Results 31 to 40 of about 280,308 (219)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Open government data and environmental science: a federal Canadian perspective
FACETS, 2020 Governments worldwide are releasing data into the public domain via open government data initiatives. Many such data sets are directly relevant to environmental science and complement data collected by academic researchers to address complex and ...
Dominique G. Roche +7 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Response to “Every ROSE has its thorns”
Environmental Evidence, 2018 Sharp et al. [1] raise a number of concerns about the development and communication of ROSES (RepOrting standards for Systematic Evidence Syntheses), and we welcome the opportunity to explain some of the underlying thinking behind development of the ...
Neal R. Haddaway +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Ecological Solutions and EvidenceInvasive freshwater aquatic plants can have adverse ecological effects on the systems to which they are introduced, changing ecosystem function, threatening native plant species and causing billions of dollars in damage to infrastructure.
Meagan Harper +3 more
doaj +1 more source
Environmental Evidence, 2019 Background The incorporation of multiple types of knowledge (e.g., science, Indigenous knowledge, traditional ecological knowledge) is an important undertaking, which can strengthen the evidence-base for policy advice, decision making, and environmental ...
Steven M. Alexander +4 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Ecological Solutions and Evidence, 2021 Human activities and development have contributed to declines in biodiversity across the globe. Understanding and addressing biodiversity loss will require the mobilization of diverse knowledge systems.
Dominique A. Henri +11 more
doaj +1 more source