Results 121 to 130 of about 45,933 (222)

Clinical Outcomes of Antrectomy for Patients With Multiple Type I Gastric Neuroendocrine Tumors: A Case Series

DEN Open, Volume 7, Issue 1, April 2027.
Type I gastric neuroendocrine tumors (T1‑GNETs) often present as multiple lesions, complicating treatment. This retrospective case series study evaluates antrectomy outcomes in eight patients with persistent multiple T1‑GNETs during 2005–2023. Following antrectomy, tumor regression was observed in two patients and complete disappearance in six, with ...
Yuki Morita, Ken Namikawa, Kaoru Nakano, Wataru Kurihara, Hiroyuki Yamamoto, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Souya Nunobe, Toshiaki Hirasawa   +9 more
wiley   +1 more source

Cost-effectiveness comparison of cabozantinib with everolimus, axitinib, and nivolumab in the treatment of advanced renal cell carcinoma following the failure of prior therapy in England

, 2018
Jie Meng,1 Johanna Lister,1 Anne-Lise Vataire,2 Roman Casciano,1 Jerome Dinet2 1Analytica Laser, London, UK; 2Ipsen Pharma, Boulogne-Billancourt, France Purpose: The aim of this study was to compare the cost-effectiveness of cabozantinib with the ...
Dinet J, Lister J, Vataire AL, Casciano R, Meng J   +4 more
core  

Sleep Disturbances in Adults With Tuberous Sclerosis Complex: Influences of Treatment and Clinical Features

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2454-2463, November 2026.
ABSTRACT Tuberous sclerosis complex (TSC) is a genetic condition with multisystem neurocutaneous signs, including hamartomas, epilepsy, and neuropsychological difficulties. Although sleep disorders are increasingly recognized in TSC, they remain poorly described in adults.
Kirstin A. Risgaard, Laura Farach, Hope Northrup, Sarah L. Wilson, Deborah Pearson, Syed Hashmi, Kate Richardson   +6 more
wiley   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, Volume 13, Issue 56, 9 October 2026.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Serial ctDNA Analysis for Monitoring Molecular Response and Acquired Resistance in Metastatic NSCLC and HR+/HER2‐Negative Breast Cancer: A Real‐World Study

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Circulating tumor DNA (ctDNA) is a promising biomarker for disease monitoring, yet evidence of its clinical utility in routine care remains limited. We evaluated the utility of serial ctDNA monitoring using digital PCR (ddPCR) for detecting acquired resistance (AR) and monitoring response in metastatic non‐small cell lung cancer (NSCLC) and ...
Franciele Hinterholz Knebel, Maurício Fernando Silva Almeida Ribeiro, Rudinei Diogo Marques Linck, Isabela Flauzino Ferreira, Cibele Masotti, Rodrigo Saddi, Karina Perez Sacardo, Felipe Sales Nogueira Amorim Canedo, Leandro Jonata Carvalho Oliveira, Daniele Coelho Duarte, Paula Fontes Asprino, Ernande Xavier dos Santos, Elisângela Monteiro Coser, Dimitrios Kleftogiannis, Louise J. Barber, Marco Gerlinger, João Victor Machado Alessi, Andrea Kazumi Shimada, Fernando Costa Santini, Ciro Eduardo de Souza, Olavo Feher, Gilberto de Castro Junior, Frederico Perego Costa, Max Senna Mano, Artur Katz, Anamaria Aranha Camargo, Fabiana Bettoni   +26 more
wiley   +1 more source

Use of Metronomic Chemotherapy in Hormone Receptor‐Positive/HER2‐Negative Metastatic Breast Cancer: A Retrospective Multicenter Study

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Purpose The optimal chemotherapy strategy after progression on cyclin‐dependent kinase 4/6 inhibitors (CDK4/6i) in hormone receptor‐positive/human epidermal growth factor receptor 2‐negative (HR+/HER2−) metastatic breast cancer remains a matter of controversy.
Lara Laini, Deborah Cosentini, Marta Laganà, Salvatore Grisanti, Giulia Scartabellati, Gianluca Fogazzi, Salvatore Strazzeri, Vito Amoroso, Greta Schivardi, Rebecca Pedersini, Alfredo Berruti, Antonella Turla   +11 more
wiley   +1 more source

Everolimus in diffuse large B-cell lymphomas

, 2015
Satisfactory treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) is not currently available and novel therapies are needed. mTOR is an intracellular kinase that is part of an aberrantly activated pathway in DLBCL.
Arcaini, Luca, Merli, Michele, Ferrario, Andrea, Maffioli, Margherita, PASSAMONTI, FRANCESCO   +4 more
core   +1 more source

Combined treatment by octreotide and everolimus: Octreotide enhances inhibitory effect of everolimus in aggressive meningiomas.

, 2015
International audienceTreatment for recurrent and aggressive meningiomas remains an unmet medical need in neuro-oncology, and chemotherapy exhibits limited clinical activity, if any.
Mohamed, Amira, Lisbonis, Christophe, Chinot, Olivier, Roche, Pierre-Hugues, Metellus, Philippe, Defilles, Céline, Figarella-Branger, Dominique, Adetchessi, Tarek, Fuentes, Stéphane, Barlier, Anne, A., Enjalbert, Alain, Graillon, Thomas, Germanetti, Anne-Laure, Dufour, Henry   +13 more
core   +1 more source

Progression‐free survival and objective response rate as a surrogate end point for overall survival in metastatic renal cell carcinoma: A systematic review and meta‐analysis

Cancer, Volume 132, Issue 19, 1 October 2026.
ABSTRACT The objective of this systematic review and meta‐analysis was to evaluate the validity of progression‐free survival (PFS) and the objective response rate (ORR) as surrogate end points for overall survival (OS) in randomized controlled trials (RCTs) of metastatic renal cell carcinoma.
Russell Leong, David Chen, Laith Almasri, Nicholas Lum, Karren Xiao, Maryam Soleimani, Christian K. Kollmannsberger, Srinivas Raman   +7 more
wiley   +1 more source

Everolimus for the treatment of refractory seizures associated with tuberous sclerosis complex (TSC): current perspectives

, 2019
Iris E Overwater,1 André B Rietman,2 Agnies M van Eeghen,3 Marie Claire Y de Wit11Department of Pediatric Neurology and ENCORE Expertise Center, Erasmus MC, Rotterdam, the Netherlands; 2Department of Child and Adolescent Psychiatry/Psychology and ...
Overwater IE, de Wit MCY, Rietman AB, van Eeghen AM   +3 more
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