 2022
The newly reported Omicron variant is poised to replace Delta as the most prevalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo–electron microscopy (cryo-EM) structural analysis of the Omicron variant spike
D. Mannar, J. Saville, Xing Zhu, S. S. Srivastava, A. Berezuk, Katharine S. Tuttle, A. Márquez, Inna Sekirov, S. Subramaniam   +8 more
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Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma

Frontiers in Immunology, 2023
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is the third leading cause of tumor-related mortality worldwide. In recent years, the emergency of immune checkpoint inhibitor (ICI) has revolutionized the management of HCC ...
Chen Chen, Zehua Wang, Y. Ding, Yanru Qin   +3 more
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Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα.

Cell Metabolism, 2022
High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However, whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is unknown.
Dong Guo, Y. Tong, Xiaoming Jiang, Ying Meng, Hongfei Jiang, Linyong Du, Qingang Wu, Shan Li, Shudi Luo, Min Li, Liwei Xiao, Haiyan He, Xuxiao He, Qiujing Yu, Jing Fang, Zhimin Lu   +15 more
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Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

Science, 2022
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern evades antibody-mediated immunity that comes from vaccination or infection with earlier variants due to accumulation of numerous spike mutations.
M. McCallum, N. Czudnochowski, Laura E. Rosen, Samantha K. Zepeda, John E. Bowen, A. Walls, Kevin Hauser, Anshu Joshi, Cameron Stewart, J. Dillen, Abigail E. Powell, T. I. Croll, Jay C. Nix, Herbert W. Virgin, Davide Corti, G. Snell, D. Veesler   +16 more
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Immune evasion and provocation by Mycobacterium tuberculosis

Nature Reviews Microbiology, 2022
Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host immune response and be transmitted to uninfected individuals.
P. Chandra, Steven J. Grigsby, J. Philips   +2 more
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Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron

Cell, 2022
The SARS-CoV-2 Omicron with increased fitness is spreading rapidly worldwide. Analysis of cryo-EM structures of the Spike (S) from Omicron reveals amino acid substitutions forging interactions that stably maintain an active conformation for receptor ...
Zhen Cui, Pan Liu, Nan Wang, Lei Wang, Kaiyue Fan, Qianhui Zhu, Kang Wang, Ruihong Chen, Rui Feng, Zijing Jia, Minnan Yang, Ge Xu, Boling Zhu, Wangjun Fu, Tian-jiang Chu, Lei Feng, Yide Wang, Xin-Guo Pei, Peng Yang, X. Xie, Lei Cao, Yunlong Cao, Xiangxi Wang   +22 more
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SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies

Nature Reviews Microbiology, 2022
Monoclonal antibodies (mAbs) offer a treatment option for individuals with severe COVID-19 and are especially important in high-risk individuals where vaccination is not an option. Given the importance of understanding the evolution of resistance to mAbs
MacGregor Cox, T. Peacock, William T. Harvey, J. Hughes, Derek W. Wright, B. Willett, E. Thomson, Ravindra K. Gupta, S. Peacock, David L. Robertson, A. Carabelli   +10 more
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