Results 61 to 70 of about 246,024 (234)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
La planificación tributaria internacional. The international tax planning
Retos, 2012 La planificación tributaria internacional se ha desarrollado fundamentada en la globalización y tiene su principal asidero en los múltiples beneficios que el propio legislador ha incorporado en la legislación, en su afán de atraer a los países inversión ...
Romeo Carpio Rivera
doaj +1 more source
Teaching legal ethics at the open university – avoiding the pitfalls of formalism [PDF]
, 2015 This paper will reflect on some of the pedagogical and philosophical issues that arise when teaching ethics to law students. It will begin by explaining the demands made by the legal professional bodies regarding the teaching of legal ethics in England ...
McFaul, Hugh
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
La elección de la forma de explotación agrícola con costes de transacción [PDF]
, 1991 This paper intends to generalize the SANDMO'S model on evasion and optimal taxation (Journal of Public Economics, 1981, Vol. 16) in two directions.
Datta, Samar K. +2 more
core +5 more sources
POLÍTICAS DE DISUASIÓN ÓPTIMA EN LA EVASIÓN FISCAL. CONTRASTACIÓN EMPÍRICA [PDF]
Los trabajos precedentes sobre disuasión óptima de la evasión fiscal tratan sobre los efectos que en la decisión de evadir puedan tener las actuaciones de la Administración Tributaria hasta el momento de la detección y suponen, con mucha frecuencia, que ...
Juan Carlos Gamazo Chillón +1 more
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Los métodos para medir la evasión de impuestos: una revisión [PDF]
, 2007 La presencia del déficit fiscal en Colombia hace necesario que se estudien alternativas diferentesa la de controlar el gasto. Este trabajo hace un recorrido por las principales investigacionesque se han realizado en varias regiones del mundo, pero ...
Agudelo Henao, Luis Fernando +2 more
core +1 more source