Results 131 to 140 of about 45,933 (222)

Apoptosis and treatment of chronic allograft nephropathy with everolimus.

, 2003
BACKGROUND: Chronic allograft nephropathy (CAN) is responsible for most cases of late kidney allograft loss. However, no effective treatment is available so far.
Lutz, J;Zou, H;Liu, S;Antus, B;Heemann, U
core   +1 more source

Myelodysplastic Syndromes‐Transformed Acute Myeloid Leukemia With Concurrent DEK::CAN Fusion Gene Positivity and WT1 Overexpression: A Case Report and Literature Review

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders with a risk of progression to acute myeloid leukemia (AML). MDS‐transformed AML (MDS‐AML) has a poor prognosis. The concurrent presence of DEK::CAN fusion gene positivity and WT1 overexpression is extremely rare and likely denotes a highly ...
Wanxiu Mao, Tengmin Zhou, Xi Xu, Sheng Luo, Songfu Jiang, Zhijie Yu   +5 more
wiley   +1 more source

Radiation-Induced Esophagitis Exacerbated by Everolimus

, 2013
Background: Everolimus, a potent mammalian target of rapamycin (mTOR) inhibitor, has shown anticancer activity against various types of cancer, including renal cell carcinoma (RCC); however, little information is available on the efficacy and safety of ...
Yuji Miura, Jimpei Miyakawa, Koichi Suyama, Hiroki Kobayashi, Akiyoshi Uki, Toshikazu Okaneya, Akihiko Shimomura, Toshimi Takano   +7 more
core   +1 more source

Mitochondrial Metabolic Reprogramming in Glioma: Mechanisms of Tumorigenesis and Implications for Clinical Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In gliomas, mitochondria integrate glucose, lipid, protein, and nucleotide metabolism to support proliferation, invasion, treatment resistance, and adaptation, with D‐2‐hydroxyglutarate‐driven remodeling in IDH‐mutant tumors and diverse metabolic states in IDH wild‐type glioblastomas.
Liangqi Jiang, Mingrui Li, Zhen Li, Qing Liu, Yang Li   +4 more
wiley   +1 more source

Integrative characterization of human hepatocellular carcinoma‐derived organoids and their HBV‐associated biology

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
20 HCC‐derived organoids, three adjacent non‐tumour tissue‐derived organoids, and 12 HCC‐derived cell lines from 20 patients were established and biobanked. Integrative analyses combining drug screening, whole‐exome sequencing, and RNA sequencing revealed molecular subtypes and identified candidate determinants of lenvatinib response.
Seo‐Hyeon Kim, YoungRok Choi, Eun Woo Choi, Se Hui Kim, Seung Cheol Oh, Jae Yoon Kim, Su young Hong, Suk Kyun Hong, Kwang‐Woong Lee, Ja‐Lok Ku   +9 more
wiley   +1 more source

Everolimus triggers cytokine release by macrophages : rationale for stents eluting everolimus and a glucocorticoid

, 2012
: Objective-: Stent-based delivery of the mammalian target of rapamycin (mTOR) inhibitor everolimus is a promising strategy for the treatment of coronary artery disease. We studied potential adverse effects associated with mTOR inhibition.
Martinet, Wim, van Brussel, Ilse, Timmermans, Jean-Pierre, Verheye, Stefan, De Meyer, Inge, Bult, Hidde, De Meyer, Guido, Schrijvers, Dorien M.   +7 more
core  

Hyperglycaemia during treatment with everolimus

, 2014
BACKGROUND: Everolimus is an orally administered anti-cancer drug that inhibits the mammalian target of rapamycin (mTOR) signal transduction route. Use of everolimus may be associated with insulin resistance, manifesting in impaired glucose tolerance or ...
Schellens, Jan H M, Huitema, Alwin D R, Opdam, Frans L, Beijnen, Jos H   +3 more
core  

Targeting the PI3K/Akt Signaling Pathway: A Promising Therapeutic Strategy to Reduce Cancer Mortality and Overcome Chemoresistance

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims The phosphatidylinositol 3‐kinase (PI3K)/Akt signaling pathway is a central regulator of cellular properties that are essential for cancer progression, including cellular growth, survival, metabolism, and angiogenesis. Dysregulated PI3K/Akt signaling, often caused by genetic alterations in PIK3CA, loss of PTEN, or the ...
Md Mohiuddin
wiley   +1 more source

Open-label Phase II study of everolimus plus endocrine therapy in postmenopausal women with ER-positive and HER2-negative metastatic breast cancer (Chloe trial)

, 2018
Tatsunori Shimoi,1 Akihiko Shimomura,1 Tadahiko Shien,2 Yukari Uemura,3 Hiroaki Kato,4 Masahiro Kitada,5 Tatsuya Toyama,6 Tomohiko Aihara,7 Hirofumi Mukai8 1Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan ...
Kato H, Toyama T, Shien T, Shimomura A, Aihara T, Kitada M, Mukai H, Shimoi T, Uemura Y   +8 more
core  

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source